Functionalizing of polyurethane surfaces by photografting with hydrophilic monomers

Guan, Jianjun; Gao, Changyou; Feng, Lianfang; Shen, Jiacong

doi:10.1002/1097-4628(20000912)77:11<2505::aid-app20>3.0.co;2-u

Cited by 52 publications

(30 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[10] Moreover, the N 1s peak at 399.8 eVof the PU-graft-PMAA-graft-RGD is much stronger than that of its precursor, PU-graft-PMAA. The N 1s /C 1s ratio in PU-graft-PMAA-graft-RGD, 5.49, was higher than that of PU-graft-PMAA, 2.05, when the PMAA grafting degree is 21.56 Â 10 À2 mg/cm 2 .…”

Section: Confirmation Of Gelatin or Rgd Peptide Immobilization On Thementioning

confidence: 98%

“…Grafting polymerization was carried out by UV irradiation at a distance of 12.5 cm for 1 h at 35 8C. The grafted membrane was rinsed with hot water (70 8C) for at least 48 h to remove the homopolymers, [9][10][11][12] and subsequently dried under reduced pressure at 50 8C to obtain PU-graft-PMAA.…”

Section: Photo-oxidation and Pre-adsorbing Grafting Polymerizationmentioning

confidence: 99%

“…have been previously grafted on PU and poly(L-lactic acid) (PLLA) surfaces by UV irradiation. [9][10][11][12][13] The introduction of the above-mentioned functional groups generates a more favorable interaction with endothelial cells or chondrocytes accompanied by the increase of surface hydrophilicity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surface Immobilization of Bioactive Molecules on Polyurethane for Promotion of Cytocompatibility to Human Endothelial Cells

Gao

Guan

Zhu

et al. 2003

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

Cytocompatible polymers are of increasing importance for tissue engineering scaffolds and implanted devices. Polyurethane (PU) membranes were modified by grafting polymerization of methacrylic acid (MAA) initiated by UV light and further covalent immobilization of gelatin or arginine‐glycine‐aspartic (RGD) peptide using 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide hydrochloride as a condensing agent. The immobilization of gelatin or RGD peptide was confirmed by FTIR attenuated total reflection (ATR) spectroscopy and X‐ray photoelectron spectroscopy (XPS). The results for endothelial cells cultured in vitro proved that the PU membrane modified with gelatin or RGD peptide had better cytocompatibility than the control PU or the PMAA grafted PU membrane. ATR‐FTIR spectra of PU‐graft‐PMAA (a), PU‐graft‐PMAA‐graft‐RGD (b), and their subtraction result (c). The PMAA grafting degree is 21.56 × 10−2 mg/cm2.magnified imageATR‐FTIR spectra of PU‐graft‐PMAA (a), PU‐graft‐PMAA‐graft‐RGD (b), and their subtraction result (c). The PMAA grafting degree is 21.56 × 10−2 mg/cm2.

show abstract

Section: Confirmation Of Gelatin or Rgd Peptide Immobilization On Thementioning

confidence: 98%

Section: Photo-oxidation and Pre-adsorbing Grafting Polymerizationmentioning

confidence: 99%

See 1 more Smart Citation

Surface Immobilization of Bioactive Molecules on Polyurethane for Promotion of Cytocompatibility to Human Endothelial Cells

Gao

Guan

Zhu

et al. 2003

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

show abstract

“…Hydroperoxide groups could be introduced onto polymer surface by photoxidizing in hydrogen peroxide solution under UV irradiation and would initiate the vinyl monomers grafting copolymerization onto the surface [8]. As could be seen from Fig.…”

Section: Graft Density Measurementsmentioning

confidence: 99%

Enhanced cell affinity of poly(l-lactide) film by immobilizing phosphonized chitosan

Tian

Zhou

Zeng

et al. 2008

Applied Surface Science

View full text Add to dashboard Cite

“…Second, a mechanically enhanced PEG/PAA double-network is a particularly advantageous combination for an optical device due to the hydrophilicity, mutual miscibility, and high protein-resistivity of PEG and PAA (Cruise et al, 1998;Czeslik et al, 2004;Myung et al, 2005;Olabisi et al, 1979;Padmavathi and Chatterji, 1996;Wittemann et al, 2003). Third, PHEA is a hydrophilic, cytocompatible, and rapidly photopolymerizing network that can readily interpenetrate with PEG and PAA and be patterned with high fidelity due to a low degree of swelling after polymerization (Gao et al, 2003;Guan et al, 2000;Moser et al, 1992). Fourth, the application of photolithographic patterning provides both spatial and temporal control over the conversion of a liquid monomer solution into a gel, allowing complex shapes to be fabricated (Albrecht et al, 2005;Liu and Bhatia, 2002;Nguyen and West, 2002;Tsang and Bhatia, 2004).…”

Section: Introductionmentioning

confidence: 99%

Design and fabrication of an artificial cornea based on a photolithographically patterned hydrogel construct

Myung

Koh

Bakri

et al. 2007

Biomed Microdevices

110

View full text Add to dashboard Cite

We describe the design and fabrication of an artificial cornea based on a photolithographically patterned hydrogel construct, and demonstrate the adhesion of corneal epithelial and fibroblast cells to its central and peripheral components, respectively. The design consists of a central "core" optical component and a peripheral tissue-integrable "skirt." The core is composed of a poly(ethylene glycol)/poly(acrylic acid) (PEG/PAA) double-network with high strength, high water content, and collagen type I tethered to its surface. Interpenetrating the periphery of the core is a microperforated, but resilient poly(hydroxyethyl acrylate) (PHEA) hydrogel skirt that is also surface-modified with collagen type I. The well-defined microperforations in the peripheral component were created by photolithography using a mask with radially arranged chrome discs. Surface modification of both the core and skirt elements was accomplished through the use of a photoreactive, heterobifunctional crosslinker. Primary corneal epithelial cells were cultured onto modified and unmodified PEG/PAA hydrogels to evaluate whether the central optic material could support epithelialization. Primary corneal fibroblasts were seeded onto the PHEA hydrogels to evaluate whether the peripheral skirt material could support the adhesion of corneal stromal cells. Cell growth in both cases was shown to be contingent on the covalent tethering of collagen. Successful demonstration of cell growth on the two engineered components was followed by fabrication of core-skirt constructs in which the central optic and peripheral skirt were synthesized in sequence and joined by an interpenetrating diffusion zone.

show abstract

Functionalizing of polyurethane surfaces by photografting with hydrophilic monomers

Cited by 52 publications

References 9 publications

Surface Immobilization of Bioactive Molecules on Polyurethane for Promotion of Cytocompatibility to Human Endothelial Cells

Surface Immobilization of Bioactive Molecules on Polyurethane for Promotion of Cytocompatibility to Human Endothelial Cells

Enhanced cell affinity of poly(l-lactide) film by immobilizing phosphonized chitosan

Design and fabrication of an artificial cornea based on a photolithographically patterned hydrogel construct

Contact Info

Product

Resources

About