Frequency of cannabis use during pregnancy and adverse infant outcomes, by cigarette smoking status – 8 PRAMS states, 2017

Haight, Sarah C.; King, Brian A.; Bombard, Jennifer M.; Coy, Kelsey; Ferré, Cynthia; Grant, Althea M.; Ko, Jean Y.

doi:10.1016/j.drugalcdep.2021.108507

Cited by 32 publications

(25 citation statements)

References 35 publications

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“…1 Several studies have demonstrated that prenatal cannabis use is associated with preterm birth, low birth weight, neurocognitive problems in neonates, and adverse neurodevelopmental outcomes in children. [2][3][4][5][6][7][8][9] However, with increasing legalization and social acceptance of cannabis, the prevalence of use among pregnant women is increasing, [10][11][12] as is reflected by the legalization of medical cannabis in 36 states and medical and recreational cannabis in 17 states as of April 2021. 13,14 Two recent studies found that women residing in states with legalized recreational cannabis were more likely to use in the perinatal period.…”

mentioning

confidence: 99%

Maternal Cannabis Use in the Perinatal Period: Data From the Pregnancy Risk Assessment Monitoring System Marijuana Supplement, 2016–2018

Sood

Trasande

Mehta‐Lee

et al. 2021

Journal of Addiction Medicine

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Objective: To estimate the prevalence of perinatal cannabis use (ie, before and/or during pregnancy); document the frequency, modes, and motivations for use; and identify predictors of perinatal cannabis use. Methods: Six states in the Pregnancy Risk Assessment Monitoring System, a state-specific, population-based surveillance system, administered a supplemental questionnaire on perinatal cannabis use in 2016-2018. Women with live births were surveyed 2-6 months postpartum about behaviors ≤ 3 months preconception and during pregnancy. Demographic, psychosocial, and behavioral characteristics were examined in relation to perinatal cannabis use using multinomial regression models. Those who: (1) never used cannabis, (2) only used in preconception period, and (3) used in both preconception and prenatal periods were compared. Results: Among 6428 respondents, 379 (5.8%) used cannabis preconceptionally only and 466 (4.4%) used in both the preconception and prenatal periods. Among those using prenatally, most reported smoking as their single mode (87.1%), with the two most common reasons being stress (83.8%) and nausea/vomiting (79.2%). Marital status, race/ethnicity, socioeconomic status, parity, and cigarette and alcohol use were significantly associated with perinatal cannabis use. Single (vs partnered) women were more likely to use cannabis prenatally (odds ratio = 2.4, 95% confidence interval: 1.5, 3.9) and non-Hispanic Black (vs White) women were less likely to use prenatally (odds ratio = 0.4, 95% confidence interval: 0.2, 0.8). Conclusions: Using a population-based sample of US births in six states, several demographic, psychosocial, and behavioral characteristics were identified in relation to perinatal cannabis use. These data are valuable for counseling in prenatal care and investigations of health effects.

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confidence: 99%

Maternal Cannabis Use in the Perinatal Period: Data From the Pregnancy Risk Assessment Monitoring System Marijuana Supplement, 2016–2018

Sood

Trasande

Mehta‐Lee

et al. 2021

Journal of Addiction Medicine

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“…The great majority of studies relied only on maternal self-report (n=14). The timing of self-report measurement varied between studies: during antenatal appointments 8,15,16,24,[31][32][33][34][35][36][37] ; at delivery 13,15,27,[38][39][40] ;or after delivery by telephone interview 14,[41][42][43] . Somestudies also included exposure to cannabis before pregnancy 14,24,42 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…The timing of self-report measurement varied between studies: during antenatal appointments 8,15,16,24,[31][32][33][34][35][36][37] ; at delivery 13,15,27,[38][39][40] ;or after delivery by telephone interview 14,[41][42][43] . Somestudies also included exposure to cannabis before pregnancy 14,24,42 . Eleven studies used maternal urine, hair or meconium test screening nine of them assessing cannabis exposure only once, either during pregnancy 8,15,16,29,30,4 or at the time of delivery 13,38,45 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Two studies 28,40 reported higher prevalence of PTB in women who used cannabis during the second and third gestational trimesters when compared to those who only used during the first trimester. Two studies identified significantly higher prevalence of LBW 42,43 and SGA 43 in women who reported high frequency of cannabis consumption (at least once a week), both in smoking and in nonsmoking women, and one study 27 reported a dose response effect for PTB (5.3, 9.9, and 12.3% in nonusers, in those who used less than once a month, and among more frequent users, respectively).…”

Section: Timing and Frequency Of Cannabis Use And Interaction With Ci...mentioning

confidence: 99%

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The Effects of Cannabis Use during Pregnancy on Low Birth Weight and Preterm Birth: A Systematic Review and Meta-analysis

