Biological Activities of the Alkaloid Quinazoline Extracted from  Aspergillus nomius

Ali, Mohamed I.; Abdelfattah, Ahmed; Khalil, Neveen M.; Sayed, Mohamed

doi:10.21608/ejbo.2017.1079.1096

Cited by 3 publications

(5 citation statements)

References 23 publications

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“…nomius with antioxidant and anti-tumor activity (Ali et al 2017). Also, A. fumigatus isolate R7 exhibited high antimicrobial activity (Shaaban et al 2013).…”

Section: Aspergillus In Egyptmentioning

confidence: 99%

The Egyptian Ascomycota 1: Genus Aspergillus

Abdel-Azeem

Abu-Elsaoud

Darwish

et al. 2020

MBJ

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Since Pier Antonio Micheli described and published genus Aspergillus in Nova Plantarum Genera in 1729 the genus attracted an immense interest. The published Egyptian literature on the genus is scattered and fragmentary. By screening the available sources of information since 1921, it was possible to figure out a range of 150 taxa that could be representing genus Aspergillus in Egypt up to the present time. Ten species of Aspergillus were introduced as type materials from Egypt since 1964 till now. Recorded taxa were assigned to 5 subgenera and 25 sections. This article includes Aspergillus species that are known to Egypt, provides a comprehensive checklist of species isolated from Egypt and provisional key to the identification of reported taxa is given. Although the present study will add some new data to our information concerning the Ascomycota of Egypt, this work must be considered as a provisional one always waiting for continuous supplementation.

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“…nomius with antioxidant and anti-tumor activity (Ali et al 2017). Also, A. fumigatus isolate R7 exhibited high antimicrobial activity (Shaaban et al 2013).…”

Section: Aspergillus In Egyptmentioning

confidence: 99%

The Egyptian Ascomycota 1: Genus Aspergillus

Abdel-Azeem

Abu-Elsaoud

Darwish

et al. 2020

MBJ

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“…Twenty-four articles analyzed species of the genus Aspergillus, of which eight articles tested functional extracts on CRC cell lines. Ethyl acetate extracts (five articles) showed IC 50 values between 42.75 and 185.9 μg/mL [ 33 , 36 , 58 ]. Moreover, Ali et al [ 36 ] reported that ethyl acetate extracts from nine different Aspergillus species induced death of 50.1 to 69.1% of HCT-116 cells.…”

Section: Resultsmentioning

confidence: 99%

“…Ethyl acetate extracts (five articles) showed IC 50 values between 42.75 and 185.9 μg/mL [ 33 , 36 , 58 ]. Moreover, Ali et al [ 36 ] reported that ethyl acetate extracts from nine different Aspergillus species induced death of 50.1 to 69.1% of HCT-116 cells. A similar extract obtained by Artasasta et al [ 33 ] was reported to cause a significant reduction in the viability of WiDr cells.…”

Section: Resultsmentioning

confidence: 99%

“…Functional extract fractions (three articles) were tested on the HCT-116 cell line, with IC 50 values between 5.28–193.64 µg/mL [ 24 , 33 ] and 15.8–88% cytotoxicity [ 19 ]. Interestingly, most of the extracts obtained from the genus Aspergillus were also tested on other cancer cell lines of liver, larynx, cervix, and breast [ 23 , 32 , 36 , 58 ], in which, in general, a higher cytotoxic effect was noted compared to CRC cells. Only the functional extracts obtained by Ashour et al [ 24 ] reduced the IC 50 to a greater extent in CRC (more than half the IC 50 ) than in other tumor cells, such as those derived from liver and breast cancer.…”

Section: Resultsmentioning

confidence: 99%

“…An aqueous extract and an organic residue obtained with dichloromethane were tested in HCT-116 cells, obtaining IC 50 values between 12 and 100 μg/mL, respectively [ 66 ]. In addition, the genera Bipolaris, Phoma, Drechslera, and Curvularia were studied by obtaining functional extracts, which evidenced IC 50 values ranging from 18.97 to 202.5 µg/mL against HCT-116, HT-29, and HCT-8 cells, with similar antiproliferative activity in breast cancer cell lines [ 23 , 36 , 70 ]. From the Drechslera genus, di-2-ethylhexyl phthalate was isolated (IC 50 9.5 ± 0.4 µg/mL in HCT-116 cell line).…”

Section: Resultsmentioning

confidence: 99%

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In Vitro Efficacy of Extracts and Isolated Bioactive Compounds from Ascomycota Fungi in the Treatment of Colorectal Cancer: A Systematic Review

et al. 2022

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Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. Despite the advances and success of current treatments (e.g., chemotherapy), there are multiple serious side effects which require the development of new treatment strategies. In recent years, fungi have gained considerable attention as a source of extracts and bioactive compounds with antitumor capabilities because of their antimicrobial and antioxidant properties and even their anti-inflammatory and antiviral activities. In the present review, a systematic search of the existing literature in four electronic databases was carried out in which the antitumor activity against CRC cells of Ascomycota fungi extracts or compounds was tested. The systematical research in the four databases resulted in a total of 883 articles. After applying exclusion and inclusion criteria, a total of 75 articles were finally studied. The order Eurotiales was the most studied (46% of the articles), and the ethyl acetate extraction was the most used method (49% of the papers). Penicillium extracts and gliotoxin and acetylgliotoxin G bioactive compounds showed the highest cytotoxic activity. This review also focuses on the action mechanisms of the extracts and bioactive compounds of fungi against CRC, which were mediated by apoptosis induction and the arrest of the cell cycle, which induces a notable reduction in the CRC cell proliferation capacity, and by the reduction in cell migration that limits their ability to produce metastasis. Thus, the ability of fungi to induce the death of cancer cells through different mechanisms may be the basis for the development of new therapies that improve the current results, especially in the more advanced stages of the CCR.

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