Frontal Fibrosing Alopecia: To Treat or Not to Treat?

Rallis, Eustathios; Gregoriou, Stamatis; Christofidou, Eleftheria; Rigopoulos, Dimitrios

doi:10.2310/7750.2010.09041

Cited by 32 publications

(32 citation statements)

References 31 publications

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“…Une composante génétique reste à confirmer après l'identification récente de cas familiaux comme dans notre première observation. En matière du traitement, aucun n'a fait la preuve de son efficacité [19]. La corticothérapie intra-lésionnelle permet d'obtenir une amélioration chez presque 60 % des patients [20].…”

Section: Discussionunclassified

Alopécie frontale fibrosante : à propos de trois cas pédiatriques

Atarguine

Hocar

Hamdaoui³

et al. 2016

Archives de Pédiatrie

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Section: Discussionunclassified

Alopécie frontale fibrosante : à propos de trois cas pédiatriques

Atarguine

Hocar

Hamdaoui³

et al. 2016

Archives de Pédiatrie

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“…Other medications and medication combinations may be tried such as hydroxychloroquine, topical calcineurin inhibitors, or minoxidil; however, each has inconsistent results (MacDonald et al, 2012). In patients also presenting with androgenic alopecia in one study, finasteride with minoxidil was attempted with no significant improvement (Rallis, Gregoriou, Christofidou, & Rigopoulos, 2010). However, a systematic review found that oral 5-alpha reductase inhibitors had a good clinical response in 45% of patients and were the most effective treatment (Rácz, Gho, Moorman, Noordhoek Hegt, & Neumann, 2013).…”

Section: Treatment Optionsmentioning

confidence: 93%

Frontal Fibrosing Alopecia

Kimes

Carlson

2015

Journal of the Dermatology Nurses' Association

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Frontal fibrosing alopecia (FFA) is a form of hair loss with an unknown etiology seen in postmenopausal women. Its clinical presentation is characterized by alopecia along the frontal hairline that extends posteriorly with scarring. On examination, perifollicular hyperkeratosis and erythema may be present. Histologically, FFA is identical to lichen planopilaris. Unfortunately, there is no consistently effective treatment. Various treatment options may be tried, and eventually, patients may opt to use camouflage such as wigs to disguise the alopecia. In time, most cases will stabilize, with or without treatment. More research is needed not only to determine etiology but also to establish evidencebased treatment options for FFA.

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“…Postmenopausal FFA is a distinct cicatricial alopecia [34–36]. It corresponds to a progressive condition responsible for the destruction of the upper portion of the hair follicle by a lymphoid cell infiltrate.…”

Section: Climacteric Hair Lossmentioning

confidence: 99%

“…It corresponds to a progressive condition responsible for the destruction of the upper portion of the hair follicle by a lymphoid cell infiltrate. This process induces a distinctive pattern of hair rarefaction corresponding to a symmetrical regression of the frontal and temporal hairline, combined with partial to complete loss of the eyebrows [34–36]. The hair loss onset is particularly difficult to identify as patients present relatively late during the disease progression.…”

Section: Climacteric Hair Lossmentioning

confidence: 99%

Alterations in Hair Follicle Dynamics in Women

Piérard-Franchimont

Pierard

2013

BioMed Research International

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Endocrine changes supervening after parturition and menopause participate in the control of sebum production and hair growth modulation. The ensuing conditions include some peculiar aspects of hair loss (effluvium), alopecia, and facial hirsutism. The hair cycling is of major clinical relevance because most hair growth disorders result from disturbances in this chronobiological feature. Of note, any correlation between a biologic abnormality and hair cycling disturbance does not prove a relationship of causality. The proportion of postmenopausal women is rising in the overall population. Therefore, the prevalence of these hair follicle disturbances is globally on the rise. Current therapies aim at correcting the underlying hormonal imbalances, and at improving the overall cosmetic appearance. However, in absence of pathogenic diagnosis and causality criteria, chances are low that a treatment given by the whims of fate will adequately control hair effluvium. The risk and frequency of therapeutic inertia are further increased. When the hair loss is not controlled and/or compensated by growth of new hairs, several clinical aspects of alopecia inexorably develop. Currently, there is little evidence supporting any specific treatment for these endocrine hair disorders in post-partum and postmenopausal women. Current hair treatment strategies are symptomatic and nonspecific so current researchers aim at developing new, targeted methods.

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Frontal Fibrosing Alopecia: To Treat or Not to Treat?

Cited by 32 publications

References 31 publications

Alopécie frontale fibrosante : à propos de trois cas pédiatriques

Alopécie frontale fibrosante : à propos de trois cas pédiatriques

Frontal Fibrosing Alopecia

Alterations in Hair Follicle Dynamics in Women

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