Fumiquinazolines A–G, novel metabolites of a fungus separated from a Pseudolabrus marine fish

Identification of a quinazoline alkaloid produced byPenicillium vinaceum, an endophytic fungus fromCrocus sativus

“…To the best of our knowledge, this is the first time that compound 1 has been found in plant endophytes, although fungi belonging to the genera Penicillium serve as a rich source of alkaloids clearly derived from amino acids (Hart & Magomedov, 2001). These quinazoline alkaloids have been reported to show moderate cytotoxicities in vitro (Takahashi et al, 1995).…”

Biological Activities of the Alkaloid Quinazoline Extracted from Aspergillus nomius

“…Species of the genus Aspergillus aer known to produce alkaloids with pyrazino[2,1-b]quinazoline-3,6-dione system. Among them glyantrypine was isolated from A. clavatus (Penn et al, 1992), fumiquinazolines A-G from A. fumigatus (Takahashi et al, 1995). Two new alkaloids carnequinazolines were determined as quinazolinone with additional oxidation and alkylation patterns in their molecules were isolated from A. carneus KMM 4638, obtained from the marine brown alga Laminaria sachalinensis (Zhuravleva et al, 2012).…”

Recent progress in the synthesis of heterocyclic natural products by the Staudinger/intramolecular aza-Wittig reaction

“…Snider has utilized the quinazolinone annelation method (see section 2.2) for the first synthesis of (+)-fumiquinazoline G 36b (the natural product is the (-)-enantiomer; a 3:2 equilibrium mixture is obtained with base from either fumiquinazoline F or G 29 )…”