Frequency of CCR5-Δ32 deletion in human immunodeficiency virus type 1 (HIV-1) in healthy blood donors, HIV-1-exposed seronegative and HIV-1-seropositive individuals of southern Brazilian population

Abstract

Abstract. The frequency of CCR5-Δ32 allele in human immunodeficiency virus type 1 (HIV-1) infection in the southern Brazilian population was determined in a crosssectional study carried out from

The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

“…The CCR5-∆32 allele has been found in Brazilian populations in frequencies between 2.2-6.8% (Munerato et al 2003, Vargas et al 2006, Reiche et al 2008, Rigatto et al 2008. Here, we found a frequency of 2.4%.…”

“…Similarly, in another study conducted in Southern Brazil, the CCR5-∆32 frequency was 2.9% among HIV-1 seropositive patients with AIDS, 5.6% among those seropositive and asymptomatic, 5.6% in healthy blood donors and 5.51% in HIV-1-exposed seronegative subjects. CCR5-Δ32 allelic frequencies were not different when the self-reported racial characteristics of the individuals evaluated were considered (Reiche et al 2008). This allele has not been found among South American native Indians, corroborating the hypothesis of a european origin of this allele and its introduction to the continent through migration (Leboute et al 1999).…”

“…The Brazilian population presents a complex genetic background, characterised by a high degree of miscegenation (Callegari-Jacques et al 2003, Pena 2005. In major Brazilian cities, CCR5-∆32 was found at frequencies of between 2-7% (Munerato et al 2003, Vargas et al 2006, Reiche et al 2008, Rigato et al 2008, CCR5-59029A between 39-44% (Rigato et al 2008), CCR2-64I at approximately 10% (Munerato et al 2003, Rigato et al 2008) and SDF1-3'A between 18-22% (Reiche et al 2006, Rigato et al 2008. Despite the moderate rates of HIV infection reported in Brazil, little is known about the influence of genetic polymorphisms on HIV disease progression in this population.…”

Association of Chediak-Higashi Syndrome and Human Immunodeficiency Virus Type 1 Acute Infection

“…The control of the infection progression is regulated by the balance between host and viral factors. Human allelic variants do not only interfere in the susceptibility to HIV-1 infection, but also in the subsequent rates of disease progression towards AIDS [13][14][15][16][17][18][19]. Regarding the association of the CHS with HIV-1, studies have reported that the secretory pathway in CD4 + T cells supports HIV-1 cell-to-cell spread at the virological sinapse [20,21].…”

Analysis of Immunological, Viral, Genetic, and Environmental Factors That Might Be Associated with Decreased Susceptibility to HIV Infection in Serodiscordant Couples in Florianópolis, Southern Brazil

“…Studies investigating serodiscordant couples have previously described some factors associated with protection among HESN, such as the presence of the 32-base-pair (bp) deletion in chemokine CC receptor 5 (CCR5D32), 2 differences in T cell reactivity to HIV, 3 and the presence of cationic peptides in cervicovaginal secretions. 4 Although Brazil has the largest number of HIV-infected people among the countries in Central and South America, 5 and an ethnically very diverse population, 6 there is a paucity of information regarding cohorts of serodiscordant couples.…”