Baía

Domingues

2022

Am J Perinatol

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Objective: to summarize literature regarding the effects of cannabis use during pregnancy on low birthweight (LBW), preterm birth (PTB) and small for gestational age (SGA). Study Design: systematic review and meta-analysis. A literature search was conducted in PubMed, Scopus, EBSCO and Web of Science in May 2021 and updated in November 2021. Only studies that assessed the isolated use of cannabis during pregnancy, controlling for cigarette smoking and other illicit drug use, were included. Data was synthesized using a narrative summary and pooled adjusted estimates and 95% confidence intervals (CI) were calculated for each outcome. Data was analyzed using Stata 13.0 with METAN software package, using random effects. Statistical heterogeneity was assessed using the Cochran´s Q and Higgins I2 tests. Results: 32 studies were included with data from approximately 5.5 million women for the LBW outcome and 23 million for the PTB and SGA outcomes. Pregnant women using cannabis are at increased risk for LBW (aOR= 1.52; 95%CI= [1.18;1.96]), PTB (aOR= 1.39; 95%CI= [1.28;1.51]), and SGA (aOR= 1.47; 95%CI= [1.38;1.58]). Studies that assessed type of preterm birth and gestational age at birth indicate higher risks of spontaneous PTB and of early or very-early preterm births associated with cannabis use during pregnancy. The few studies that assessed the timing and frequency of consumption suggest a dose-response effect, with higher odds of negative outcomes among women who reported heavy use and with continued use during the second and third trimester of gestation. Conclusion: There is an effect of cannabis irrespectively of other illicit drugs and tobacco, despite high heterogeneity and low quality of evidence. There is a need to discuss public policies regarding cannabis’ regulation and how it influences its consumption. Future studies should focus on the effects of cannabis’s type (medicinal or recreational), timing and dosage during pregnancy on perinatal outcomes.

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“…Previous studies have connected cannabis use to a constellation of health issues, including increased risk of sexually transmitted infection, mental health problems and pregnancy at a younger age (Chapman & Wu, 2013;De Genna et al, 2007), although more recent literature is needed. Cannabis use is increasingly understood to be unsafe for the pregnancy and growing fetus (Haight et al, 2021;Volkow et al, 2017). Both cannabis use and exposure to discrimination in adolescence appear to be correlated with elevated levels of stress hormones (Barton et al, 2018), which in turn may contribute to inflammation and poor cardiovascular health, including poor pregnancy outcomes (Brody et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Syndemics of Sexually Transmitted Infections in a Sample of Racially Diverse Pregnant Young Women

Hill

Méndez

Haggerty

et al. 2022

Matern Child Health J

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Introduction Syndemic theory posits that poor health outcomes co-occur and amplify each other in the context of harmful conditions that must be addressed simultaneously to improve health equity. This analysis identifies perinatal syndemic factors and examine how factors are related to STI in a sample of racially diverse young pregnant women. Methods Pregnant participants (n = 61) ages 14-21 from racially diverse backgrounds were recruited from a prenatal clinic for an ongoing longitudinal study between October 2019-February 2020. Participants completed a tablet survey assessing pregnancy intention, psychosocial factors (e.g., depression, stress, partner violence, pregnancy history) and consented to provide access to their medical records for STI and clinical urine samples screened for tobacco and cannabis use. Latent class analysis (LCA) was used to examine probabilities of co-occurring Syndemic indicators. Results Half of the women were Black (52%) and primigravida (54%). Three classes were identified in the LCA, two of them reflecting syndemics related to STI from the medical record. The largest class was half Black (51%), with a high rate of STI (65%), and was characterized by factors including depressive symptoms (93%), stress (64%), and substance use (65% cannabis, 82% tobacco). Additionally, the class with the highest rates of STI (74%) also had higher rates of partner violence (48%), morning sickness (100%), and prenatal cannabis use (63%). Conclusion Findings indicate evidence of a syndemic related to increased STI. A longitudinal evaluation of syndemics in this cohort may inform appropriately tailored intervention strategies to promote perinatal health in racially diverse young pregnant populations.

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Frequency of cannabis use during pregnancy and adverse infant outcomes, by cigarette smoking status – 8 PRAMS states, 2017

Cited by 32 publications

References 35 publications

Maternal Cannabis Use in the Perinatal Period: Data From the Pregnancy Risk Assessment Monitoring System Marijuana Supplement, 2016–2018

Maternal Cannabis Use in the Perinatal Period: Data From the Pregnancy Risk Assessment Monitoring System Marijuana Supplement, 2016–2018

The Effects of Cannabis Use during Pregnancy on Low Birth Weight and Preterm Birth: A Systematic Review and Meta-analysis

Syndemics of Sexually Transmitted Infections in a Sample of Racially Diverse Pregnant Young Women

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