Functional bioinspired nanocomposites for anticancer activity with generation of reactive oxygen species

Khalid, A. D.; -ur-Rehman, N.; Tariq, Ghulam Hasnain; Ullah, Sana; Buzdar, S. A.; Iqbal, Sadia Saghar; Sher, Emina Karahmet; Alsaiari, Norah Salem; Hickman, Graham J.; Sher, Farooq

doi:10.1016/j.chemosphere.2022.136885

Cited by 32 publications

(15 citation statements)

References 54 publications

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“…Another study utilizing the green method for the fabrication of silver-zinc oxide nanocomposite showed that the mean diameter was 62.5 nm and synthesized NCs have toxic effects against cancer cells [89]. According to researches, ZnO NPs' selective cell toxicity against cancerous cells can be the consequence of the pH-dependent dissolution of ZnO into Zn 2+ ions under an acidic intracellular environs, which can lead to oxidative stress due to generation of ROS [90][91][92][93]. ROS could also facilitate cell death using external apoptosis and necrosis [94].…”

Section: Cellular Toxicity Influence Of Prepared Npsmentioning

confidence: 99%

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Abad

Nadaf

Yazdi

2023

Micro & Nano Letters

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The zinc oxide‐silver oxide nanocomposite (ZnO.Ag2O3 particles) was prepared by using an aqueous plant extract of Haplophyllum obtusifolium for the first time. Powder X‐ray diffraction (PXRD), Fourier transforms spectroscopy (FTIR), field emission microscopy (FESEM), energy dispersive X‐ray analysis (EDX), and transmission electron microscopy (TEM) were applied to analyze the structure, functional groups, morphology, and purity of the prepared nanocomposite. PXRD revealed the formulation of ZnO.Ag2O3 for the particles. The investigation of functional groups has demonstrated the presence of some carbonated impurities along with absorbed water in the composition of the ZnO.Ag2O3 nanocomposite. Morphologically, particles have formed a petal‐like shape with different sizes. The EDX analysis also confirmed the composition of the prepared sample and the presence of 4.78% silver in the formula. Additionally, the TEM analysis revealed spherical and rectangular shapes with a particle size of 80.43 ± 46.73 nm. Moreover, the ZnO.Ag2O3 particles were used against cancer cells, which has shown synthesized NCs have a toxic effect against liver cancer cells in a concentration and time‐dependent manner.

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Section: Cellular Toxicity Influence Of Prepared Npsmentioning

confidence: 99%

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Abad

Nadaf

Yazdi

2023

Micro & Nano Letters

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“…Over the years of modern drug delivery, liposomes, micelles, dendrimers, and polymeric nanoparticles, inorganic nanoparticles as drug delivery vehicles have been exploited to improve the efficacy and therapeutic index concerning the PKPD of the drug, with the aim of reducing the off-target side effects and drug-related toxicity (Butreddy et al 2021 ; Khalid et al 2023 ). However, many hurdles still exist with these systems, including the specific organ targeting, the chemical and physical features related to toxicity, and the undesired immune response which ultimately obligates to discontinue the treatment in some individuals.…”

Section: Introductionmentioning

confidence: 99%

Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

et al. 2023

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Exosomes are nanosized (size ~ 30–150 nm) natural vesicular structures released from cells by physiological processes or pathological circumstances. Exosomes are growing in popularity as a result of their many benefits over conventional nanovehicles, including their ability to escape homing in the liver or metabolic destruction and their lack of undesired accumulation before reaching their intended targets. Various therapeutic molecules, including nucleic acids, have been incorporated into exosomes by different techniques, many of which have shown satisfactory performance in various diseases. Surface-modified exosomes are a potentially effective strategy, and it increases the circulation time and produces the specific drug target vehicle. In this comprehensive review, we describe composition exosomes biogenesis and the role of exosomes in intercellular signaling and cell–cell communications, immune responses, cellular homeostasis, autophagy, and infectious diseases. In addition, we discuss the role of exosomes as diagnostic markers, and their therapeutic and clinical implications. Furthermore, we addressed the challenges and outstanding developments in exosome research and discuss future perspectives. In addition to the current status of exosomes as a therapeutic carrier, the lacuna in the clinical development lifecycles along with the possible strategies to fill the lacuna have been addressed.

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“…Spinel nanoferrites have a ceramic material structure consisting of iron oxide and other metallic elements [2]. Spinel nanoferrites have a significant variety of usages, including switching and high-frequency devices [11], removal of organic industrial contaminants [16], hyperthermia treatments [17], high-performance energystorage equipment [10], drug delivery for cancer treatment [18], and waste-water management [19]. The spinel structure ferrites also have been used in lithium-ion batteries [20] in antimicrobial [21,22], and microwave applications [23,24].…”

Section: Introductionmentioning

confidence: 99%

Structural, dielectric, and thermal properties of Zn and Cr doped Mg- Co spinel nanoferrites

Hasanain

2023

Mater. Res. Express

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Nanoferrites play a pivotal role to resolve worldwide usage of electronic and microwave devices. Spinel ferrites have exceptional structural, morphological, and dielectric properties. The composition Zn0.5–xMg0.25+xCo0.25Cr1–xFe1+xO4 (ZMCCF) where x varies from 0-0.5 with the difference of 0.25 was synthesized via auto combustion (sol-gel) route. The structural, thermal, and dielectric characterizations were done to observe the responses of variation of x in designed nanoferrites. The designed nanoferrites with a variation of x experienced promising changes in structural, thermal, and dielectric responses. With the increase in frequency, the dielectric constant decrease which is the favorable trend of spinel ferrites based on Koop’s theory. This behavior is endorsed by the different cationic distributions in the spinel structure. The maximum value of the tangent loss at low frequencies reflects the application of these materials in medium frequency devices. Therefore planned spinel nanoferrites may beneficial for advanced electronics and microwave devices.

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Functional bioinspired nanocomposites for anticancer activity with generation of reactive oxygen species

Cited by 32 publications

References 54 publications

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

Structural, dielectric, and thermal properties of Zn and Cr doped Mg- Co spinel nanoferrites

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Functional bioinspired nanocomposites for anticancer activity with generation of reactive oxygen species

Cited by 32 publications

References 54 publications

Biosynthesis of ZnO.Ag2O3 using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Biosynthesis of ZnO.Ag2O3 using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

Structural, dielectric, and thermal properties of Zn and Cr doped Mg- Co spinel nanoferrites

Contact Info

Product

Resources

About

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells

Biosynthesis of ZnO.Ag₂O₃ using aqueous extract of Haplophyllum obtusifolium: Characterization and cell toxicity activity against liver carcinoma cells