Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau, China

Zhang, Baojun; Yang, Linsheng; Wang, Wuyi; Li, Yonghua; Li, Hairong

doi:10.1007/s10653-010-9366-y

Cited by 59 publications

(24 citation statements)

References 16 publications

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“…The incidence rates in children aged 4-12 years, detected by radiography, were 59 children (50.4 %) of 117 children in Sangri [21], 20 children (33.9 %) out of 59 children in Linzhou [21], and 200 out of 331 children in Changdu, in proportion of 60.4 % [22]. Se deficiency was also associated with the KBD prevalence and severity in Tibet, which was observed by previous studies [20,23,24].…”

Section: Introductionsupporting

confidence: 53%

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Hair Selenium Levels of School Children in Kashin–Beck Disease Endemic Areas in Tibet, China

Chen

Yang

et al. 2015

Biol Trace Elem Res

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Previous studies have shown that the selenium (Se) deficiency is an important factor for the etiology of KashinBeck disease (KBD). Although KBD is presently controlled in most regions of China, it is still active in the Tibetan Plateau. The present study aimed to assess the nutritional status of selenium in school children by using the Se level in hair as a biomarker in KBD endemic areas of Lhasa in Tibet, China. Hair samples of 155 school children aged 6-15 years were collected in both KBD areas and non-KBD areas of Lhasa in 2013. The Se level in the hair samples was determined by inductive coupled plasma mass spectrometry (ICP-MS). The average concentration of Se in children's hair was 0.232 μg/g in KBD areas of Lhasa, which was significantly higher than the data reported decades ago. A significant difference in hair Se was observed between the boys (0.255 μg/g) and the girls (0.222 μg/g) in the studied KBD areas (P<0

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Section: Introductionsupporting

confidence: 53%

“…The hair samples were washed three times with neutral detergent, rinsed with distilled water, and dried in an oven at a temperature of 60°C for 6-8 h. Then, the hair samples were cut into small pieces (2-3 mm) for Se determination [24,40].…”

Section: Sample Collection and Preparationmentioning

confidence: 99%

Hair Selenium Levels of School Children in Kashin–Beck Disease Endemic Areas in Tibet, China

Chen

Yang

et al. 2015

Biol Trace Elem Res

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“…Traditionally, Tibetan peoples drink tea or homemade beer ( chang ) but little water. Until recently, the main sources of water for the population used to be well water or surface water [28], with all the risks related to chemical, microbial, and biological contaminants. During the study, only 5% and 12% of the children consumed river water (used in the preparation of tea drinks or soup) in September 2012 and April 2013, respectively.…”

Section: Resultsmentioning

confidence: 99%

Minerals and Trace Elements Intakes and Food Consumption Patterns of Young Children Living in Rural Areas of Tibet Autonomous Region, P.R. China: A Cross-Sectional Survey

Dermience

Mathieu²,

et al. 2017

Healthcare

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Background and objectives: Several studies revealed clinical signs of stunting and rickets among rural populations of Tibet Autonomous Region (T.A.R.), and especially amid children. Further, these populations are affected by a bone disease named Kashin-Beck disease (KBD). However, little is known about the dietary status of this population. This survey aimed to assess the usual intakes of young Tibetan children living in rural areas around Lhasa for energy, water, and ten minerals and trace elements (Na, K, Ca, P, Mg, Fe, Zn, Cu, Mn, and Se) involved in bone metabolism. Design: A cross-sectional survey was designed. Totally, 250 pre-school children aged 3–5 years living in rural areas were enrolled. The 24-h food recall method was used to collect the intakes for two days, during two different seasons (September 2012 and April 2013). Because Tibetan foods are mainly derived from local agriculture and artisanal production, a combination of food composition tables was compiled, including specific and local food composition data. Results: The Chinese dietary recommended intakes are not met for most of the elements investigated. Intake of sodium is much too high, while usual intakes are too low for K, Ca, Zn, Cu, and Se. Bioavailability of Ca, Fe, and Zn may be of concern due to the high phytic acid content in the diet. Conclusion: These nutrient imbalances may impact growth and bone metabolism of young Tibetan children. The advantages of the implementation of food diversification programs are discussed as well as the relevance of supplements distribution.

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“…If TSH was >6.25 m U/L, then only FT4 was measured. Serum selenium was determined by hydride generation atomic fluorescence spectrometry (HG-AFS) using a method described elsewhere [11]. Serum was digested in a mixture of concentrated HNO3 and HC1O 4 (V: V = 4:1) first and then determined by HG-AFS.…”

Section: Methodsmentioning

confidence: 99%

Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study

et al. 2013

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BackgroundSelenium (Se) is a necessary element for the biosynthesis of thyroid hormones. We investigated the relationship between selenium status, thyroid volume, and goiter in a cross-sectional study in an iodine-sufficient area.MethodsWe selected residents of Chengdu (over 18 years old and living in the city for more than 5 years) using a stratified cluster sampling technique. Fifteen hundred subjects were selected for the study, which involved a questionnaire survey, physical examination, thyroid ultrasound, serum thyroid function test, and determination of serum selenium level. Thyroid volume was calculated from the thickness, width, length, and a corrective factor for each lobe. Ultimately, 1,205 subjects completed the investigation and were included in our study. Additionally, 80 school-age children were selected to provide urine samples for urinary iodine analysis. We analyzed the data using appropriate nonparametric and parametric statistical tests.ResultsThe median urinary iodine value was 184 μg/L in school-age children, indicating iodine sufficiency. The median serum selenium level of the 1,205 subjects was 52.63 (interquartile range [IQR] : 40.40-67.00) μg/L. The median thyroid volume was 9.93 (IQR: 7.71-12.57) mL; both log-transformed serum selenium and log-transformed thyroid volume were Gaussian distributions (P = .638 and P = .046, respectively). The prevalences of goiter and thyroid nodules were 8.8% and 18.6%. The prevalences of positive thyroid autoantibodies, thyroperoxidase autoantibodies and thyroglobulin autoantibodies were 16.7%, 12.0%, and 11.1%, respectively. In the general linear regression model, there were positive associations between serum selenium and age, and body mass index. We found no association between serum selenium and thyroid-stimulating hormone. In simple linear regression analyses, we found no association between thyroid volume and serum selenium. There were no significant differences in serum selenium between persons with or without goiter. Serum selenium was not a risk factor for goiter.ConclusionIn our study population, serum selenium was neither associated with thyroid volume nor with goiter in an iodine-sufficient area. More studies should be conducted by following non-goitrous persons over time and monitoring their selenium status.

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Environmental selenium in the Kaschin–Beck disease area, Tibetan Plateau, China

Cited by 59 publications

References 16 publications

Hair Selenium Levels of School Children in Kashin–Beck Disease Endemic Areas in Tibet, China

Hair Selenium Levels of School Children in Kashin–Beck Disease Endemic Areas in Tibet, China

Minerals and Trace Elements Intakes and Food Consumption Patterns of Young Children Living in Rural Areas of Tibet Autonomous Region, P.R. China: A Cross-Sectional Survey

Thyroid volume, goiter prevalence, and selenium levels in an iodine-sufficient area: a cross-sectional study

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