Fungal beta-glucans as adjuvants for treating cancer patients – A systematic review of clinical trials

Steimbach, Laiza Maria; Borgmann, Ariela Victória; Gomar, Gabriella Giandotti; Hoffmann, Lucas Ventura; Rutckeviski, Renata; Andrade, Diancarlos Pereira de; Smiderle, Fhernanda Ribeiro

doi:10.1016/j.clnu.2020.11.029

Cited by 36 publications

(27 citation statements)

References 27 publications

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“…β-Glucan research is now focused on human studies: clinical trials and epidemiological assessment of the efficacy and safety of mushroom-derived β-glucans for cancer treatment and prevention [ 128 ]. Fungal β-glucans can be used as adjuvants for treating cancer patients [ 129 , 130 ]. In general, β-glucans are a promising option for cancer prevention and treatment, especially for cervical cancer.…”

Section: The Antitumor Effect Of β-Glucan In Humansmentioning

confidence: 99%

“…It was concluded that most of the tested β-glucans stimulated phagocytosis and IL-2 secretion, reduced cancer growth, and ameliorated the effects of the experimental infections. Some clinical trials of fungal β-glucans as an adjuvant therapy for cancer started to appear in the literature in the 1980s [ 130 ].…”

Section: The Antitumor Effect Of β-Glucan In Humansmentioning

confidence: 99%

“…A comprehensive review of mushroom β-glucans in cancer therapy suggested stimulation of immune system as the basic mechanism of action [ 128 ]. Fungal β-glucans are promising as an adjuvant therapy for cancer [ 130 ], as well as modulating the immune system weakened by radiotherapy and chemotherapy in cancer treatment [ 32 ].…”

Section: The Antitumor Effect Of β-Glucan In Humansmentioning

confidence: 99%

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Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

Větvička

Teplyakova

Shintyapina

et al. 2021

JoF

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Section: The Antitumor Effect Of β-Glucan In Humansmentioning

confidence: 99%

Section: The Antitumor Effect Of β-Glucan In Humansmentioning

confidence: 99%

Section: The Antitumor Effect Of β-Glucan In Humansmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

Větvička

Teplyakova

Shintyapina

et al. 2021

JoF

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“…They exist most commonly as cellulose in plants, the cell walls of yeast, and as certain fungi and mushrooms [26]. β-glucans derived from either yeast or mushrooms were reported to enhance immunity against tumors or viruses [27].…”

Section: Wbm Suppresses Dht-induced Ar-tmprss2 Expression In Putative Covid-19 Impacted Organs In Micementioning

confidence: 99%

White Button Mushroom (Agaricus bisporus) Interrupts Tissue AR-TMPRSS2 Expression and Attenuates Pro-inflammatory Cytokines in C57BL/6 Mice: Implication for COVID-19 Dietary Intervention

Chen

Wang

et al. 2021

Preprint

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Transmembrane protease serine 2 (TMPRSS2), an androgen-induced protease associated with prostate cancer, is one putative receptor for coronavirus entry into host cells, where triggering aggressive inflammatory cytokine storm and possibly death in COVID-19 patients. We previously reported that dietary white button mushroom (WBM) antagonized dihydrotestosterone (DHT)-induced androgen receptor (AR) activation and reduced myeloid-derived suppressor cells (MDSCs) in prostate cancer animal models and patients. The present study on C57BL/6 mice revealed that WBM is a unique food that A) interrupts DHT induced AR-TMPRSS2 expression in putative COVID-19 targeted organs through its AR antagonistic activity and B) attenuates serum pro-inflammatory cytokines which have been implicated in COVID-19 pathogenesis. We hereby propose WBM intake as a potentially low-cost, efficient, and safe dietary intervention to mitigate COVID-19.

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“…Beta-glucan are obtained from diverse sources such as plants, cereals, algae, bacteria, and fungal entities, producing highly divergent biological effects owing to disparity in physicochemical properties; namely, tertiary configuration, solubility, length of polymer, molecular weight, and degree of branching [ 13 , 14 ]. At present, a growing list of beta-glucan preparations has been a subject of human clinical trials [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models

Desamero

Chung

Kakuta

2021

IJMS

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Understanding the host anti-fungal immunity induced by beta-glucan has been one of the most challenging conundrums in the field of biomedical research. During the last couple of decades, insights on the role of beta-glucan in fungal disease progression, susceptibility, and resistance have been greatly augmented through the utility of various beta-glucan cognate receptor-deficient mouse models. Analysis of dectin-1 knockout mice has clarified the downstream signaling pathways and adaptive effector responses triggered by beta-glucan in anti-fungal immunity. On the other hand, assessment of CR3-deficient mice has elucidated the compelling action of beta-glucans in neutrophil-mediated fungal clearance, and the investigation of EphA2-deficient mice has highlighted its novel involvement in host sensing and defense to oral mucosal fungal infection. Based on these accounts, this review focuses on the recent discoveries made by these gene-targeted mice in beta-glucan research with particular emphasis on the multifaceted aspects of fungal immunity.

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Fungal beta-glucans as adjuvants for treating cancer patients – A systematic review of clinical trials

Cited by 36 publications

References 27 publications

Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

White Button Mushroom (Agaricus bisporus) Interrupts Tissue AR-TMPRSS2 Expression and Attenuates Pro-inflammatory Cytokines in C57BL/6 Mice: Implication for COVID-19 Dietary Intervention

Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models

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