“…During the last four decades many experiments of different type have been conducted to investigate the mechanical properties of the cell (Ananthakrishnan et al, 2006), and especially of the cell membrane, including: micropipette manipulation (Rand, 1964;Chien et al, 1978;Evans, 1983;Engström & Meiselman, 1998;Hochmuth, 2000;Shao & Xu, 2002;Ruef et al, 2004), cell poking (Daily et al, 1984;Duszyk et al, 1989;Goldmann, 2000), shear flow and fluid mechanical technique (Hochmuth et al, 1973;Pfafferott et al, 1985;Kon et al, 1987;Le et al, 1993;Firsov et al, 2006), osmotic expansion and lysis (Evans et al, 1976;Wolfe & Steponkus, 1983;Wolfe et al, 1986;Dowgert et al, 1987), electric field elongation (Engelhardt & Sackmann, 1988;Poznanski et al, 1992;Wanichapichart et al, 2002), magnetic bead microrheometry (Bausch et al, 1998;Wang et al, 2008), dynamic light scattering microscopy (Amin et al, 2007), optical tweezers (Hénon et al, 1999;Dao et al, 2003;Lian et al, 2004;), optical stretcher (Guck et al, 2000;, microplate manipulation (Thoumine et al, 1999;Desprat et al, 2005), and microhand and atomic force microscopy (Yamashina & Katsumata, 2000;Nishi et al, 2005). Some authors have proposed thermodynamics…”