Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies

Kamle, Madhu; Mahato, Dipendra Kumar; Devi, Sushma; Lee, Jun Young; Kang, Sang Gu; Kumar, Pradeep

doi:10.3390/toxins11060328

Cited by 171 publications

(94 citation statements)

References 237 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, Fusarium verticillioides, Fusarium proliferatum, and other Fusarium spp. cause higher fumonisin contaminations with FB1 (Frisvad et al, 2007;Kamle et al, 2019). Co-occurrence of fumonisin producing Fusaria and black Aspergilli in the kernels of maize may influence the observed FB1/FB2 ratios (Logrieco et al, 2011;Susca et al, 2014).…”

Section: Fumonisinsmentioning

confidence: 99%

“…Fumonisins are among the most significant agricultural toxin. Although these mycotoxins are mainly produced by Fusarium species, like F. verticillioides and F. proliferatum, this paper focuses mostly on fumonisins produced by Aspergillus species (Kamle et al, 2019). Fumonisins can cause serious loss to agricultural production of cereals both in the field and during storage and can be dangerous to animals and humans as well (Mudili et al, 2014).…”

Section: Occurrence Of Aspergillus-derived Mycotoxins In the Feed Andmentioning

confidence: 99%

See 1 more Smart Citation

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

et al. 2020

View full text Add to dashboard Cite

Background: A atoxins are major contaminants of feed used in poultry industry that negatively affect animal and human health. In Ethiopia, previous studies on a atoxins mainly considered cattle feed and milk, but scarce information exists for poultry feeds. Method: The aim of this study was to determine the burden of a atoxin in poultry feed in bishoftu.Cross sectional study was conducted from December, 2018 to May, 2019and 33 compound poultry feed samples were randomly collected from chicken rearing villages of Bishoftuand analyzed for G2, G1, B2 , B1 and total a atoxins using HPLC. Results: The result indicated thatfrom a total of 33 samples 31(94%) samples were contaminated with a atoxin. The mean level of a atoxin G2, G1, B2, B1 and total a atoxinswere 18.00 µg/g, 88.5499 µg/g, 13.50µg/g, 70.11µg/g and 190.18µg/g respectively. This study curtained the level of a atoxinin 25 (72.75%) samples for AFT and 22 (66.67%) samples for AFB1 were above the limit of FDA regulatory levels of 20µg/g for poultry feed. Conclusion: The study showed the high contamination of a atoxins in poultry feed. The study warrants the need for preventive strategies of a atoxin contamination including implementation of regulatory legislation in poultry feeds in Bishoftu.

show abstract

Section: Fumonisinsmentioning

confidence: 99%

Section: Occurrence Of Aspergillus-derived Mycotoxins In the Feed Andmentioning

confidence: 99%

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Their highest amounts are found in maize and maize-based products. Health issues linked to FBs are cancer of the esophagus, hepatocarcinoma, the stimulation and suppression of the immune system, and defects in the neural tube [47]. MLs set for the sum of FBs set in EU are from 200 to 1000 µg/kg for different kinds of maize-based products [33].…”

Section: Fumonisinsmentioning

confidence: 99%

Stability of Mycotoxins in Individual Stock and Multi-Analyte Standard Solutions

Kiseleva¹,

Chalyy²,

Седова³

et al. 2020

Toxins

View full text Add to dashboard Cite

Standard solutions of mycotoxins prepared in RP HPLC solvents from neat standards are usually used for analytical method development. Multi-mycotoxin HPLC-MS/MS methods necessitate stability estimation for the wide spectrum of fungal metabolites. The stability of individual diluted stock standard solutions of mycotoxins in RP-HPLC solvents and multi-analyte HPLC-MS/MS calibrants was evaluated under standard storage and analysis conditions. Individual stock standard solutions of aflatoxins, sterigmatocystin, A-and B-trichothecenes, zearalenone and its analogues, ochratoxin A, fumonisins, Alternaria toxins, enniatins and beauvericin, moniliformin, citrinin, mycophenolic, cyclopiazonic acids and citreoviridin were prepared in RP-HPLC solvents and stored at −18 • C for 14 months. UV-spectroscopy was utilized to monitor the stability of analytes, excluding fumonisins. The gradual degradation of α-, β-zearalenol and α-, β-zearalanol in acetonitrile was detected. Aflatoxins and sterigmatocystin, zearalenone, Alternaria toxins, enniatins and beauvericin, citrinin, mycophenolic, cyclopiazonic acids and citreoviridin can be referred to as stable. The concentration of the majority of trichothecenes should be monitored. Diluted multi-mycotoxin standard in water/methanol (50/50 v/v) solutions acidified with 0.1% formic acid proved to be stable in silanized glass at 23 • C exposed to light for at least 75 h (CV ≤ 10%). An unexpected manifestation of MS/MS signal suppression/enhancement was discovered in the course of multi-mycotoxin standard solution stability evaluation. Key Contribution:The stability of the wide spectrum of mycotoxins in individual standard solutions in RP-HPLC solvents and multi-analyte HPLC-MS/MS calibrants under standard storage and analysis conditions is discussed basing on experimental and literature data.

show abstract

“…Fumonisins of group B have been widely studied due to their prevalence and toxicological effects. In particular, fumonisin B 1 (FB 1 ) is related to chronic effects in human health, e.g., hepatocarcinoma, nephrotoxicity, suppression of the immune system and defects in the neural-tubes [24]. In addition, this mycotoxin has been classified by the IARC as a group 2B (possible carcinogen for humans) [25].…”

Section: Introductionmentioning

confidence: 99%

Potential Application of Lactic Acid Bacteria to Reduce Aflatoxin B1 and Fumonisin B1 Occurrence on Corn Kernels and Corn Ears

Nazareth

Luz

Torrijos

et al. 2019

Toxins

View full text Add to dashboard Cite

Fungal spoilage is an important issue for the food industry, leading to food sensory defects, food waste, economic losses and public health concern through the production of mycotoxins. Concomitantly, the search for safer natural products has gained importance since consumers began to look for less processed and chemically treated foods. In this context, the aim of this study was to evaluate the antifungal and antimycotoxigenic effect of seven strains of Lactobacillus plantarum. Lactic acid bacteria (LAB) were grown on Man Rogosa Sharpe (MRS) broth at 37 °C in anaerobic conditions. After that, the cell-free supernatant (CFS) were recovered to determine its antifungal activity by halo diffusion agar test. In addition, minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) was determined for each L. plantarum CFS by 96-well microplates method. Additionally, CFS was used as a natural biocontrol agent on corn kernels and corn ears contaminated with Aspergillus flavus and Fusarium verticillioides, respectively. The L. plantarum CECT 749 CFS showed the highest antifungal effect against all essayed strains. Moreover, the employment of this CFS in food reduced the mycotoxin production at a percentage ranging from 73.7 to 99.7%. These results suggest that the L. plantarum CECT 749 CFS could be promising for the biocontrol of corn.

show abstract

Fumonisins: Impact on Agriculture, Food, and Human Health and their Management Strategies

Cited by 171 publications

References 237 publications

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

Toxicological and Medical Aspects of Aspergillus-Derived Mycotoxins Entering the Feed and Food Chain

Stability of Mycotoxins in Individual Stock and Multi-Analyte Standard Solutions

Potential Application of Lactic Acid Bacteria to Reduce Aflatoxin B1 and Fumonisin B1 Occurrence on Corn Kernels and Corn Ears

Contact Info

Product

Resources

About