Functionalized poly(ether ether ketone): Improved mechanical property and acellular bioactivity

Pramanik, Sumit; Kar, Kamal K.

doi:10.1002/app.34582

Cited by 35 publications

(42 citation statements)

References 36 publications

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“…(2)2933. The crystallite size (t) (Figure 2C) was derived from the XRD result using the Debye Scherrer formula34 by neglecting the crystal strain value, i.e., <0.25%24 (see Eq.…”

Section: Resultsmentioning

confidence: 99%

Design and Development of Potential Tissue Engineering Scaffolds from Structurally Different Longitudinal Parts of a Bovine-Femur

Pramanik

Pingguan‐Murphy

Cho

et al. 2014

Sci Rep

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The complex architecture of the cortical part of the bovine-femur was examined to develop potential tissue engineering (TE) scaffolds. Weight-change and X-ray diffraction (XRD) results show that significant phase transformation and morphology conversion of the bone occur at 500–750°C and 750–900°C, respectively. Another breakthrough finding was achieved by determining a sintering condition for the nucleation of hydroxyapatite crystal from bovine bone via XRD technique. Scanning electron microscopy results of morphological growth suggests that the concentration of polymer fibrils increases (or decreases, in case of apatite crystals) from the distal to proximal end of the femur. Energy-dispersive analysis of X-ray, Fourier transform infrared, micro-computer tomography, and mechanical studies of the actual composition also strongly support our microscopic results and firmly indicate the functionally graded material properties of bovine-femur. Bones sintered at 900 and 1000°C show potential properties for soft and hard TE applications, respectively.

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“…(2)2933. The crystallite size (t) (Figure 2C) was derived from the XRD result using the Debye Scherrer formula34 by neglecting the crystal strain value, i.e., <0.25%24 (see Eq.…”

Section: Resultsmentioning

confidence: 99%

Design and Development of Potential Tissue Engineering Scaffolds from Structurally Different Longitudinal Parts of a Bovine-Femur

Pramanik

Pingguan‐Murphy

Cho

et al. 2014

Sci Rep

Self Cite

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show abstract

“…This asymmetric structure helps to increase the mobility of polymer chains, and therefore reduces the crystallinity and mechanical properties of the polymer. A more detailed explanation of this new finding is given in the original report [80].…”

Section: Strategy For Selection Of Scaffold Materials To Improve Mechmentioning

confidence: 99%

“…The mechanical properties of copolymers can be improved by increasing the size of crystalline domains [81], molecular bond strength [82], tacticity or stereographic position [80], hydrophilicity [83] and so on. In copolymerization, the molecular bond strength is increased by grafting between different polymers, which in turn increases the mechanical properties of bulk copolymer.…”

Section: Copolymerizationmentioning

confidence: 99%

“…A few recent studies have shown that the mechanical properties of the bulk polymers or fibrous polymers can be improved by several surface treatment techniques [80,86]. The polymer surface is effectively modified with polar groups containing ester (-COOR), ether (-O-), ketone (>CO), epoxy, carboxylic acid (-COOH), hydroxyl (-OH), acetyl (-COCH 3 ), amide (-CONH 2 ), amine (-NH 2 ) or other moieties by a suitable surface treatment.…”

Section: Surface Treatmentmentioning

confidence: 99%

“…However, their limited solubility (e.g. for chitosan, polyether ether ketone) hinders electrospinning [80,89]. Their good mechanical properties originate from the network structure and strong hydrogen bonding.…”

Section: Composite Fabrication or Hybridizationmentioning

confidence: 99%

See 2 more Smart Citations

Progress of key strategies in development of electrospun scaffolds: bone tissue

Pramanik

Pingguan‐Murphy

Osman

2012

Science and Technology of Advanced Materials

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There has been unprecedented development in tissue engineering (TE) over the last few years owing to its potential applications, particularly in bone reconstruction or regeneration. In this article, we illustrate several advantages and disadvantages of different approaches to the design of electrospun TE scaffolds. We also review the major benefits of electrospun fibers for three-dimensional scaffolds in hard connective TE applications and identify the key strategies that can improve the mechanical properties of scaffolds for bone TE applications. A few interesting results of recent investigations have been explained for future trends in TE scaffold research.

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In vivo biocompatibility and bioactivity of in situ synthesized hydroxyapatite/polyetheretherketone composite materials

Weng

Bao

et al. 2012

J of Applied Polymer Sci

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Hydroxyapatite/polyetheretherketone (HA/PEEK) composite materials were prepared via an in situ synthesis process in order to achieve strong bonding between PEEK matrix and hydroxyapatite fillers, and ultimately to improve the mechanical properties of the composites. In the study, the biocompatibility of the synthesized HA/PEEK materials was investigated by acute toxicity test, hemolytic test, sensitization test, pyrogen test, intradermal test, and toxicity assay test on animal tissue and cells for the purpose of examining the possible adverse effects of the residue organic chemicals from the in situ synthesis process. In vivo bioactivity of both lab‐synthesized PEEK and HA/PEEK composites with various HA content was also studied. It is found that the in situ synthesized composite materials possess good biocompability without toxicity. Although the bioactivity of the material increases with HA content, the composite material with 5.6 vol % HA exhibits satisfactory bioactivity without compromising its excellent mechanical performance, which hints to a potential use as load‐bearing orthopedic material. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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Functionalized poly(ether ether ketone): Improved mechanical property and acellular bioactivity

Cited by 35 publications

References 36 publications

Design and Development of Potential Tissue Engineering Scaffolds from Structurally Different Longitudinal Parts of a Bovine-Femur

Design and Development of Potential Tissue Engineering Scaffolds from Structurally Different Longitudinal Parts of a Bovine-Femur

Progress of key strategies in development of electrospun scaffolds: bone tissue

In vivo biocompatibility and bioactivity of in situ synthesized hydroxyapatite/polyetheretherketone composite materials

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