Functionalization of gold nanoparticles as antidiabetic nanomaterial

Venkatachalam, M.; Govindaraju, K.; Sadiq, A. Mohamed; Selvaraj, Thangavel; Kumar, V. Ganesh; Ganesan, Singaravelu

doi:10.1016/j.saa.2013.07.038

Cited by 90 publications

(33 citation statements)

References 42 publications

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“…Digestive enzyme, α-glucosidase can release glucose by hydrolyzing starch rapidly, resulting in postprandial hyperglycemia to diabetic patients. Therefore, Identifying and describing the inhibitors of α-glucosidase various sources that can be used significantly in medicine [9,10]. Application of metal nanoparticles in this fast-growing field has placed the source to the find the alternative methods to postprandial hyperglycemia.…”

Section: Introductionmentioning

confidence: 99%

Facile green synthesis of gold nanoparticles from marine algae Gelidiella acerosa and evaluation of its biological Potential

Senthilkumar¹,

Surendran²,

Sudhagar³

et al. 2019

SN Appl. Sci.

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In this present research, the Gold nanoparticles (GA-AuNPs) produced from Gelidiella acerosa, marine algae using green synthesis method was evaluated for its antidiabetic, antibacterial and antioxidant activity. Well-developed GA-AuNPs were effectively characterized using advanced analytical instruments like HRTEM, UV-visible, SEM and XRD. This analysis exposed GA-AuNPs to be present with spherical, hexagonal structure and crystalline nature. The average size of GA-AuNPs particles was estimated to lie between 5.81 nm to 117.59 nm by using Debye-Scherer equation. The enzyme inhibitory property of (IC 50 ) of G. acerosa aqueous extract and synthesized gold nanoparticles from G. acerosa against α amylase and α-glucosidase enzyme was found to be 2.1 ± 0.01, 3.7 ± 0.01 µg/mL and 2.8 ± 0.02, 4.1 ± 0.01, respectively. Further antioxidant assessment of GA-AuNPs were examined using DPPH and FRAP assays, the results exhibited that the strong antioxidant activity were observed in all the concentrations when compared with standard. Finally antibacterial activity was evaluated the GA-AuNPs against gram positive and gram negative bacteria, the strong antibacterial activity was observed in both the bacterial strains when compared with standard antibiotic. The GA-AuNPs from marine algae was exhibited to be strong inhibitory activity against alpha amylase and alpha glucosidase enzyme, antioxidant activity and antibacterial activity, these GA-AuNPs are projected to have potential biological applications.

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Section: Introductionmentioning

confidence: 99%

Facile green synthesis of gold nanoparticles from marine algae Gelidiella acerosa and evaluation of its biological Potential

Senthilkumar¹,

Surendran²,

Sudhagar³

et al. 2019

SN Appl. Sci.

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“…Current nanotechnology is involved in a number of emerging biomedical applications, since it provides unequalled technological solutions to health problems [3], extensively therapeutics akin to the targeted drug therapy [4], tissue regeneration [5], cardiac therapy [6], cancer therapy [7], diabetic therapeutics [8], and very useful for biosensors [9], antimicrobials and as well in the field of molecular biology and parasitology [10]. Equally, nanotech has driven a route for multidisciplinary fields such as electronics, aerospace engineering, food technology, sensing and photonics [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Green-Synthesis of Selenium Nanoparticles Using Garlic Cloves (Allium sativum): Biophysical Characterization and Cytotoxicity on Vero Cells

et al. 2016

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Nanotechnology has the potential to revolutionize a number of research fields, including biomedicine. Currently, the fabrication of biocompatible nanomaterials is of high interest worldwide. Little is known about the possible synthetic routes to fabricate selenium nanoparticles. In this research, we focused on the potential of a medicinally important plant species, garlic (Allium sativum), for the green synthesis of selenium nanoparticles. The garlic aqueous extracts acted as a capping and reducing agent in forming selenium nanoparticles. Green-synthesized selenium nanoparticles were characterized using UV-vis spectrophotometry, TEM, SEM, EDAX, FTIR and XRD analysis. Furthermore, green-fabricated and conventional chemically synthesized selenium nanoparticles were tested to evaluate their cytotoxicity against Vero cells. CC 50 values revealed that biologically synthesized selenium nanoparticles showed eco-friendly features and limited cytotoxicity if compared with chemically synthesized selenium nanoparticles.

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“…2-(3-Acetoxy-4,4,14-trimethyl androst-8-en-17-yl) propanoic acid was reported to be an antibacterial agent [22]. Moreover, this compound was also reported to be a potential protein tyrosine phosphatase 1B (PTP 1B) inhibitor and considered to be a potential therapeutic agent for the treatment of type-II diabetes [23].…”

Section: Resultsmentioning

confidence: 99%

GC-MS Profiling of Capsaicinoids Present in Capsicum chinense Jacq. cv. (Naga King Chilli) and Evaluation of its Antifungal Activity

Levono¹,

Prasad²

2017

Asian J. Chem.

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Functionalization of gold nanoparticles as antidiabetic nanomaterial

Cited by 90 publications

References 42 publications

Facile green synthesis of gold nanoparticles from marine algae Gelidiella acerosa and evaluation of its biological Potential

Facile green synthesis of gold nanoparticles from marine algae Gelidiella acerosa and evaluation of its biological Potential

Green-Synthesis of Selenium Nanoparticles Using Garlic Cloves (Allium sativum): Biophysical Characterization and Cytotoxicity on Vero Cells

GC-MS Profiling of Capsaicinoids Present in Capsicum chinense Jacq. cv. (Naga King Chilli) and Evaluation of its Antifungal Activity

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