Fungal endophytes associated with mangroves – Chemistry and biopharmaceutical potential

Bibi, Sadeer Nabeelah; Zengin, Gökhan; Jeewon, Rajesh; Mahomoodally, Mohamad Fawzi

doi:10.1016/j.sajb.2019.12.016

Cited by 28 publications

(23 citation statements)

References 102 publications

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“…These compounds have been proved to have the biological activities previously shown, including antimicrobial, antiviral, larvicidal, antimalarial, anti-tumor and antidiabetic (Strobel and Daisy, 2003;Golinska et al, 2015;Matsumoto and Takahashi, 2017). Therefore, isolation of endophytes from medicinal plants may provide new opportunities to discover diverse species and natural products using for medicine, agriculture, and industry (Aly et al, 2011;Ding et al, 2013;Golinska et al, 2015;Jeewon et al, 2019;Bibi et al, 2020).…”

Section: Introductionmentioning

confidence: 98%

Diversity and Bioactivity of Endophytes From Angelica sinensis in China

et al. 2020

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Plant seeds are not merely reproductive organs, they are also carriers of microorganism, particularly, inherent and non-invasive characteristic endophytes in host plant. Therefore, in this study, the endophytic diversity of Angelica seeds was studied and compared with endophytes isolated from healthy leaves, stems, roots, and seeds of A. sinensis using 20 different media. The metabolites of endophytic strains were evaluated with six different methods for their antioxidant activity and the paper disc diffusion method for antimicrobial activities. As a result, 226 endophytes were isolated. Compared with the biodiversity and abundance of uncultured fungi from Angelica seed, the result showed that the most frequent endophytic fungi were Alternaria sp. as seen in artificial media; moreover, compared with artificial media, the pathogenic fungi, including Fusarium sp. and Pseudallescheria sp., were not found from the Angelica seed, the results suggested it may not be inherent endophytes in plants. In addition, bacteria from seven phyla were identified by high-throughput sequencing, while five phyla of endophytic bacteria were not isolated on artificial media including Proteobacteria, Actinobacteria, Bacteroidetes, Microgenomates, and Saccharibacteria. Furthermore, the sample JH-4 mycelium displayed the best antioxidant activity, and the active constituent may be a flavonoid as determined by total phenol and flavonoid content. Moreover, YH-12-1 mycelium had strong inhibitory activity against the five tested strains and the minimum inhibitory concentration (MIC) against Pseudomonas aeruginosa and Streptococcus pneumoniae was found to be 25 µg/mL. Our results confirm that plant endophytes are rich in biodiversity and contain important resource of many uncultured microorganisms.

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Section: Introductionmentioning

confidence: 98%

Diversity and Bioactivity of Endophytes From Angelica sinensis in China

et al. 2020

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“…This concentration may be triggered by unpredictable marine environmental nature. Recently, the closed result was reported by Tang et al ( Tang et al, 2008 ); Bibi et al ( Bibi et al, 2020 ), and the marine mangrove actinomycetes has excellent anti-bacterial activity against multi drug resistant bacteria. Previously, Sudha et al ( Sudha and Masilamani, 2012 ) reported that the marine mangrove region mediated actinomycetes is an excellent antibiotic producer due to the unpredictable environmental parameters.…”

Section: Resultsmentioning

confidence: 88%

Partially purified actinomycetes compounds enhance the intracellular damages in multi-drug resistant P. aeruginosa and K. pneumoniae

Kadaikunnan

Alharbi

Khaled

et al. 2021

Saudi Journal of Biological Sciences

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Based on the excellent nutrient level, the current study was focused on isolation and anti-bacterial activity of the actinomycetes from marine mangrove soil samples. As result, 10 different strains of actinomycetes strains were identified on actinomycetes isolation agar plates. The identified strains were shown with white, clear, uncontaminated well matured spore producing ability. Based on the initial observation, the isolated colonies were actinomycetes . The partially extracted crude compound shown excellent anti-bacterial activity against P. aeruginosa and K. pneumoniae with 15 mm and 13 mm zone of inhibitions were observed at 500 μL concentrations. The minimum inhibition concentration result was also confirmed the 500 μL concentration against both the tested concentration with high inhibition rate. Then, the intracellular damages, decreased cell growth of the crude actinomycetes extract treated bacterial strains were clearly observed by confocal laser scanning electron microscope. The extracellular damages of bacterial cell wall and shape of the both the pathogens were clearly shown by scanning electron microscope. Therefore, all the results were clearly supported to the partially extracted crude compound and it has excellent anti-bacterial activity against tested multi drug resistant bacteria.

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“…Fungal endophytes have already been reported in Avicennia alba (Lee et al, 2019) and in A. marina (Bhimba et al, 2012;Basheer et al, 2018;Bibi et al, 2020). Penicillium citrinum was reported in the latter (Liu J. et al, 2015).…”

Section: Discussionmentioning

confidence: 90%

“…These metabolites have found many applications in agriculture and in the discovery of new drugs and include compounds with some antimicrobial activity (Schulz et al, 2002;Strobel, 2003;Schueffler and Anke, 2014). More specifically, fungal endophytes isolated from mangrove plants have displayed anticancer, antimicrobial, antiviral, antitubercular, anti-inflammatory, anti-oxidant, antidiabetic, antiparasitic, antihypertensive and immunomodulatory activity (Tejesvi et al, 2008;Proksch et al, 2010;Kaul et al, 2012;Salini, 2015;Bibi et al, 2020). Examples of biologically active metabolites produced by fungal endophytes include pestalotiopsones A-F, talaperoxides A-D, steperoxide B (Li et al, 2011), xylacinic acids A-B, cytochalasin D, isosclerone (Klaiklay et al, 2012), nectriacids A-C and 12-epicitreoisocoumarinol (Cui et al, 2016).…”

Section: Introductionmentioning

confidence: 99%