Full Regeneration of Maxillary Alveolar Bone Using Autogenous Partially Demineralized Dentin Matrix and Particulate Cancellous Bone and Marrow for Implant-Supported Full Arch Rehabilitation

Abstract

Autogenous partially demineralized dentin matrix (APDDM) has been reportedly used as a superior bone graft material. A 52-year-old Japanese man who exhibited severe periodontitis was referred for oral rehabilitation. He underwent wide-range anterior maxillary alveolar bone and bilateral sinus floor augmentation by grafting of a mixture of APDDM and particulate cancellous bone and marrow (PCBM); subsequently, he underwent implant-supported full arch rehabilitation. He has been followed up for 4 years after placement of the final restoration without any complications, and his physiological bone volume has been maintained. APDDM constitutes an alternative treatment that may increase the volume of graft material and might prevent rapid resorption of PCBM, because APDDM served as a scaffold for osteoblasts from PCBM. When possible, it may be useful to apply APDDM as a graft material with PCBM for large-volume alveolar bone regeneration.

Autogenous Dentin Particulate Graft for Alveolar Ridge Augmentation with and without Use of Collagen Membrane: Preliminary Histological Analysis on Humans

“…Extracted teeth have long been considered waste materials. However, dentin is chemically and physically very similar to bone, with the only difference being that the latter is less mineralized [26]. The purpose of this case series was to define the differences between the use of an autogenous dentin particulate graft with and without collagen membrane after alveolar ridge augmentation procedures from a histomorphometric point of view (Figure 5).…”

Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review

“…In large bone defects, there is the problem of the amount of grafting that is needed in these cases. Umebayashi et al have suggested the use of autologous bone when the quantity of teeth is limited, which can also be mixed with other biomaterials [ 133 ]. The matrix of the autologous tooth was partially demineralized (APDDM) and used in combination with particulate cancellous and medullary bone (PCBM) in bilateral sinus lift and in anterior maxillary reconstruction.…”

“…This combination showed the osteoinductive capacities of PBCM and the osteoconductivity of APDDM. The implant was performed after 3.5 months [ 133 ]. Another suggested combination was that with xenographic material (Bio-Oss), which gave positive results in bone regeneration, but compared with the dental matrix alone, this last one forms a greater amount of bone [ 134 ].…”

“…Another suggested combination was that with xenographic material (Bio-Oss), which gave positive results in bone regeneration, but compared with the dental matrix alone, this last one forms a greater amount of bone [ 134 ]. In any case, the dental matrix can be combined with other biomaterials in large bone defects, which provides very positive results [ 133 , 134 , 135 , 136 ]. From the physio-chemical side, the tooth can be considered a material similar to bone but with a higher mineralization.…”

Histological Evidences of Autograft of Dentin/Cementum Granules into Unhealed Socket at 5 Months after Tooth Extraction for Implant Placement

“…Demineralized dentin/cementum matrix (DDM) is a decellularized matrix prepared through demineralization (<pH 1.0), washing by saline or distilled water, and/or freeze-drying [ 3 ]. Recently, many autograft cases were reported from the world [ 4 , 5 , 6 , 7 , 8 , 9 ]. Additionally, familial grafts between a parent and a child were successfully achieved, and the first successful procedure occurred in South Korea [ 10 ].…”