Functional Properties of Walnut in Cosmetics

Kim, Mee Kyoung; Kim, Jin-Sung; Jo, Bun-Sung; Kim, Jeung-Hoan; Lee, In-Cheol; Lee, Myung-Sup; Cho, Young-Je

doi:10.5352/jls.2011.21.6.858

Cited by 8 publications

(3 citation statements)

References 16 publications

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“…In this study, Eleutherococcus senticosus was used instead of Psoralea corylifolia, because it is non-toxic with multiple purposes for treatment of the musculoskeletal system. In Korean medicine, Juglans regia has been reported to have antioxidant effects and analgesic effects [9]. Eucommia ulmoides is used to treat lower back, and knee pain in Korean medicine, strengthening muscles and bones, and stabilizing the fetus [10].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effects of Complex Extract including Eucommia ulmoides in LPS-induced RAW 264.7 Cells

et al. 2019

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Background: The purpose of this study was to investigate the anti-inflammatory response of lipopolysaccharide (LPS) activated macrophages (RAW 264.7 murine cell line) to JCE003 which is an extract including Eucommia ulmoides, Juglans regia, Eleutherococcus senticosus, and Zingiber officinale. Methods: An MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] assay was performed to analyze the survival rate of RAW 264.7 cells. The production of nitric oxide and proinflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6) in LPS-induced RAW 264.7 cells was measured by enzyme-linked immunosorbent assay. mRNA expression levels of pro-inflammatory cytokines (IFN-γ, TNF-α, IL-1β, and IL-6) were analyzed by quantitative polymerase chain reaction analysis. Results: Exposure of LPS-activated RAW 264.7 cells to JCE003 was not cytotoxic up to 400 μg/mL, but cell survival was statistically significantly decreased at 800 μg/mL (p < 0.001). Nitric oxide production was not markedly lowered in LPS-activated RAW 264.7 cells by exposure to JCE003 (10, 50, 100, 200, 400, 800 μl/mL) compared with the Control group. In addition, JCE003 reduced the production of TNF-α in LPS-induced RAW 264.7 cells at 400 μg/mL (p < 0.05), but IFN-γ and TNF-α mRNA expression in LPS-induced RAW 264.7 cells was decreased at 100, 200, and 400 μg/mL JCE003 (p < 0.01). Conclusion: These results suggest that JCE003 inhibited the expression and production of pro-inflammatory cytokines in LPS-activated RAW 264.7 cells. The findings of this study provide basic data for the development of new Korean medicine anti-inflammatory drugs.

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Effects of Complex Extract including Eucommia ulmoides in LPS-induced RAW 264.7 Cells

et al. 2019

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“…Juglandis semen has been reported in various studies for its antioxidant and analgesic effects. [11] Additionally, Eucommia ulmoides shows antioxidant activity and has anti-inflammatory effect. [12,13] Acanthopanax sessiliflorum is known to be effective for neuralgia, joint pain, and bruises.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Juglandis semen complex extract for knee osteoarthritis

Kong

Kang

2019

Medicine

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Background: Knee osteoarthritis (KOA) is a common disease in elderly individuals. Many medications for KOA have the potential to cause side effects. We used Juglandis semen complex extract (JCE) consisting of 4 herbs derived from Cheong-A-Won, which has been commonly used for KOA treatment. In this study, we will evaluate whether JCE improves symptoms in patients with KOA and will identify the changes in the inflammation factor. Methods: This study will be a single-center, randomized, double-blind, and placebo-controlled trial. Three groups, JCE 1000 mg, 2000 mg, and placebo, will be randomly allocated. Total duration of the clinical trial will be 12 to 14 weeks. Study participants will be followed up every 6 weeks and the effect and safety will be assessed at the 2 nd , 3 rd , and 4 th visit. All participants were asked to maintain a dosage schedule for this protocol. The primary outcomes will be measured using Korean Western Ontario and McMaster Universities Questionnaire and the secondary outcomes will include pain Visual analog scale score, EuroQol Five Dimensions questionnaire, Patient Global Impression of Change, and the changes in the laboratory test parameters of inflammation. Repeated-measure analysis will be used to measure primary efficacy based on full analysis set. Discussion: This study has limited inclusion and exclusion criteria and a well-controlled intervention, and it will be the first randomized controlled trial to assess the efficacy and safety of JCE in patients with KOA. This study provides insights into the mechanisms that explain the therapeutic effects of JCE in KOA and will lay the groundwork for further studies.

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“…논란과 (Ramarathnam et al, 1995;Omaye et al, 1977), 웰빙이 라는 문화적 이슈로 인한 인공 합성물에 대한 인식의 변화로 (Kim et al, 2011), 민간이나 한의학에서 질병예방 및 치료의 목적으로 이용하던 천연물을 활용하여 보다 안전한 향장제품의 개발이 활 발히 이루어지고 있다 (Seo et al, 2013;Lee et al, 1998;Moure et al, 2001). 꾸지뽕나무(Curdrania tricuspidata)는 뽕나무과(Moraceae)에 속하는 낙엽활엽 소교목으로 우리나라를 비롯한 동아시아 지역에 주로 분포하고 있으며, 줄기에는 가시가 있고 9-10월에 붉은 열매 를 맺는 특징이 있다 (Kim et al, 2009;Choi et al, 2009;Jung, 1965).…”

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Development of Whitening Cosmetic Ingredients from Cudrania tricuspidata Stem Extract

Han¹,

Kim²,

Lim³

et al. 2016

Asian J Beauty Cosmetol

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This study was conducted to investigate the possibility of Cudrania tricuspidata (C. tricuspidata) stem extract as whitening cosmetic material. Methods: We performed TLC and HPLC analysis to investigate the anti-oxidant compounds and its contents in C. tricuspidata stem extract fractions (hexane, ethyl acetate, butanol, and water). In order to evaluate anti-oxidant effects, radical and superoxide scavenging activities were conducted by using DPPH, ABTS free radicals and xanthine oxidases, respectively. In addition, we examined tyrosinase activity and cellular melanin content to verify the whitening effects of C. tricuspidata stem extract. Results: We found out that both ethyl acetate fraction and butanol fraction among the fractions of C. tricuspidata stem extract had anti-oxidant compounds. Our results pointed out that the active fractions have significant free radical and superoxide scavenging activities, and the fraction of ethyl acetate is the best. The ethyl acetate fraction (IC 50 24.4 ppm) and butanol fraction (IC 50 88.3 ppm) reduced tyrosinase activities and melanin content in a concentration-dependent manner. Conclusion: Through the results, C. tricuspidata stem extract has the potent as a cosmetic material which possess the anti-oxidant and whitening effects.

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Functional Properties of Walnut in Cosmetics

Cited by 8 publications

References 16 publications

Anti-inflammatory Effects of Complex Extract including Eucommia ulmoides in LPS-induced RAW 264.7 Cells

Anti-inflammatory Effects of Complex Extract including Eucommia ulmoides in LPS-induced RAW 264.7 Cells

Efficacy of Juglandis semen complex extract for knee osteoarthritis

Development of Whitening Cosmetic Ingredients from Cudrania tricuspidata Stem Extract

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