Functional Zwitterionic Polymers on Surface: Structures and Applications

Li, Minglun; Zhuang, Bilin; Yu, Jing

doi:10.1002/asia.202000547

Cited by 58 publications

(50 citation statements)

References 113 publications

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“…Known as the antipolyelectrolyte effect, salt ions can shield charges in zwitterionic polymers. This leads to an increase in solubility and thus a sharp drop in UCST until the thermoresponsive behavior eventually disappears completely even at relatively low ionic strength [ 50 , 281 , 322 ]. This phenomenon still hinders the wide use of zwitterionic polymers in physiological media for biomedical applications, although they have long been known for their sharp and reversible UCST-type behavior in water.…”

Section: Reviewmentioning

confidence: 99%

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Flemming¹,

Münch²,

Fery³

et al. 2021

Beilstein J. Org. Chem.

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In the last decades, numerous stimuli-responsive polymers have been developed and investigated regarding their switching properties. In particular, thermoresponsive polymers, which form a miscibility gap with the ambient solvent with a lower or upper critical demixing point depending on the temperature, have been intensively studied in solution. For the application of such polymers in novel sensors, drug delivery systems or as multifunctional coatings, they typically have to be transferred into specific arrangements, such as micelles, polymer films or grafted nanoparticles. However, it turns out that the thermodynamic concept for the phase transition of free polymer chains fails, when thermoresponsive polymers are assembled into such sterically confined architectures. Whereas many published studies focus on synthetic aspects as well as individual applications of thermoresponsive polymers, the underlying structure–property relationships governing the thermoresponse of sterically constrained assemblies, are still poorly understood. Furthermore, the clear majority of publications deals with polymers that exhibit a lower critical solution temperature (LCST) behavior, with PNIPAAM as their main representative. In contrast, for polymer arrangements with an upper critical solution temperature (UCST), there is only limited knowledge about preparation, application and precise physical understanding of the phase transition. This review article provides an overview about the current knowledge of thermoresponsive polymers with limited mobility focusing on UCST behavior and the possibilities for influencing their thermoresponsive switching characteristics. It comprises star polymers, micelles as well as polymer chains grafted to flat substrates and particulate inorganic surfaces. The elaboration of the physicochemical interplay between the architecture of the polymer assembly and the resulting thermoresponsive switching behavior will be in the foreground of this consideration.

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Section: Reviewmentioning

confidence: 99%

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Flemming¹,

Münch²,

Fery³

et al. 2021

Beilstein J. Org. Chem.

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show abstract

“…Since many researchers have reported that zwitterionic polymers show antifouling effects, they have been used for coating surfaces of medical devices and drug delivery systems. [ 1–4 ] Moreover, some zwitterionic polymers afford upper critical solution temperature (UCST)‐type temperature‐sensitive properties; hence, they are applicable as smart materials. [ 3,4 ] Hydrogels fabricated from zwitterionic polymers also show antifouling and thermosensitive properties; hence, they have been used as implant materials, temperature‐responsive drug containers, etc.…”

Section: Introductionmentioning

confidence: 99%

“…[ 3,4 ] Hydrogels fabricated from zwitterionic polymers also show antifouling and thermosensitive properties; hence, they have been used as implant materials, temperature‐responsive drug containers, etc. [ 1–3 ] Since zwitterionic polymers interact with each other due to the electrostatic interactions, zwitterionic polymer hydrogels exhibit self‐healing properties. [ 1–3 ] Thus, they have great potential for various kinds of applications, especially in biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

Application of Zwitterionic Polymer Hydrogels to Optical Tissue Clearing for 3D Fluorescence Imaging

Kojima

Koda

Nariai

et al. 2021

Macromolecular Bioscience

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Zwitterionic polymers have both anion and cation groups in the side chain and have been used in various biomedical applications because of the unique properties. In this study, zwitterionic polymer hydrogels are applied to optical tissue clearing for 3D fluorescence imaging. Polyacrylamide hydrogels have been employed in Clear Lipid‐exchanged Acrylamide‐hybridized Rigid Imaging/Immunostaining/In situ‐hybridization‐compatible Tissue‐hYdrogel method. Zwitterionic polymer hydrogels are produced using zwitterionic monomers, such as 3‐[(3‐acrylamidopropyl)dimethylammonio]propane‐1‐sulfonate (DAPS) and 2‐methacryloyloxyethyl phosphorylcholine (MPC), and crosslinkers. The hydrogels made from poly(DAPS‐co‐acrylamide) and MPC homopolymers afford the most transparent tumor tissues. However, the tissues cleared using DAPS copolymers‐containing hydrogels became turbid in a refractive index‐matching solution, which are unable to obtain clear 3D fluorescence images. In contrast, the 3D fluorescence imaging is achieved in the MPC polymer‐treated 2‐mm‐thick brain slices after immunostaining. The 3D fluorescence imaging of lung metastasis that is cleared by the MPC hydrogel to demonstrate the possible application to cancer diagnosis is performed. The results indicate the increased potentials of zwitterionic polymer hydrogels, especially MPC polymer hydrogels, in biomedical applications.

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“…The commercial interest for these polymers is determined by their possibility to be used as polymeric sorbents, oil recovery agents, fungicides, flame retardant polymers, emulsifying agents, wetting agents, cleaning agents and cryoprotectants [23][24][25]. Polymers having various betaine structure were synthesized in order to obtain materials sensitive to different stimuli (pH, temperature, etc.)…”

Section: Introductionmentioning

confidence: 99%

New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems

Racoviţă¹,

Baranov

Macsim³

et al. 2020

Molecules

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New grafted copolymers possessing structural units of 1-vinyl-3-(1-carboxymethyl) imidazolium betaine were obtained by graft copolymerization of N-vinylimidazole onto gellan gum followed by the polymer-analogous reactions on grafted polymer with the highest grafting percentage using sodium chloroacetate as the betainization agent. The grafted copolymers were prepared using ammonium persulfate/N,N,N′,N′ tetramethylethylenediamine in a nitrogen atmosphere. The grafting reaction conditions were optimized by changing one of the following reaction parameters: initiator concentration, monomer concentration, polymer concentration, reaction time or temperature, while the other parameters remained constant. The highest grafting yield was obtained under the following reaction conditions: ci = 0.08 mol/L, cm = 0.8 mol/L, cp = 8 g/L, tr = 4 h and T = 50 °C. The kinetics of the graft copolymerization of N-vinylimidazole onto gellan was discussed and a suitable reaction mechanism was proposed. The evidence of the grafting reaction was confirmed through FTIR spectroscopy, X-ray diffraction, 1H-NMR spectroscopy and scanning electron microscopy. The grafted copolymer with betaine structure was obtained by a nucleophilic substitution reaction where the betainization agent was sodium chloroacetate. Preliminary results prove the ability of the grafted copolymers to bind amphoteric drugs (cefotaxime) and, therefore, the possibility of developing the new sustained drug release systems.

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Functional Zwitterionic Polymers on Surface: Structures and Applications

Cited by 58 publications

References 113 publications

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Constrained thermoresponsive polymers – new insights into fundamentals and applications

Application of Zwitterionic Polymer Hydrogels to Optical Tissue Clearing for 3D Fluorescence Imaging

New Grafted Copolymers Carrying Betaine Units Based on Gellan and N-Vinylimidazole as Precursors for Design of Drug Delivery Systems

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