Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

Větvička, Václav; Teplyakova, T. V.; Shintyapina, Alexandra; Короленко, Т А

doi:10.3390/jof7040250

Cited by 41 publications

(32 citation statements)

References 132 publications

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“…The adjuvant mechanism of immune system activation depends on the formation of an immune complex of β-glucans, after recognition as PAMP, with anti-β-glucan antibodies, which through immune effector cells and C3 phagocytes facilitates killing of tumor cells, as represented in Figure 2 [37]. The major roles of mushroom-derived β-glucans on cancer progression have been extensively reviewed [38]. A promising application of β-glucans is their use in cancer treatment, as adjuvant of conventional therapies.…”

Section: β-Glucans As Adjuvants In Oncological Disordersmentioning

confidence: 99%

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Edible Mushrooms and Beta-Glucans: Impact on Human Health

2021

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Mushroom cell walls are rich in β-glucans, long or short-chain polymers of glucose subunits with β-1,3 and β-1,6 linkages, that are responsible for the linear and branching structures, respectively. β-glucans from cereals, at variance, have no 1,6 linkages nor branching structures. Both immunomodulatory and anti-inflammatory effects of mushrooms have been described using purified β-glucans or fungi extracts on cellular and experimental models; their potential clinical use has been tested in different conditions, such as recurrent infections of the respiratory tract or complications of major surgery. Another promising application of β-glucans is on cancer, as adjuvant of conventional chemotherapy. β-glucans may protect the cardiovascular system, ameliorating glucose, lipid metabolism, and blood pressure: these activities, observed for oat and barley β-glucans, require confirmation in human studies with mushroom β-glucans. On the other hand, mushrooms may also protect the cardiovascular system via a number of other components, such as bioactive phenolic compounds, vitamins, and mineral elements. The growing knowledge on the mechanism(s) and health benefits of mushrooms is encouraging the development of a potential clinical use of β-glucans, and also to further document their role in preserving health and prevent disease in the context of healthy lifestyles.

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Section: β-Glucans As Adjuvants In Oncological Disordersmentioning

confidence: 99%

“…The major roles of mushroom-derived β-glucans on cancer progression have been extensively reviewed [ 38 ]. A promising application of β-glucans is their use in cancer treatment, as adjuvant of conventional therapies.…”

Section: β-Glucans Biological Effectsmentioning

confidence: 99%

Edible Mushrooms and Beta-Glucans: Impact on Human Health

2021

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“…Bioactive compounds, such as -glucans, were found in these L. rhinocerus MB-EPS extracts; use of glucans have gained appeal in recent years for a number of emerging applications including biopolymers 30 and biomedicines 31 . It is notable that mushroom-derived -glucans have many new therapeutic properties, including (a) potential new or complementary immunotherapies against Coronavirus disease (SARS-CoV-2) 14 , (b) potential new therapeutic agent for mitigating diseases associated with gastrointestinal mucosal damage, such as peptic ulcers and inflammatory bowel disease 32 , (c) potential as anticancer drugs for lung and breast cancer 33 , and (d) potentially asthmatic treatment 23,34 . However, there is a marked gap in knowledge surrounding the toxicity (if any), of these mushroom-derived bioactive compounds; particularly use of Zebrafish trials that would aid product development and implementation.…”

Section: Discussionmentioning

confidence: 99%

In-Vivo Toxicity of Bioreactor-Grown Biomass And Exopolysaccharides From Malaysian Tiger Milk Mushroom Mycelium For Potential Future Health Applications

Usuldin

Wan-Mohtar

Ilham

et al. 2021

Preprint

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Natural mycelial biomass (MB) and exopolysaccharide (EPS) produced from bioreactor-grown Malaysian Tiger Milk Mushroom Lignosus rhinocerus are considered high-end components due to their high commercial potential value in drug discovery. Both MB (0.16-10 mg/mL) and EPS (0.16-10 mg/mL) extracts were tested for Zebrafish Embryo Toxicity (ZFET) and early development effects on Zebrafish Embryos (ZE) during 24-120 h post-fertilization (HPF) in order to assess toxicity given potential application as a new therapy for treating asthma. Finding revealed that MB was deemed to be safe with an LC50 of 0.77 mg/mL; EPS was shown to be non-toxic (LC50 of 0.41 mg/mL). Neither MB nor EPS delayed hatching nor teratogenic defects in treated ZE at a dose of 2.5 mg/mL. There were no significant changes in the ZE heart rate after MB or EPS treatments with MB (0.16-10 mg/mL: 130 beats/min) and EPS (0.16-10 mg/mL: 140 beats/min), as compared to normal ZE (120-180 beats/min). In addition, mixing of both natural compounds MB and EPS did not affect toxicity using ZFET testing; thus, intimating their safe future use as therapeutic interventions.

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“…β−glucans linked with chitin chains ensure the simultaneous rigidity and flexibility of the fungal cell wall. These compounds most often have the structure of β-D-glucans or β-mannans [ 100 , 101 ]. Their activity is determined by their molecular weight, solubility in water, number of branches and tertiary structure.…”

Section: Bioactive Compounds Of Fungi and Their Health-promoting Propertiesmentioning

confidence: 99%

Fungi and Algae as Sources of Medicinal and Other Biologically Active Compounds: A Review

2021

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Many species of fungi including lichenized fungi (lichens) and algae have the ability to biosynthesize biologically active compounds. They produce, among others, polysaccharides with anticancer and immunostimulatory properties: (1) Background: This paper presents the characteristics of the most important bioactive compounds produced by fungi and algae; (2) Methods: Based on the example of the selected species of mushrooms, lichens and algae, the therapeutic properties of the secondary metabolites that they produce and the possibilities of their use are presented; (3) Results: The importance of fungi, especially large-fruited mushrooms, lichens and algae, in nature and human life is discussed, in particular, with regard to their use in the pharmaceutical industry and their nutritional value; (4) Conclusions: The natural organisms, such as fungi, lichenized fungi and algae, could be used as supplementary medicine, in the form of pharmaceutical preparations and food sources. Further advanced studies are required on the pharmacological properties and bioactive compounds of these organisms.

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Effects of Medicinal Fungi-Derived β-Glucan on Tumor Progression

Cited by 41 publications

References 132 publications

Edible Mushrooms and Beta-Glucans: Impact on Human Health

Edible Mushrooms and Beta-Glucans: Impact on Human Health

In-Vivo Toxicity of Bioreactor-Grown Biomass And Exopolysaccharides From Malaysian Tiger Milk Mushroom Mycelium For Potential Future Health Applications

Fungi and Algae as Sources of Medicinal and Other Biologically Active Compounds: A Review

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