BackgroundIndoor Residual Spraying (IRS), insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are key components in malaria prevention and control strategy. However, the development of resistance by mosquitoes to insecticides recommended for IRS and/or ITNs/LLINs would affect insecticide-based malaria vector control. We assessed the susceptibility levels of Anopheles arabiensis to insecticides used in malaria control, characterized basic mechanisms underlying resistance, and evaluated the role of public health use of insecticides in resistance selection.Methodology/Principal findingsSusceptibility status of An. arabiensis was assessed using WHO bioassay tests to DDT, permethrin, deltamethrin, malathion and propoxur in Ethiopia from August to September 2009. Mosquito specimens were screened for knockdown resistance (kdr) and insensitive acetylcholinesterase (ace-1R) mutations using AS-PCR and PCR-RFLP, respectively. DDT residues level in soil from human dwellings and the surrounding environment were determined by Gas Chromatography with Electron Capture Detector. An. arabiensis was resistant to DDT, permethrin, deltamethrin and malathion, but susceptible to propoxur. The West African kdr allele was found in 280 specimens out of 284 with a frequency ranged from 95% to 100%. Ace-1R mutation was not detected in all specimens scored for the allele. Moreover, DDT residues were found in soil samples from human dwellings but not in the surrounding environment.ConclusionThe observed multiple-resistance coupled with the occurrence of high kdr frequency in populations of An. arabiensis could profoundly affect the malaria vector control programme in Ethiopia. This needs an urgent call for implementing rational resistance management strategies and integrated vector control intervention.
Chitosan biosorbents for the recovery of palladium and platinum from aqueous waste streams.
BackgroundIn Ethiopia, although there are numerous small-scale and medium industries which use lead-based raw materials that may pose health risks to workers, there are no workplace regulations for lead exposure. Moreover, there are no studies carried out on the blood lead levels (BLLs) of workers or on the contribution of common workplace practices to lead poisoning.MethodA cross-sectional study on the BLLs of 45 automotive garage workers and 40 non-garage workers was carried out in the town of Jimma, Ethiopia. In addition to BLL analysis, data on some risk factors such as smoking, and chewing ‘khat’ (the leaves of Catha adulis) were gathered through structured questionnaires and interviews and data analysis was performed using SPSS (version 16). The t-test was used to compare mean BLLs of study groups. The analysis of variance (ANOVA), Kruskal-Wallis, Pearson chi-square and odds ratio tests were used to investigate the associations between specific job type, smoking and/or ‘khat’ chewing, service years and occurrence of non-specific symptoms with BLLs.ResultsThe mean BLL of the automotive-garage workers was found to be significantly greater than that of the controls. The BLLs of all the lead-exposed individuals were found to be over 10 μg/dL, and 53% of them had BLLs ranging 12 – 20 μg/dL, with the remaining 47% having over 20 μg/dL. The BLL of the workers increased with the duration of working in an automotive garage.Individuals involved in manual car painting comprise a larger percentage (58%) of those with the highest BLLs (≥ 20 μg/dL). Lead accumulation in individuals who chew ‘khat’ in the work place was found to be faster than in those who are not used to chewing ‘khat’. ‘Khat’ is an evergreen shrub native to tropical East Africa, with dark green opposite leaves which are chewed when fresh for their stimulating effects.ConclusionThe findings of the study have clearly demonstrated that the BLLs of automotive-garage workers in Jimma town are considerably high with a range of 11.73 – 36.52 μg/dL and the workers are in danger of impending lead toxicity. The BLLs of the workers are influenced by their occupational practices, chewing Catha adulis leaves at the workplace, and the time spent working in an automotive garage.
In different regions across the globe, elevated arsenic contents in the groundwater constitute a major health problem. In this work, a biopolymer chitosan has been blended with volcanic rocks (red scoria and pumice) for arsenic (V) removal. The effect of three blending ratios of chitosan and volcanic rocks (1:2, 1:5 and 1:10) on arsenic removal has been studied. The optimal blending ratio was 1:5 (chitosan: volcanic rocks) with maximum adsorption capacity of 0.72 mg/g and 0.71 mg/g for chitosan: red scoria (Ch–Rs) and chitosan: pumice (Ch–Pu), respectively. The experimental adsorption data fitted well a Langmuir isotherm (R2 > 0.99) and followed pseudo-second-order kinetics. The high stability of the materials and their high arsenic (V) removal efficiency (~93%) in a wide pH range (4 to 10) are useful for real field applications. Moreover, the blends could be regenerated using 0.05 M NaOH and used for several cycles without losing their original arsenic removal efficiency. The results of the study demonstrate that chitosan-volcanic rock blends should be further explored as a potential sustainable solution for removal of arsenic (V) from water.
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