Dovitinib (TKI258) is a multi-targeted receptor tyrosine kinase inhibitor currently under clinical trials for a wide variety of cancers. Well-known side effects include nausea, vomiting, diarrhea, and fatigue. To date, there have only been only two reported cases with skin manifestations as a side effect. We report a case of eruptive facial milia and comedones in the setting of dovitinib treatment for metastatic gastrointestinal cancer. This case is unique as the clinical presentation was more rapid in onset and showed an absence of inflammatory lesions. Although the pathogenesis for skin manifestations is presently unknown, we present this case to increase awareness of potentially under-reported cutaneous side effects.The opinions or assertions contained herein are the private views of the authors and not to be construed as official or as reflecting the views of the U.S. Army or the Department of Defense.
Neurofibromatosis type 1 is a genetic disorder characterized by variable phenotypic manifestations. The diagnostic criteria, established in 1987, are broad to encompass these pleiotropic findings. Included are the specific osseous manifestations of sphenoid dysplasia and dysplasia or thinning of the cortex of long bones. This review highlights recent evidence on the role of neurofibromin in bone development and suggests consideration for additional diagnostic criteria.
Frontal fibrosing alopecia (FFA) is a form of hair loss with an unknown etiology seen in postmenopausal women. Its clinical presentation is characterized by alopecia along the frontal hairline that extends posteriorly with scarring. On examination, perifollicular hyperkeratosis and erythema may be present. Histologically, FFA is identical to lichen planopilaris. Unfortunately, there is no consistently effective treatment. Various treatment options may be tried, and eventually, patients may opt to use camouflage such as wigs to disguise the alopecia. In time, most cases will stabilize, with or without treatment. More research is needed not only to determine etiology but also to establish evidencebased treatment options for FFA.
Up to 1.3 million children from the former Soviet Union (fSU) andEastern Europe have been placed in institutional care worldwide.With the hope of ensuring the child's health in the immediate postadoption period, these children are known to receive many injections of vaccines, vitamins, and medications, many unnecessary and often administered with unsafe technique. This practice can lead to formation of suppurative granulomas in these children. Though rare, dermatologists should be aware of these conditions in adoptees from Eastern Europe.hosts. 5 Although we were unable to confirm that the lesions were caused by atypical mycobacteria, the epidemiology, histology, and rapid response to antimycobacterial agents suggest this is the case.Though rare, dermatologists should be aware of skin conditions in international adoptees, 2 including those associated with multiple injections prior to adoption.
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