Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature

Nicola, Maura Di; Barteselli, Giulio; Dell’Arti, Laura; Ratiglia, Roberto; Viola, Francesco

doi:10.1155/2015/249617

Cited by 51 publications

(60 citation statements)

References 45 publications

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“…The invisibility effect on the contour conditions of excess iron could be caused by the delayed effect where the excess iron accumulated in the organs and tissues of the body were not directly visible but were accumulative and could appear in the long term [15]. In coherence with literature, damage or deterioration of liver function are sometimes not visible on the morphological structure of the liver and could be observed on the histological structure of liver [16].…”

Section: Morphometry Of Liversupporting

confidence: 53%

The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

Safitri

Reniarti

Madihah

et al. 2017

KLS

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This research was carried out to detect the effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the liver structure of iron overload rat (Rattus norvegicus).The method of experimental used Completely Random Design (CRD in triple repetition. The treatment had been carried out orally. Iron dextran with total dose of 1.5 g kg −1 of body were given to rat on the first, fourth, seventh, ten and thirteenth day. Sappan Wood Extract (Caesalpinia sappan)200 mg kg −1 bw, 400 mg kg −1 bw, Wheat grass extract 100 mg kg −1 bw and Vitamin E 60 mg kg −1 bw were given to rat everyday for 15 days. At the seventeenth, rat were killed and their liver were taken. The observed parameters are morphological abnormality including the colour, the contour, ratio between liver weight and body weight as well as histological destruction. The result showed iron dextran treatment was proved the abnormality on morphological and histological desruction. Futhermore, Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment can decrease the morphological abnormality and the liver histological destructionon of iron overload rat.

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Section: Morphometry Of Liversupporting

confidence: 53%

The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

Safitri

Reniarti

Madihah

et al. 2017

KLS

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“…It has a systemic toxicity effect on the cardiovascular, respiratory, gastrointestinal, cutaneous, and nervous systems. Bone dysplasia and high-frequency sensory neuronal hearing loss have been reported 1 . As to ocular toxicity, desferrioxamine can cause nyctalopia, abnormal color perception, visual field defects, cataract formation, optic neuropathy, and pigmentary retinopathy.…”

Section: Discussionmentioning

confidence: 99%

“…Unfortunately, their use may lead to ocular toxicity, presenting in the form of a deterioration in visual acuity and color vision, night blindness, a scotoma or constricted visual field, retinopathy, optic neuropathy, and an abnormal retinal function detectable by electroretinogram (ERG). [1][2][3][4][5] Little information has been reported on the incidences of these ocular toxicities, and there are no standard eye-screening guidelines for patients.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Ocular Toxicity from Iron Chelating Agents at Siriraj Hospital

Thuangtong

2020

SMJ

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Objective: To determine the incidences of ocular toxicity and ocular findings, including structural and functional abnormalities, caused by iron chelating agents and detected by an electrophysiologic test at Siriraj Hospital. Methods: A retrospective chart review was conducted of patients receiving multiple blood transfusions and iron chelation therapy who had an eye examination at Siriraj Hospital between January 1995 and December 2017. Results: Ninety-seven charts were reviewed. The 88 patients included comprised 41 males and 47 females. Their ages ranged from 1 year 11 months to 47 years, with children predominant (mean: 8.13 years). Beta thalassemia HbE was the main diagnosis (87.5%). After receiving iron chelating agents, 3 patients had abnormal eye findings with suspected ocular toxicity. Two had retinal pigmentary changes, but only one of those two displayed a mildly decreased response in a scotopic electroretinogram. Although the third patient also showed a decreased electroretinogram response, there were no obvious retinal changes. All three received the iron chelating agents desferrioxamine, deferiprone, and/or deferasirox at different doses and for various durations. Conclusion: Although some pigmentary retinopathy and decreased electroretinogram responses were found, leading to ocular toxicity being suspected, there was a very low incidence of ocular toxicity from the chelating agents. In addition, the dosages of the agents causing ocular toxicity, and the duration of that toxicity, were inconclusive. Moreover, a gold standard for identifying ocular toxicity caused by chelating agents was not able to be established. Consequently, the risks and benefits of employing eye screening coupled with an invasive procedure like an electrophysiologic test will need to be weighed, especially with pediatric patients.

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“…DFO is most commonly administered as a slow subcutaneous infusion but can also be given intramuscularly or intravenously [49]. Ocular findings of DFO toxicity include cataract, optic neuropathy and retinopathy [50,51,52]. Retinal abnormalities include macular and peripheral pigmentary changes, retinal pigment epithelium degenerations and bull's eye maculopathy [53,54,55].…”

Section: Deferoxamine Retinopathymentioning

confidence: 99%

The Role of Multifocal Electroretinography in the Assessment of Drug-Induced Retinopathy: A Review of the Literature

Dettoraki

Moschos²

2016

Ophthalmic Res

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Multifocal electroretinography (mfERG) is an objective, noninvasive examination for the assessment of visual function. It enables the stimulation of multiple retinal areas simultaneously and recording of each response independently, providing a topographic measure of retinal electrophysiological activity in the central 40-50° of the retina. A clinical application of mfERG represents the assessment of retinal toxicity associated with systemic medications. Drug-induced retinopathy represents a disease that, although not common, requires early recognition: if not detected early, it may progress and cause irreversible retinal dysfunction with subsequent visual impairment. This review aims to evaluate the use of mfERG in the assessment of retinal dysfunction associated with various systemic pharmacological agents based on the currently available literature. The most commonly recognized systemic medications affecting retinal function are included, such as chloroquine and hydroxychloroquine, vigabatrin, deferoxamine, ethambutol, interferon-α, tamoxifen, digoxin, sildenafil, canthaxanthin, amiodarone and nefazodone. The role of mfERG in the early diagnosis of retinal toxicity and the evaluation of disease severity is reviewed, as well as its clinical value in monitoring disease progression or recovery after drug cessation.

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Functional and Structural Abnormalities in Deferoxamine Retinopathy: A Review of the Literature

Cited by 51 publications

References 45 publications

The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

The Effect of Sappan Wood Extract (Caesalpinia sappan), Wheat grass and Vitamin E Treatment on the Liver Structure of Iron overload of Rat (Rattus norvegicus)

Incidence of Ocular Toxicity from Iron Chelating Agents at Siriraj Hospital

The Role of Multifocal Electroretinography in the Assessment of Drug-Induced Retinopathy: A Review of the Literature

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