Progress of key strategies in development of electrospun scaffolds: bone tissue

Pramanik, Sumit; Pingguan‐Murphy, Belinda; Osman, Noor Azuan Abu

doi:10.1088/1468-6996/13/4/043002

Cited by 57 publications

(42 citation statements)

References 104 publications

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“…70 Some advantages of electrospun scaffolds include the presence of high surface area for cell attachment and high porosity to facilitate nutrient and waste exchange. [71][72][73] Solution electrospinning is also a simple and inexpensive scaffold fabrication technique, and a wide range of polymeric solutions can be used to fabricate the scaffolds. However, the main disadvantage of electrospinning is the involvement of toxic organic solvents during fabrication, which can be harmful to cells.…”

Section: Electrospinningmentioning

confidence: 99%

Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size

Loh

Choong

2013

Tissue Engineering Part B: Reviews

2,065

1,446

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Tissue engineering applications commonly encompass the use of three-dimensional (3D) scaffolds to provide a suitable microenvironment for the incorporation of cells or growth factors to regenerate damaged tissues or organs. These scaffolds serve to mimic the actual in vivo microenvironment where cells interact and behave according to the mechanical cues obtained from the surrounding 3D environment. Hence, the material properties of the scaffolds are vital in determining cellular response and fate. These 3D scaffolds are generally highly porous with interconnected pore networks to facilitate nutrient and oxygen diffusion and waste removal. This review focuses on the various fabrication techniques (e.g., conventional and rapid prototyping methods) that have been employed to fabricate 3D scaffolds of different pore sizes and porosity. The different pore size and porosity measurement methods will also be discussed. Scaffolds with graded porosity have also been studied for their ability to better represent the actual in vivo situation where cells are exposed to layers of different tissues with varying properties. In addition, the ability of pore size and porosity of scaffolds to direct cellular responses and alter the mechanical properties of scaffolds will be reviewed, followed by a look at nature's own scaffold, the extracellular matrix. Overall, the limitations of current scaffold fabrication approaches for tissue engineering applications and some novel and promising alternatives will be highlighted.

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Section: Electrospinningmentioning

confidence: 99%

Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size

Loh

Choong

2013

Tissue Engineering Part B: Reviews

2,065

1,446

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“…Tissue engineering multi-factor strategies are still amongst promising approaches for repair of cartilage defects. Apart from the selection of suitable cells and growth factors, use of proper scaffolds with appropriate physiochemical structure [1] will favor biocompatibility and cell adhesion/proliferation. The scaffolds must possess suitable geometry and mechanical properties [2], high porosity and interconnectivity, stability and consistency of mechanical strength, and a proper surface micro-morphology [1].…”

Section: Introductionmentioning

confidence: 99%

A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications

Moradi

Pramanik

Ataollahi

et al. 2014

Science and Technology of Advanced Materials

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Native cartilage matrix derived (CMD) scaffolds from various animal and human sources have drawn attention in cartilage tissue engineering due to the demonstrable presence of bioactive components. Different chemical and physical treatments have been employed to enhance the micro-architecture of CMD scaffolds. In this study we have assessed the typical effects of physical cross-linking methods, namely ultraviolet (UV) light, dehydrothermal (DHT) treatment, and combinations of them on bovine articular CMD porous scaffolds with three different matrix concentrations (5%, 15% and 30%) to assess the relative strengths of each treatment. Our findings suggest that UV and UV–DHT treatments on 15% CMD scaffolds can yield architecturally optimal scaffolds for cartilage tissue engineering.

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“…Electrospun fibers with diameters between several tens to several hundred nanometers can be obtained and electrospun materials have become more widely including polymers, mixtures, semiconductors, ceramics, etc, that has directly contributed to wide applications of electrospun fibers in scientific research and production practice. Now electrospun fibers have been broadly used in human tissue regeneration scaffold [2], drug release system, various types of battery, catalyst and sensors, etc. A set of conventional electrostatic spinning apparatus is shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Applications of Electrospun Fibers in Sensors

Zhu¹,

Wang²

2017

Proceedings of the 2017 7th International Conference on Education, Management, Computer and Society (EMCS 2017)

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Abstract. Electrospun fibers with many advantages such as nano-structure, large specific surface area, high porosity, have been widely applied in the field of sensors. This paper mainly introduces latest development of electrospun fiber applications in biosensors, gas sensors and metal ion sensors. Biosensors are introduced according to the types of sensitive materials (enzyme, metal oxides, other biological materials except enzyme) immobilizated on electrospun fibers. Gas sensors based on electrospun fibers are simply summaried in organic gas sensors and inorganic gas sensors, and some typical examples are introduced. Some novel copper ion sensors based on electrospun fibers are also discussed to example for the electrospun fiber applications in metal ion sensors. In the conclusion part, two aspects are proposed to improve the applications of electrospun fibers in sensors.

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Progress of key strategies in development of electrospun scaffolds: bone tissue

Cited by 57 publications

References 104 publications

Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size

Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size

A comparison study of different physical treatments on cartilage matrix derived porous scaffolds for tissue engineering applications

Applications of Electrospun Fibers in Sensors

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