Engineering of Biodegradable and Excretable Inflammation‐Resolving Materials

Abstract

Uncontrolled or chronic inflammation contributes to the pathogenesis of many acute/chronic diseases, such as acute organ injury, COVID-19, and atherosclerosis. Intrinsically bioactive materials are promising for regulating the response magnitude and duration of inflammation, but their translation remains challenging. Herein, the engineering of a series of inflammation-resolving materials by rationally integrating different functional modules into a hydrolyzable scaffold is reported. The obtained functional materials can assemble into potent anti-inflammatory micelles capable of eliminating different types of reactive oxygen species, releasing bioactive molecules, and simultaneously hydrolyzing into water-soluble and excretable compounds. Cellularly, these micelles effectively inhibit the migration, activation, and production of molecular mediators in inflammatory cells. Benefiting from the small size and high bioactivity, the developed micelles efficiently accumulate in the kidneys of mice with acute kidney injury (AKI) and efficaciously alleviate AKI. Bioactive micelles also demonstrate desirable targeting and superior efficacies in mice with acute liver failure. Mechanistically, inhibition of oxidative damage, attenuation of inflammatory cell infiltration and activation, and promoting resolution of inflammation mainly account for beneficial therapeutic effects of micelles. Moreover, preliminary studies reveal the excellent safety of micelles. Consequently, the bioactive materials represent a new type of efficacious, safe, scalable, and affordable therapy for a broad spectrum of inflammatory diseases.

Catalytic reactivity descriptors of metal‐nitrogen‐doped carbon catalysts for electrocatalysis

“…They established a descriptor, denoted as ϕ, which includes the valence electrons number of the d orbital in the metal atom site, electronegativity of metal atom, and the number of C/N atom around the metal site. This high‐throughput design approach reveals intrinsic descriptors that correlate the catalytic activity of M‐N‐C‐based DACs with their electronic structures and bonding carbon surface structure 142 …”

“…Copyright 2019 American Chemical Society. (B) The schematic of 16 767 possible combinations of M‐N‐C‐based DAC 142 . Copyright 2022 Wiley‐VCH.…”

Neutrophil Membrane-Inspired Nanorobots Act as Antioxidants Ameliorate Ischemia Reperfusion-Induced Acute Kidney Injury

“…Significant advances in nanotechnology have considerably inspired the technological innovation in antioxidant therapy of ROS-related diseases. − In the past decades, various functional nanomaterials, such as organic nanoparticles, inorganic nanoparticles, and organic/inorganic hybrid nanoparticles, − hold intrinsic strong antioxidant capabilities by directly capturing ROS and/or enzyme-like antioxidant catalytic reactions have been developed to treat AKI diseases. Cu NPs and cuprous oxide (Cu 2 O) NPs possess good catalytic activity; Deng’s research group combined Cu 2 O and Cu nanocrystals to achieve broader-spectrum enzymatic catalytic properties and antioxidant activities.…”

Durable Immunomodulatory Nanofiber Niche for the Functional Remodeling of Cardiovascular Tissue

“…Therefore, a niche with prolonged effectiveness is critical for the successful regeneration of cardiovascular tissue. In previous studies, anti-inflammatory small molecules and interfering RNAs have been incorporated into scaffolds by coating or direct blending. , However, the release half-life of these active ingredients has generally been less than 1 week. Hence, a stable anti-inflammatory niche for the repair of cardiovascular tissue damage remains elusive.…”