Analysis of Immunological, Viral, Genetic, and Environmental Factors That Might Be Associated with Decreased Susceptibility to HIV Infection in Serodiscordant Couples in Florianópolis, Southern Brazil

SantosÍris, M; RosaElis, A da; Gräf, Tiago; FerreiraLuiz, G E; PetryAndrea,; CavalheiroFernanda,; Reiche, Edna Maria Vissoci; ZanettiCarlos, R; Pinto, Aguinaldo Roberto

doi:10.1089/aid.2015.0168

Cited by 6 publications

(8 citation statements)

References 45 publications

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“…However, inconsistent results have been reported by other researchers; for example, Gonzalez et al (13) demonstrated that SAMHD1 expression was higher in the oral and genital mucosa and lower in the PBMcs of HeSn individuals who were resistant to HiV-1compared with Hcs. in addition, Santos et al (14) reported that no significant differences were observed in the basal SAMHD1 mRNA expression levels in the CD4 + T cells of HeSn individuals compared with those of HCs and HIV-ARTs. The results of the present study revealed higher SAMHD1 expression in the CD4 + T cells of ecs compared with those of Hcs, which was consistent with the findings of the study by Riveira-Muñoz et al (12).…”

Section: Discussionmentioning

confidence: 98%

“…VPs, suggesting that SAMHD1 may serve a role in controlling viral replication and slowing the rate of disease progression. However, conflicting results were reported in HIV-exposed seronegative (HESN) individuals in other studies (13,14). Therefore, SAMHD1 expression in the peripheral blood of patients with HIV-1, especially in CD4 + T cells, should continue to be investigated.…”

Section: Samhd1 Expression Is Associated With Low Immune Activation Bmentioning

confidence: 96%

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SAMHD1 expression is associated with low immune activation but not correlated with HIV‑1 DNA levels in CD4+ T cells of patients with HIV‑1

Gao

Huang

et al. 2020

Mol Med Rep

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Sterile α motif and histidine/aspartic acid domain-containing protein 1 (SaMHd1) can inhibit reverse transcription of human immunodeficiency virus-1 (HIV-1) by hydrolyzing intracellular deoxy-ribonucleoside triphosphate. However, its role in HiV-1 disease progression has not been extensively studied. To study the impacts of SAMHD1 on HIV-1 disease progression, especially on DNA levels, we investigated SaMHd1 levels in the peripheral blood of HIV-1 elite controllers (ECs), antiretroviral therapy (arT) naive viremic progressors (VPs) and patients with HIV-1 receiving ART (HIV-ARTs) compared with healthy controls. In addition, the present study analyzed the relationship between SaMHd1 and interferon-α, immune activation and HiV-1 dna levels. The results of the present study demonstrated elevated SAMHD1 expression in the peripheral blood mononuclear cells of all patients withHiV-1, but higher SAMHD1 expression in the CD4 + T cells of only ECs compared with healthy controls. Immune activation was increased in the VPs and decreased in the ecs compared with healthy controls. Substantially lower HIV-1 DNA levels were identified in ecs compared with those in VPs and HIV-ARTs. SAMHD1 expression was associated with low levels of immune activation. No significant correlation was observed between SaMHd1 and HiV-1 dna levels. overall, the findings of the present study indicated that SAMHD1 was highly expressed in ECs, which may be associated with low immune activation levels, but was not directly related to HiV-1 dna levels.

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Section: Discussionmentioning

confidence: 98%

Section: Samhd1 Expression Is Associated With Low Immune Activation Bmentioning

confidence: 96%

SAMHD1 expression is associated with low immune activation but not correlated with HIV‑1 DNA levels in CD4+ T cells of patients with HIV‑1

Gao

Huang

et al. 2020

Mol Med Rep

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“…Cuando se analizaron los diferentes tipos de cohortes de HESN, se evidenció una pluralidad en la distribución de dichas cohortes. La diversidad de HESN hallada en este estudio es similar a lo descrito por otros investigadores que estudian mecanismos relacionados con la resistencia al VIH-1 (11). El predominio de estudios en parejas serodiscordantes puede explicarse porque la principal vía de contagio del virus es la sexual (11,14), de manera que en esta población se puede establecer con mayor certeza la exposición al VIH-1 (mientras se tenga en cuenta la inclusión de parejas monógamas, tanto homosexuales como heterosexuales, en las que se practiquen relaciones sexuales sin protección).…”

