A self-selected sample of 4695 university and college students participated in a short-term evaluation of an interactive CD-ROM addressing harm reduction for alcohol use. The CD-ROM (Alcohol 101) uses a mix of video, text, music, graphics, and animation elements to present behavioral change strategies for safe and responsible use of alcohol. Student learning about alcohol as measured by self-report was generally in the desired direction and supportive of the impact of the CD-ROM on understanding of the physiological impact of alcohol and the range of behavioral options for pacing consumption and helping friends in potential peril.