Functional Connectivity Density Mapping of Depressive Symptoms and Loneliness in Non-Demented Elderly Male

Lan, Chen-Chia; Tsai, Shih Jen; Huang, Chu-Chung; Wang, Ying Hsiu; Chen, Tong Ru; Yeh, Heng Liang; Liu, Mu En; Lin, Ching Po; Yang, Albert C.

doi:10.3389/fnagi.2015.00251

Cited by 33 publications

(21 citation statements)

References 58 publications

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“…In an animal study, isolation from caregivers was found to induce more intense neural activity in ITG (Rilling et al , 2001 ). Depressive symptom, which is often concurrent with higher loneliness (Cacioppo et al , 2006 ), was related with increased functional connectivity density in ITG (Lan et al , 2015 ) and increased regional cerebral blood flow in ITG (Van Heeringen et al , 2010 ). These findings converge to suggest that the neural activity of ITG may be a potential neuroimaging biomarker of loneliness.…”

Section: Discussionmentioning

confidence: 99%

Brain activity mediates the relation between emotional but not instrumental support and trait loneliness

et al. 2018

Social Cognitive and Affective Neuroscience

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Loneliness results from lacking satisfied social connections. However, little is known how trait loneliness, which is a stable personal characteristic, is influenced by different types of social support (i.e. emotional and instrumental support) through the brain activity associated with loneliness. To explore these questions, data of resting-state functional magnetic resonance imaging (R-fMRI) of 92 healthy participants were analyzed. We identified loneliness-related brain regions by correlating participants’ loneliness scores with amplitudes of low-frequency fluctuation (ALFF) of R-fMRI data. We then conducted mediation analyses to test whether the negative relation between each type of social support and loneliness was explained via the neural activity in the loneliness-related brain regions. The results showed that loneliness was positively related to the mean ALFF value within right inferior temporal gyrus (ITG). In addition, the negative relation between emotional support and loneliness was explained by a decrease in the spontaneous neural activity within right ITG but this pattern was not observed for instrumental support. These results suggest the importance of social information processing on trait loneliness and highlight the need to differentiate the functions of different types of social support on mental health from a neural perspective.

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Section: Discussionmentioning

confidence: 99%

Brain activity mediates the relation between emotional but not instrumental support and trait loneliness

et al. 2018

Social Cognitive and Affective Neuroscience

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“…Therefore, the evolutionary model predicts that loneliness activates conflicting motivations, a motivation to approach to repair or replace tattered bonds in the service of long-term self-preservation, and a motivation to withdraw from and be alert for potential social threats in the service of short-term self-preservation. Evidence that loneliness is related to hypervigilance for social threats has been provided by studies utilizing functional neuroimaging [29][30][31], electrical neuroimaging [25,26], eye tracking [32][33][34], and behavioral techniques [24].…”

Section: Introductionmentioning

confidence: 99%

Loneliness Predicts a Preference for Larger Interpersonal Distance within Intimate Space

Layden¹,

Cacioppo²,

Cacioppo³

2018

Preprint

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Loneliness is thought to serve as an adaptive signal indicating the need to repair or replace salutary social connections. Accordingly, loneliness may influence preferences for interpersonal distance. If loneliness simply motivates a desire to socially reconnect, then loneliness may be associated with a preference for smaller interpersonal distances. According to the evolutionary model of loneliness, however, loneliness also signals an inadequacy of mutual aid and protection, augmenting self-preservation motives. If loneliness both increases the motivation to reconnect and increases the motivation for self-protection, then the resulting approach-avoidance conflict should produce a preference for larger interpersonal distance, at least within intimate (i.e., proximal) space. Here, we report two survey-based studies of participants’ preferences for interpersonal distance to distinguish between these competing hypotheses. In Study 1 (N = 175), loneliness predicted preferences for larger interpersonal distance within intimate space net gender, objective social isolation, anxiety, depressive symptomatology, and marital status. In Study 2 (N = 405), we replicated these results, and mediation analyses indicated that measures of social closeness could not adequately explain our findings. These studies provide compelling evidence that loneliness predicts preferences for larger interpersonal distance within intimate space, consistent with predictions from the evolutionary model of loneliness.

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“…Interestingly, we observed a significant decrease of FC in the similar area of the vmPFC within both DMN and SN in the G-carrier group, leading us to speculate that −1019G allele is involved in affective processing through affecting resting-state network’s function. Furthermore, sgACC activity has been reported to be positively correlated with depressive symptoms 55 , and the FC between this area and the amygdala is positively correlated with harm avoidance score 56 . From a clinical perspective, the FC in the dorsal medial part of the PFC, a hub of the DMN, has been reported as a ‘hot wiring’ in major depressive patients when compared with healthy controls 12 .…”

Section: Discussionmentioning

confidence: 99%

Serotonin-1A receptor C-1019G polymorphism affects brain functional networks

Zheng

Onoda

Wada

et al. 2017

Sci Rep

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The serotonin-1A (5-HT1A) receptor is strongly implicated in major depression and other affective disorders due to its negative regulation of serotonin neurone firing rates. Behavioural and clinical studies have repeatedly reported that the −1019G allele carries a high susceptibility for affective disorders. However, the underlying pathophysiology remains unknown. Here, we employed a genetic neuroimaging strategy in 99 healthy human subjects to explore the effect of serotonin-1A receptor polymorphism on brain resting-state functional connectivity (FC). We used functional magnetic resonance imaging, along with a seed-based approach, to identify three main brain networks: the default mode network (DMN), the salience network (SN) and the central executive network. We observed a significant decrease in the FC of the DMN within the dorsolateral and ventromedial prefrontal cortices in G-carriers. Furthermore, compared with the C-homozygote group, we observed decreased FC of the SN within the ventromedial prefrontal cortex and subgenual anterior cingulate cortex in the G-carrier group. Our results indicate that 5-HT1A receptor genetic polymorphism modulates the activity of resting-state FC within brain networks including the DMN and SN. These genotype-related alterations in brain networks and FC may provide novel insights into the neural mechanism underlying the predisposition for affective disorders in G allele carriers.

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Functional Connectivity Density Mapping of Depressive Symptoms and Loneliness in Non-Demented Elderly Male

Cited by 33 publications

References 58 publications

Brain activity mediates the relation between emotional but not instrumental support and trait loneliness

Brain activity mediates the relation between emotional but not instrumental support and trait loneliness

Loneliness Predicts a Preference for Larger Interpersonal Distance within Intimate Space

Serotonin-1A receptor C-1019G polymorphism affects brain functional networks

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