Section: Discussionunclassified

“…Entre los factores inmunológicos se destaca la producción de diferentes quimiocinas que se unen al CCR5 (RANTES, MIP-1a, MIP-1b), los anticuerpos anti-VIH-1 (IgG e IgA), la activación de células T específicas del VIH-1 y las células NK y factores solubles en mucosas, que son el principal sitio de entrada del VIH-1 (10). Debido a que estos factores no están presentes en todos los HESN, se sugiere que la resistencia natural a la infección por el VIH-1 es un evento multifactorial en el que se ven involucrados tanto aspectos del hospedero como del virus (11).…”

Section: Introductionunclassified

Resistencia natural a la infección por el VIH-1. Revisión sistemática de la literatura

Higuita-Gutiérrez

Zapata

Alarcón-Uribe

2023

Iatreia

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Introducción: la investigación sobre la infección por el VIH-1 ha permitido identificar individuos que, a pesar de exponerse en múltiples ocasiones al virus, no presentan signos de infección. Se les conoce como expuestos a VIH seronegativos o HESN (del inglés HIV-exposed seronegative). Esto sugiere la existencia de mecanismos de resistencia natural al VIH-1.Objetivo: describir la información disponible en la literatura sobre los HESN y sus mecanismos de resistencia natural.Métodos: se realizó una revisión sistemática de la literatura de enfoque amplio en seis bases de datos y se siguieron las etapas de la guía PRISMA. El análisis de la información se hizo con frecuencias absolutas, relativas y con un análisis de redes de colaboración científica en Ghepi.Resultados: se encontraron 124 artículos de 24 países que en total suman 4079 individuos HESN. La comunidad científica interesada en este tema estuvo conformada por 688 investigadores de Estados Unidos, Italia, Canadá, España, Brasil y Colombia. Los criterios para definir a un individuo como HESN fueron altamente variables. Se identificaron 33 mecanismos diferentes relacionados con la resistencia natural al VIH-1, dentro de los cuales el más común fue los factores solubles (en mucosas y sangre periférica) (30,6 %), seguido por la mutación Δ32 (14,5 %), los alelos KIR/HLA (10,5 %) y la IgA neutralizante (10,5 %).Conclusión: existe una comunidad científica consolidada con interés en estudiar la resistencia natural a la infección por VIH-1. Se observó una significante diversidad en los mecanismos inmunológicos involucrados en la resistencia natural al virus y se demostró una alta heterogeneidad en los criterios para definir las poblaciones como HESN.

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“…This insinuates that performing only a metagenomic study may not be a perfect snapshot of functional active genes in a metagenome. To overcome the tedious isolation of viral mRNA from total mRNA, SCG can be conducted along with microarrays to designate the phage-host systems without cultivating them (Santos I. M. et al, 2015). In another study, phage-host pairs have been investigated in which a fosmid viral metagenomic library was constructed and immobilized on microarray “virochip,” along with them.…”

Section: Employing Transcriptomics To Study Active Phage Functionmentioning

confidence: 99%

Intriguing Interaction of Bacteriophage-Host Association: An Understanding in the Era of Omics

et al. 2017

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Innovations in next-generation sequencing technology have introduced new avenues in microbial studies through “omics” approaches. This technology has considerably augmented the knowledge of the microbial world without isolation prior to their identification. With an enormous volume of bacterial “omics” data, considerable attempts have been recently invested to improve an insight into virosphere. The interplay between bacteriophages and their host has created a significant influence on the biogeochemical cycles, microbial diversity, and bacterial population regulation. This review highlights various concepts such as genomics, transcriptomics, proteomics, and metabolomics to infer the phylogenetic affiliation and function of bacteriophages and their impact on diverse microbial communities. Omics technologies illuminate the role of bacteriophage in an environment, the influences of phage proteins on the bacterial host and provide information about the genes important for interaction with bacteria. These investigations will reveal some of bio-molecules and biomarkers of the novel phage which demand to be unveiled.

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Analysis of Immunological, Viral, Genetic, and Environmental Factors That Might Be Associated with Decreased Susceptibility to HIV Infection in Serodiscordant Couples in Florianópolis, Southern Brazil

Abstract: Individuals who have been exposed to human immunodeficiency virus (HIV) and have not been infected might possess natural resistance mechanisms.

Cited by 6 publications

References 45 publications

SAMHD1 expression is associated with low immune activation but not correlated with HIV‑1 DNA levels in CD4+ T cells of patients with HIV‑1

SAMHD1 expression is associated with low immune activation but not correlated with HIV‑1 DNA levels in CD4+ T cells of patients with HIV‑1

Resistencia natural a la infección por el VIH-1. Revisión sistemática de la literatura

Intriguing Interaction of Bacteriophage-Host Association: An Understanding in the Era of Omics

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