The authors identify five primary prevention programming precepts dealing with perspective, targets, methods, intentionality, and ethic. They describe how the United States Department of Education's Fund for the Improvement of Post Secondary Education (FIPSE) sponsored University of Cincinnati substance abuse prevention project was developed by following these precepts. They hope that this information will aid others in their development of primary prevention programs in college substance abuse (i.e., alcohol and other drug abuse) or in other areas.