Frequent detection of cytomegalovirus in the intestine of patients with inflammatory bowel disease

Abstract

Patients with ulcerative colitis had more often detectable CMV genome in their blood as well as in their intestinal tissue samples as compared with controls (P = 0.022 and P < 0.0001, respectively). However, patients with Crohn's disease had more often detectable CMV genome only in their intestinal tissue samples as compared with controls (P = 0.001). Detection of CMV genome in blood or intestinal tissue was significantly associated with short duration of IBD (P = 0.0088 and 0.04, respectively) but not with age, sex, severity of the disease, activity at colonoscopy, pancolitis, administration of a specific treatment, and surgery. In this cross-sectional prospective study, detection of CMV genome or antigen in the intestine was commonly associated with IBD.

Toxic Megacolon Associated with Cytomegalovirus Infection in a Patient with Steroid-naïve Ulcerative Colitis

“…Colonic infection with cytomegalovirus (CMV) has been increasingly implicated in inflammatory bowel disease (IBD) (1)(2)(3). In an immunocompromised host, a primary CMV infection or the reactivation of a latent CMV infection can cause severe disseminated disease, including colitis (4).…”

Prevalence, predictive factors and ideal treatment of cytomegalovirus infection in IBD patients

“…Several studies have assessed CMV positivity in surgical specimens among UC patients who underwent colectomy, and found a strong relationship between CMV colitis and steroid-refractoriness or development of toxic megacolon. Kambhan et al (15) compared the histopathological features of steroid-responsive and steroid-refractory UC patients and showed that CMV colitis was significantly more prevalent in refractory patients, and several studies found high prevalences of CMV colitis among IBD patients with active disease, ranging from 15.8-27.1% (5,19).…”

“…CMV infection in the GI tract may develop in all locations, from the mouth to the rectum, and it generally manifests with formation of ulcers on the mucosa, frequently accompanied by hemorrhage (1). In immunocompromised IBD patients, the risk for CMV infection rises, although it does not always lead to clinically active disease (19) or the necessity of treatment.…”

Diagnóstico y manejo de colitis ulcerosa grave: Una mirada actualizada

“…Estudios de cohorte informan una prevalencia de reactivación viral que varía entre 4,6 y 25% [38][39][40][41][42][43][44] .…”

“…La detección tisular es superior a las técnicas en sangre, ya que permite buscar evidencia de replicación local en biopsias de colon, ya sea mediante tinción con hematoxilina-eosina (sensibilidad 30-50%), inmunohistoquímica (IHQ, sensibilidad 60-90%) o reacción de polimerasa en cadena (RPC, sensibilidad mayor a 90%) 29,31,49 . En las publicaciones más recientes, las técnicas más utilizadas son inmunohistoquímica o RPC en biopsia de mucosa colónica, dada su mayor sensibilidad [38][39][40][41][42][43] .…”