Exploitation of Aspergillus flavus synthesized copper oxide nanoparticles as a novel medical agent

Amin, Mohamed A.; Elaasser, Mahmoud M.; Ayoub, S. M.; Shiekh, H. H. El; Sakr, Tamer M.

doi:10.1007/s10967-021-07637-8

Cited by 3 publications

(3 citation statements)

References 64 publications

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“…The high target/nontarget ratio, which was 9 after 2 h post-injection, is a benefit of the suggested radiolabeled nano-system ( 99m Tc- NGO-COOH). The greatest T/NT ratio for previously published radiolabeled nano-systems was 3.7 ± 0.45–7 ± 0.5 [ 15 , 74 , 75 ]. While NGO T/NT ratio was 2 ± 0.5 as reported [ 76 ].…”

Section: Resultsmentioning

confidence: 99%

Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation

Sakr,

Elsabagh,

Fayez

et al. 2023

DARU J Pharm Sci

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Background In this study, a combination of nanotechnology, organic synthesis and radiochemistry were utilized in order to design an efficient nano-system conjugated with a suitable radionuclide and an antitumor agent for possible application as tumor theragnostic agent. Method Four novel compounds (3 and 4a-c) bearing tetrahydroquinazoline-7-sulfonohydrazide or 1,2,3,4-tetrahydroquinazoline-7-sulfonamide scaffold were designed. Then, docking study predicted that the compounds can be considered as potential inhibitors for PARP-1. Following that; the four compounds were synthesized and properly characterized using 1HNMR, 13CNMR, IR and Mass spectroscopy. The cytotoxic effect of the four compounds was evaluated against breast cancer cell line (MDA-MB-436), where compound 3 showed the most promising cytotoxic effect. The inhibitory effect of the four compounds was evaluated in vitro against PARP-1. Result Carboxylated graphene oxide nanosheets (NGO-COOH) were synthesized by a modified Hummer's method and has size of range 40 nm. The NGO-COOH nanosheets were proven to be safe and biocompatible when tested in vitro against normal human lung fibroblast cells (MRC-5). The prepared NGO-COOH nanosheets were conjugated with compound 3 then radiolabeled with 99mTc to yield 99mTc-NGO-COOH-3 with a radiochemical yield of 98.5.0 ± 0.5%. 99mTc-NGO-COOH-3 was injected intravenously in solid tumor bearing mice to study the degree of localization of the nano-system at tumor tissue. The results of the study revealed, excellent localization and retention of the designed nano-system at tumor tissues with targeting ratio of 9.0. Conclusion Stirred a new candidate tumor theragnostic agent that is safe, selective and stable. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation

Sakr,

Elsabagh,

Fayez

et al. 2023

DARU J Pharm Sci

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“…In recent years, the fungi-mediated synthesis of copper oxide NPs has become of interest (Table 1). CuO nanospheres (average size 32.4 nm) with high antimicrobial and antitumor activities were obtained with Aspergillus flavus culture liquid [27]. CuO NPs synthesized with Aspergillus terreus culture liquid showed anticancer activity in a concentration-dependent manner [30].…”

Section: Myco-synthesis Of Copper Oxide Nanoparticlesmentioning

confidence: 99%

Diversity of Mycogenic Oxide and Chalcogenide Nanoparticles: A Review

2023

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Oxide and chalcogenide nanoparticles have great potential for use in biomedicine, engineering, agriculture, environmental protection, and other research fields. The myco-synthesis of nanoparticles with fungal cultures, their metabolites, culture liquids, and mycelial and fruit body extracts is simple, cheap and environmentally friendly. The characteristics of nanoparticles, including their size, shape, homogeneity, stability, physical properties and biological activity, can be tuned by changing the myco-synthesis conditions. This review summarizes the data on the diversity of oxide and chalcogenide nanoparticles produced by various fungal species under different experimental conditions.

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“…In this review, we present inorganic NPs that are synthesized using reducing and stabilizing agents where the reducing agent is responsible for the reduction of the metal from high oxidation states (+3, +2 or +1) to its metallic form (zero oxidation state), while the stabilizing agent is responsible for surface stabilization of metal nano materials [ 22 , 42 , 44 , 45 , 47 , 49 , 50 , 52 ]. Various NPs including AuNPs, selenium nanoparticles (SeNP), iron nanoparticles (FeNP), copper nanoparticles (CuNP) and silver nanoparticles (AgNP) were evaluated for their effective delivery of different radionuclides such as tecnetium-99m (Tc-99m), iodine-131 (I-131) and gold-198 (Au-198) to tumor sites for tumor theranostics [ 42 , 44 , 45 , 47 , 48 , 49 , 50 , 51 , 52 , 72 ].…”

Section: Design and Development Of Nanoparticlesmentioning

confidence: 99%

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

et al. 2022

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The rapidly growing interest in the application of nanoscience in the future design of radiopharmaceuticals and the development of nanosized radiopharmaceuticals in the late 2000′s, resulted in the creation of a Coordinated Research Project (CRP) by the International Atomic Energy Agency (IAEA) in 2014. This CRP entitled ‘Nanosized delivery systems for radiopharmaceuticals’ involved a team of expert scientist from various member states. This team of scientists worked on a number of cutting-edge areas of nanoscience with a focus on developing well-defined, highly effective and site-specific delivery systems of radiopharmaceuticals. Specifically, focus areas of various teams of scientists comprised of the development of nanoparticles (NPs) based on metals, polymers, and gels, and their conjugation/encapsulation or decoration with various tumor avid ligands such as peptides, folates, and small molecule phytochemicals. The research and development efforts also comprised of developing optimum radiolabeling methods of various nano vectors using diagnostic and therapeutic radionuclides including Tc-99m, Ga-68, Lu-177 and Au-198. Concerted efforts of teams of scientists within this CRP has resulted in the development of various protocols and guidelines on delivery systems of nanoradiopharmaceuticals, training of numerous graduate students/post-doctoral fellows and publications in peer reviewed journals while establishing numerous productive scientific networks in various participating member states. Some of the innovative nanoconstructs were chosen for further preclinical applications—all aimed at ultimate clinical translation for treating human cancer patients. This review article summarizes outcomes of this major international scientific endeavor.

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Exploitation of Aspergillus flavus synthesized copper oxide nanoparticles as a novel medical agent

Cited by 3 publications

References 64 publications

Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation

Multi-functionalization of reduced graphene oxide nanosheets for tumor theragnosis: Synthesis, characterization, enzyme assay, in-silico study, radiolabeling and in vivo targeting evaluation

Diversity of Mycogenic Oxide and Chalcogenide Nanoparticles: A Review

IAEA Contribution to Nanosized Targeted Radiopharmaceuticals for Drug Delivery

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