White Button Mushroom (Agaricus bisporus) Interrupts Tissue AR-TMPRSS2 Expression and Attenuates Pro-inflammatory Cytokines in C57BL/6 Mice: Implication for COVID-19 Dietary Intervention

Chen, Shiuan; Wang, Xiaoqiang; Ha, Desiree; Yoshitake, Ryohei

doi:10.21203/rs.3.rs-244245/v1

Cited by 3 publications

(2 citation statements)

References 51 publications

(61 reference statements)

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“…This suggests a promising perspective for counteracting the SARS-CoV-2 acute respiratory distress syndrome [156]. In another mice model with dihydrotestosterone-induced transmembrane protease serine 2 (AR-TMPRSS2) overexpression, which is a putative receptor for coronavirus entry into the host cells, the oral administration of a β-glucan-rich preparation from Agaricus bisporus (a white button mushroom) interrupted the expression of AR-TMPRSS2 in putative COVID-19-targeted organs and attenuated the serum pro-inflammatory cytokines, reminiscent of a cytokine storm [158]. Another promising compound for SARS-CoV-2 infection repression may be schizophyllan, a β-1-3-glucan extracted from the mushroom Schizophyllum commune that significantly diminishes the ACE2 and TMPRSS2 protein expression in vitro (on HEK 293T and HepG2 cell lines) and in vivo in mice without inducing cell damage [159].…”

Section: Randomized Clinical Trialsmentioning

confidence: 99%

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Lefter,

Balyan,

Balmus

et al. 2024

Microbiology Research

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Infection with the novel coronavirus SARS-CoV-2, the cause of coronavirus disease (COVID-19), has emerged as a global pandemic, with a high toll on casualties, economic impact, and human lifestyle. Despite the recent approval of various vaccines against the virus, challenges remain, including the limited availability of these vaccines, the prevalent rejection of vaccination by a large proportion of the population, and the recurrent appearance of new variants of the virus due to mutations. This context raises the alarm for scientists and clinicians to seek alternative and complementary therapies. In this context, natural products and their derivatives serve as reservoirs for potential therapeutic compounds that can be exploited in the research and production of antiviral drugs against COVID-19. Among these substances, lectin and polysaccharides isolated from fauna and flora emerge as complementary strategies for treating coronavirus infection. The review objective is to cover and analyze the specific role of polysaccharides and lectins and their synergy in the fight against this deadly SARS-CoV-2 virus. For this purpose, a primary literature search was conducted on Google Scholar, PubMed, and Web of Sciences using relevant keywords like “SARS-CoV-2 Variants”; “Antiviral Strategies”; “Antiviral Polysaccharides”; “Antiviral Lectins”; and “Synergistic effect”. The results demonstrate that lectins and polysaccharides exhibit antiviral activities against SARS-CoV-2 via mechanisms related to binding and steric blocking, the binding of glycan-based decoys, chemical reactions, virus particle disruption strategies, and steric blocking for competitive inhibition to block SARS-CoV-2 and its variants’ entry. In addition, this review analyzes the rationale behind combining polysaccharides and lectins, emphasizing complementary mechanisms of action. By simultaneously targeting multiple stages of the viral life cycle, this dual strategy aims to comprehensively inhibit viral propagation and enhance the durability of antiviral strategies over time.

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Section: Randomized Clinical Trialsmentioning

confidence: 99%

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Lefter,

Balyan,

Balmus

et al. 2024

Microbiology Research

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“…Agaricus bisporus (white button mushroom) extracts could terminate TMPRSS2 expression by anti-androgenic activity via conjugated linoleic acid and by initiating an anti-inflammatory reaction, possibly through β-glucans. Further, in vivo, pre-clinical toxicity studies on eight-week-old male intact C57BL mice at (The Jackson Laboratory, Sacramento, CA) showed no toxicity of Agaricus bisporus (white button mushroom) [ 80 , 81 ].…”

Section: Potential Of Natural Products Derived From Mushrooms For The...mentioning

confidence: 99%

Therapeutic Potential of Bioactive Compounds from Edible Mushrooms to Attenuate SARS-CoV-2 Infection and Some Complications of Coronavirus Disease (COVID-19)

Baruah,

Patra,

Barge

et al. 2023

JoF

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a highly infectious positive RNA virus, has spread from its epicenter to other countries with increased mortality and morbidity. Its expansion has hampered humankind’s social, economic, and health realms to a large extent. Globally, investigations are underway to understand the complex pathophysiology of coronavirus disease (COVID-19) induced by SARS-CoV-2. Though numerous therapeutic strategies have been introduced to combat COVID-19, none are fully proven or comprehensive, as several key issues and challenges remain unresolved. At present, natural products have gained significant momentum in treating metabolic disorders. Mushrooms have often proved to be the precursor of various therapeutic molecules or drug prototypes. The plentiful bioactive macromolecules in edible mushrooms, like polysaccharides, proteins, and other secondary metabolites (such as flavonoids, polyphenols, etc.), have been used to treat multiple diseases, including viral infections, by traditional healers and the medical fraternity. Some edible mushrooms with a high proportion of therapeutic molecules are known as medicinal mushrooms. In this review, an attempt has been made to highlight the exploration of bioactive molecules in mushrooms to combat the various pathophysiological complications of COVID-19. This review presents an in-depth and critical analysis of the current therapies against COVID-19 versus the potential of natural anti-infective, antiviral, anti-inflammatory, and antithrombotic products derived from a wide range of easily sourced mushrooms and their bioactive molecules.

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Role of ACE2-Ang (1–7)-Mas axis in post-COVID-19 complications and its dietary modulation

et al. 2021

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Severe acute respiratory syndrome-coronavirus-2 (COVID-19) virus uses Angiotensin-Converting Enzyme 2 (ACE2) as a gateway for their entry into the human body. The ACE2 with cleaved products have emerged as major contributing factors to multiple physiological functions and pathogenic complications leading to the clinical consequences of the COVID-19 infection Decreased ACE2 expression restricts the viral entry into the human cells and reduces the viral load. COVID-19 infection reduces the ACE2 expression and induces post-COVID-19 complications like pneumonia and lung injury. The modulation of the ACE2-Ang (1–7)-Mas (AAM) axis is also being explored as a modality to treat post-COVID-19 complications. Evidence indicates that specific food components may modulate the AAM axis. The variations in the susceptibility to COVID-19 infection and the post-COVID its complications are being correlated with varied dietary habits. Some of the food substances have emerged to have supportive roles in treating post-COVID-19 complications and are being considered as adjuvants to the COVID-19 therapy. It is possible that some of their active ingredients may emerge as the direct treatment for the COVID-19.

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White Button Mushroom (Agaricus bisporus) Interrupts Tissue AR-TMPRSS2 Expression and Attenuates Pro-inflammatory Cytokines in C57BL/6 Mice: Implication for COVID-19 Dietary Intervention

Cited by 3 publications

References 51 publications

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Polysaccharides and Lectins: A Natural Complementary Approach against the SARS-CoV-2 Pandemic

Therapeutic Potential of Bioactive Compounds from Edible Mushrooms to Attenuate SARS-CoV-2 Infection and Some Complications of Coronavirus Disease (COVID-19)

Role of ACE2-Ang (1–7)-Mas axis in post-COVID-19 complications and its dietary modulation

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