Prevalence, predictive factors and ideal treatment of cytomegalovirus infection in IBD patients

Köroğlu, Emine; Çelık, Aykut Ferhat

doi:10.4318/tjg.2012.0622

Cited by 1 publication

(2 citation statements)

References 28 publications

(30 reference statements)

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“…The real-time tissue PCR assay that allows more sensitive and rapid detection of CMV-DNA in clinical samples has also been widely used in clinical practice. 13 This data type is not available in the NIS database. In our study, by only including the IBD patients who have received either sigmoidoscopy or colonoscopy, the patients with CMV disease or infection more likely had CMV colitis.…”

Section: Discussionmentioning

confidence: 99%

“… 5 , 6 In IBD patients, because CMV disease or infection most commonly involves the colon 3 , 4 , 10 , 11 and CMV activates and replicates more often in inflamed colonic mucosa, 12 for the diagnosis of gastrointestinal CMV in IBD patients, detection of CMV inclusion bodies in biopsy specimens from the gastrointestinal mucosa either by hematoxylin and eosin or immunohistochemistry have been widely accepted. 13 Therefore, in our study, we only included patients with IBD who had undergone either sigmoidoscopy or colonoscopy during the hospitalizations.…”

Section: Methodsmentioning

confidence: 99%

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Cytomegalovirus-Related Hospitalization Is Associated With Adverse Outcomes and Increased Health-Care Resource Utilization in Inflammatory Bowel Disease

Zhang

Krishna

Hinton

et al. 2016

Clinical and Translational Gastroenterology

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Objectives:Impact of cytomegalovirus (CMV)-related hospitalization in inflammatory bowel disease (IBD) patients is unknown. The aim of this study was to determine hospital outcomes of CMV-related hospitalization in IBD patients in a large national in-patient administrative data set.Methods:This was a cross-sectional study using data from the Nationwide In-patient Sample database. IBD- and CMV-related hospitalizations between 2003 and 2011 were identified using appropriate ICD-9-CM (International Classification of Diseases, Ninth Revision, Clinical Modification) codes. Impact of CMV-related hospitalization on in-hospital mortality, length of stay (LOS), and hospital charges were quantified.Results:CMV-related hospitalization was associated with higher in-hospital mortality (odds ratio (OR) 7.09, 95% confidence interval (CI) 3.38–14.85), prolonged LOS (7.77 days, P<0.0001), and more hospital charge (US$66,495, P<0.0001) in IBD patients.Conclusions:CMV-related hospitalization in IBD is associated with high in-hospital mortality, prolonged LOS, and hospital care costs.

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Section: Discussionmentioning

confidence: 99%