Fungal contamination in barley and Kashin-Beck disease in Tibet

Chasseur, Camille; Suetens, Carl; Nolard, N.; Begaux, Françoise; Haubruge, Éric

doi:10.1016/s0140-6736(05)70453-0

Cited by 59 publications

(56 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variety of hypotheses (Fang 1988;Zamana 1995;Chasseur et al 1997;La et al 2001;Chasseur et al 2001;Suetens et al 2001) have been proposed since 1849 when the disease was first discovered in Russia. Selenium deficiency in the environment, organic matter in drinking water, and fungal contamination in stored grains or food are three dominating opinions on the etiology of KBD (Tan et al 1988).…”

Section: Introductionmentioning

confidence: 99%

Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau, China

Zhang

Yang

Wang

et al. 2010

Environ Geochem Health

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau, China

Zhang

Yang

Wang

et al. 2010

Environ Geochem Health

View full text Add to dashboard Cite

“…Previous epidemiological investigations in endemic KBD areas on the Tibetan plateau have revealed agroenvironmental conditions favourable to the severe infection of barley grains by fungi belonging to the Drechsera, Trichotecium and Alternaria genera [4]. In Tibet, both its high altitude and the extremely severe weather conditions affect the availability of natural resources and the use of land [7].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of mycotoxins in Kashin-Beck disease

Haubruge

Chasseur²,

Debouck³

et al. 2001

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

Mycotoxins are naturally occurring toxic chemical compounds produced by fungi infesting agricultural crops both during their growth and storage. Such secondary metabolites, when ingested, can produce toxic syndromes in humans. As it has been suggested that mycotoxins might be involved in the development of Kashin-Beck disease (KBD), we undertook a survey of barley grains of KBD-affected families and non-affected families in that country. We found, by thin layer chromatography, a hitherto unknown metabolite of Alternaria sp. This was especially common on the barley grains of KBD-affected families.Résumé Les mycotoxines sont des métabolites secondaires produits des champignons infestant les céréales au cours de la période culturale ou durant le stockage des grains. De telles substances chimiques peuvent être toxiques vis-à-vis de l'homme lorsqu'elle sont ingérées. La contamination des grains de céréales par des mycotoxines constitue toutefois une piste sérieuse pour la compré-hension de l'étiologie de la maladie de Kashin-Beck.Nous avons entrepris des analyses de plusieurs mycotoxines sur des échantillons de grains d'orge provenant de familles malades et de familles non malades au Tibet. Un métabolite, encore inconnu, produit par Alternaria spp. a été détecté dans les échantillons de grains provenant des familles malades.

show abstract

“…Even if, for methodological reasons, it is impossible to compare clinical data from Tibet [10] with those from Yulin in China, it seems that the lesions in KBD patients living in Yulin are less severe than in Tibetans. Fungi present in cereals exposed to humidity for long periods have also been implicated in the pathogenesis of KBD [2]. Mycotoxins were not specifically measured, but it is known that grain humidity and the presence of fungal contamination in grain are directly associated with the presence of mycotoxins [6].…”

Section: Discussionmentioning

confidence: 99%

“…Two-hundred and fifty gram cereal samples (barley) were collected from each family and stored in paper bags at 0-4°C while awaiting mycological examination. The humidity of the grain was determined on whole grains as in the Tibet study [2]. Their water content is the value obtained after grinding the grain [19].…”

Section: Methodsmentioning

confidence: 99%

Selenium, iodine and fungal contamination in Yulin District (People's Republic of China) endemic for Kashin-Beck disease

Zhang

Nève²,

et al. 2001

International Orthopaedics (SICOT)

View full text Add to dashboard Cite

We studied the status of selenium, iodine and fungal contamination in 353 school children (age 5-14 years) from four rural villages in the District of Yulin. In three villages Kashin-Beck disease (KBD) was endemic, whereas there were no cases of KBD in the fourth village. Clinical, biological and radiological examinations (right hand) were performed and KBD was established by X-ray diagnosis. The prevalence rate of KBD was 30.2%, 44.2% and 45.3% in the three endemic villages. Mean hair selenium and urine iodine concentrations were lower in affected than in unaffected children and fungal contamination in cereal grains stored in families with KBD was more elevated than in families without KBD. Low hair selenium concentration and presence of fungal cereal contamination were significantly associated with an increased risk of KBD, but low urine iodine was not.Résumé Nous avons étudié les statuts en sélénium, en iode et la contamination fongique auprès de 353 écoliers âgés de 5 à 14 ans habitant dans quatre villages ruraux dans le district de Yulin. Dans trois villages la maladie de KB ètait endemique et dans un village contrôle aucun enfant ne présentait la maladie. Des examens cliniques, biologiques et radiologiques ont été réalisés et le KBD a été diagnostiqué par examen radiologique. La prévalence de l'atteinte était de 30.2%, 44.2% et 45.3% dans les trois villages endémiques. La teneur moyenne en sélé-nium des cheveux et la concentration moyenne en iode urinaire étaient plus basses chez les enfants atteints que chez les contrôles et la contamination fongique des cé-réales était plus élevée au sein des familles avec la maladie qu'au sein des familles sans maladie. L'analyse statistique montre qu'une teneur basse en sélénium dans les cheveux et une contamination fongique des céréales sont des facteurs significativement associés à un risque accru de maladie, mais pas une concentration basse en iode urinaire.

show abstract

Fungal contamination in barley and Kashin-Beck disease in Tibet

Cited by 59 publications

References 2 publications

Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau, China

Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau, China

The prevalence of mycotoxins in Kashin-Beck disease

Selenium, iodine and fungal contamination in Yulin District (People's Republic of China) endemic for Kashin-Beck disease

Contact Info

Product

Resources

About