From dermal exposure to internal dose

Sandt, J.J.M. van de; Dellarco, Mike; Hemmen, J.J. van

doi:10.1038/sj.jes.7500579

Cited by 20 publications

(15 citation statements)

References 25 publications

(24 reference statements)

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“…The internal dose was estimated by combining the ADE with data on the dermal absorption rate ( Van de Sandt et al, 2007). Accordingly, we adopted the following equations (Ross et al, 2008).…”

Section: Calculation Methodsmentioning

confidence: 99%

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Exposure and health risk assessment of applicators to DDT during indoor residual spraying in malaria vector control program

Wassie

Spanoghe

Tessema

et al. 2012

J Expo Sci Environ Epidemiol

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We assessed exposure of applicators, health risk of DDT to the applicators and evaluated the applicability of existing pesticide exposure models for Indoor Residual Spraying (IRS). Patch sampling for dermal and personal air sampler for inhalation exposure were used in monitoring 57 applicators on the exposure assessment to DDT. The exposure of the applicators was also estimated using three exposure models. The mean actual dermal exposure was 449 mg total DDT per applicator per one house treatment. The applicators were exposed to DDT much beyond the

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Section: Calculation Methodsmentioning

confidence: 99%

“…Therefore, the derived AOEL of DDT is 0.01mg/kg bw/day. In EU, the dermal risk assessment approach is also based on the use of NOAEL from an oral dosing toxicity study in animals ( Van de Sandt, 2007).…”

Section: In Deriving Aoel It Is Recommended To Use the Adverse Effecmentioning

confidence: 99%

Exposure and health risk assessment of applicators to DDT during indoor residual spraying in malaria vector control program

Wassie

Spanoghe

Tessema

et al. 2012

J Expo Sci Environ Epidemiol

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“…Skin contact with hazardous chemicals is an important exposure route for certain occupational groups (Franklin, 1984;Lees et al, 1987;Fenske, 1993;Van de Sandt et al, 2007), leading to the development of new quantitative methods (Fenske et al, 1986;Roff, 1997). Dermal contact and absorption can also be important in residential settings (McKone, 1989;Shatkin and Brown, 1991;Zartarian et al, 2000), but proper estimates of exposures and doses are still lacking (Kissel, 2010).…”

Section: Dermal Exposurementioning

confidence: 99%

For good measure: Origins and prospects of exposure science (2007 Wesolowski Award Lecture)

Fenske

2010

J Expo Sci Environ Epidemiol

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Measurement is the foundation of exposure science. Associations between illness and environmental agents have been observed for millennia, but the ability to quantify exposure and dose has been possible only in the last century. Improved means of measurement and refined concepts of who, what, when, where, and why to measure have been the seminal contributions of exposure science to the study of disease causation and prevention. This paper examines critical advancements in exposure assessment associated with workplace health and safety, and the groundbreaking work of the US Public Health Service. Many of the key concepts of modern exposure science have their origin in these early studies. Occupational hygiene scientists have conducted receptor-based exposure analyses for more than 80 years, evaluating indoor air, defining microenvironments, and developing personal sampling techniques. Biological monitoring of community populations including children, dermal exposure monitoring, duplicate diet studies, and multipathway, aggregate exposure assessments can be traced to early public health studies. As we look to the future, we see that new technologies and techniques are expanding the scope of exposure science dramatically. We need to ensure that the highest of scientific standards are maintained, make a greater effort to include occupational hygiene scientists, microbiologists, and behavioral scientists in the field, and promote new sources of training and research support. Exposure science has a critical role to play in the prevention strategy that is central to public health.

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“…The potential risk for exposure to toxic agents and the resulting toxicity can be determined by monitoring for the presence of toxic agents either in the environment or the workplace (external dose) or in the target organs/tissues (internal dose) of the exposed population (Simmons et al, 2005;Van de Sandt et al, 2007). Several biomarkers indicative of the interaction between a toxic agent and its respective target organ have been developed to determine the toxicity resulting from exposure to the toxic agent (Lacour et al, 2005;Rockett & Kim, 2005;Thukral et al, 2005;Wallace et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Blood transcriptomics: applications in toxicology

Joseph

Umbright

Sellamuthu

2013

J of Applied Toxicology

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The number of new chemicals that are being synthesized each year has been steadily increasing. While chemicals are of immense benefit to mankind, many of them have a significant negative impact, primarily owing to their inherent chemistry and toxicity, on the environment as well as human health. In addition to chemical exposures, human exposures to numerous non-chemical toxic agents take place in the environment and workplace. Given that human exposure to toxic agents is often unavoidable and many of these agents are found to have detrimental human health effects, it is important to develop strategies to prevent the adverse health effects associated with toxic exposures. Early detection of adverse health effects as well as a clear understanding of the mechanisms, especially at the molecular level, underlying these effects are key elements in preventing the adverse health effects associated with human exposure to toxic agents. Recent developments in genomics, especially transcriptomics, have prompted investigations into this important area of toxicology. Previous studies conducted in our laboratory and elsewhere have demonstrated the potential application of blood gene expression profiling as a sensitive, mechanistically relevant and practical surrogate approach for the early detection of adverse health effects associated with exposure to toxic agents. The advantages of blood gene expression profiling as a surrogate approach to detect early target organ toxicity and the molecular mechanisms underlying the toxicity are illustrated and discussed using recent studies on hepatotoxicity and pulmonary toxicity. Furthermore, the important challenges this emerging field in toxicology faces are presented in this review article.

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From dermal exposure to internal dose

Cited by 20 publications

References 25 publications

Exposure and health risk assessment of applicators to DDT during indoor residual spraying in malaria vector control program

Exposure and health risk assessment of applicators to DDT during indoor residual spraying in malaria vector control program

For good measure: Origins and prospects of exposure science (2007 Wesolowski Award Lecture)

Blood transcriptomics: applications in toxicology

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