Functionalized self-assembling peptide RADKPS hydrogels promote regenerative repair of degenerated intervertebral discs

Tang, Liang; Xu, Chen; Xuan, Anwu; Zhu, Zhenbiao; Ruan, Dike

doi:10.1039/d2bm00634k

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…Further cell delivery optimization may be required to achieve substantial disc height or water content improvement following treatment. For example, combining microscaffolds with an additional hydrogel system like fibrin-genipin, self-assembling peptide, or PNIPAM , as a continuous medium could help increase IVD height and restore NP biomechanical properties . However, conducting clinical trials with novel biomaterials is a highly regulated and resource-intensive process.…”

Section: Resultsmentioning

confidence: 99%

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Nakielski,

Rybak,

Jezierska-Woźniak

et al. 2023

ACS Appl. Mater. Interfaces

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Section: Resultsmentioning

confidence: 99%

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Nakielski,

Rybak,

Jezierska-Woźniak

et al. 2023

ACS Appl. Mater. Interfaces

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“…As well‐documented, small‐sized nanoparticles generally exhibit relatively high accumulation in the kidneys. [ 29 ]…”

Section: Resultsmentioning

confidence: 99%

Engineering of Biodegradable and Excretable Inflammation‐Resolving Materials

Gao

Chun-fan

et al. 2022

Adv Funct Materials

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Uncontrolled or chronic inflammation contributes to the pathogenesis of many acute/chronic diseases, such as acute organ injury, COVID-19, and atherosclerosis. Intrinsically bioactive materials are promising for regulating the response magnitude and duration of inflammation, but their translation remains challenging. Herein, the engineering of a series of inflammation-resolving materials by rationally integrating different functional modules into a hydrolyzable scaffold is reported. The obtained functional materials can assemble into potent anti-inflammatory micelles capable of eliminating different types of reactive oxygen species, releasing bioactive molecules, and simultaneously hydrolyzing into water-soluble and excretable compounds. Cellularly, these micelles effectively inhibit the migration, activation, and production of molecular mediators in inflammatory cells. Benefiting from the small size and high bioactivity, the developed micelles efficiently accumulate in the kidneys of mice with acute kidney injury (AKI) and efficaciously alleviate AKI. Bioactive micelles also demonstrate desirable targeting and superior efficacies in mice with acute liver failure. Mechanistically, inhibition of oxidative damage, attenuation of inflammatory cell infiltration and activation, and promoting resolution of inflammation mainly account for beneficial therapeutic effects of micelles. Moreover, preliminary studies reveal the excellent safety of micelles. Consequently, the bioactive materials represent a new type of efficacious, safe, scalable, and affordable therapy for a broad spectrum of inflammatory diseases.

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“…Notably, the utilization of bioactive peptides for the regulation of IVD cells and enhancement of IDD processes has garnered growing interest in recent times. Tang et al (2022) delivered three short peptide fragments, SNVI, KPSS, and KAIS, which have the biological activity of bone morphogenetic protein-7. They found that KPSS exhibited the most potent biological activity and most extended duration of action.…”

Section: Therapeutic Factorsmentioning

confidence: 99%

“… Ligorio et al (2021) used a self-assembled peptide FEFKFEFK (F: phenylalanine; K: lysine; E: glutamic acid) to construct a hydrogel and tried to treat IDD with GO-loaded TGF-β3, clearly indicating that GO reinforces the mechanical structure of self-assembled peptides and enables TGF-β3 slowly release. In another study, Tang et al (2022) used self-assembled peptides as hydrogel substrates and directly modified bioactive polypeptide fragments on self-assembled peptides.…”

Section: Delivery Platforms For Therapeutic Factorsmentioning

confidence: 99%

Therapeutic factors and biomaterial-based delivery tools for degenerative intervertebral disc repair

Song,

Guo,

et al. 2024

Front. Cell Dev. Biol.

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Intervertebral disc degeneration (IDD) is the main cause of low back pain (LBP), which significantly impacts global wellbeing and contributes to global productivity declines. Conventional treatment approaches, encompassing conservative and surgical interventions, merely serve to postpone the advancement of IDD without offering a fundamental reversal. Consequently, there is an urgent demand for an effective approach to prevent the progression of IDD. Recent investigations focusing on the treatment of IDD utilizing diverse bioactive substances integrated within various biomaterials have exhibited promising outcomes. Various bioactive substances, encompassing conventional small molecule drugs, small molecule nucleic acids, and cell therapies, exhibit distinct capacities for repairing IDD. Additionally, various biological material delivery systems, such as nano micelles, microspheres, and hydrogels, possess diverse biological and release characteristics. Consequently, these diverse materials and drugs hold promise for advancing the treatment of IDD. This article aims to provide a concise overview of the IDD process and investigate the research advancements in biomaterials and bioactive substances for IDD treatment, delving into their mechanisms.

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Functionalized self-assembling peptide RADKPS hydrogels promote regenerative repair of degenerated intervertebral discs

Abstract: Objective: The aim of this study was to investigate whether the functionalized self-assembling peptide hydrogel RADKPS is safe and effective for regenerative repair of degenerative intervertebral discs.Methods: An in vitro...

Cited by 8 publications

References 52 publications

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Minimally Invasive Intradiscal Delivery of BM-MSCs via Fibrous Microscaffold Carriers

Engineering of Biodegradable and Excretable Inflammation‐Resolving Materials

Therapeutic factors and biomaterial-based delivery tools for degenerative intervertebral disc repair

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