Free sebaceous glands in the gingiva of some rats

Rulli, Mauro A.; Martinelli, C

doi:10.1016/0003-9969(71)90129-4

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…These results were essentially consistent with the data from previous investigators, suggesting that Fordyce's granules are more extensively seen in the anterior portion of the molars of aged males [9][10][11][12] . In Holtzman, Long-Evans, and Wistar strain rats, the locations of Fordyce's granules have been reported to be only in the anterior gingiva of the first upper or lower molar [9][10][11] . In contrast, the Fordyce's granules examined under the conditions of this study were often noted in the upper third molar gingiva as well as the first molar.…”

Section: Discussionsupporting

confidence: 83%

“…Additionally, the granules are recognized to occur frequently and bilaterally in the buccal, labial, retromolar mucosa, and vermilion border of the lip 2,[4][5][6] . In other species, Fordyce's granules have been reported as ectopic sebaceous glands in the soft palate of the guinea pig 7 , the lip of the chimpanzee 8 , and the gingiva of rats [9][10][11][12] . In rats, ectopic oral sebaceous glands have previously been reported in Holtzman, Long-Evans, Wistar, and F344 strains, and their morphological features closely resemble human Fordyce's granules used as a common name.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous Ectopic Sebaceous Glands (Fordyce's Granules) in the Oral Mucosa of Sprague-Dawley Rats

et al. 2003

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Although Sprague-Dawley rats are most frequently used in numerous toxicological studies, there are only few reports dealing with the spontaneous occurrence of ectopic sebaceous glands in the oral tissue (Fordyce's granules) so far. Hence, to clarify the morphological characteristics of Fordyce's granules with their incidence in this strain, 110 male and 110 female CD(SD)IGS rats aged 19 to 112 weeks were examined microscopically. Fordyce's granules were identified in the upper molar gingiva, and most of them were located around the first and third molars. The granules consisted of one or more sebaceous glands without hairs and hair follicles, and had some lobules comprising acini with adipose vacuoles. The short excretory duct was lined with stratified squamous cells and drained to the gingival surface. The sebum constituting disintegrated acinar cells in the duct was also noted. In some cases, the granules were accompanied by cystic dilatation in the ducts and/or inflammatory reactions, without neoplastic or pre-neoplastic lesions. The overall incidence (9.1%) of Fordyce's granules in males was higher than that (0.9%) in females, and it somewhat increased with ascending ages, demonstrating sex-or age-specific difference. Based on the above findings, the nature of Fordyce's granules seen in CD(SD)IGS rats was similar to those of other strains and humans. (J Toxicol Pathol 2003; 16: 253-257)

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Spontaneous Ectopic Sebaceous Glands (Fordyce's Granules) in the Oral Mucosa of Sprague-Dawley Rats

et al. 2003

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“…In 197 1, however, the granules were incidentally found in Wistar rats with an experimental bacterial infection of the pulp. 15 In F344 rats, we found Fordyce's granules not only in the molar gingiva but also in the upper incisor gingiva. The incidence of the granules was prominently different in terms of age, sex, and gingival site.…”

mentioning

confidence: 70%

Fordyce's Granules of the Incisor and Molar Gingiva in F344 Rats

1990

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Abstract. Fordyce's granules were observed in the gingiva of the upper incisor and molar teeth in F344 rats. The data were based on 734 males and 722 females that were used as control and treated animals in 26-week, 65-week, and 2-year studies by the National Toxicology Program. The incidence of Fordyce's granules was markedly different when comparing sex, age, and site of the lesion. Fordyce's granules were very common in the midsagittal gingiva of the upper incisor in males and increased in incidence with age (34.2, 50, and 56.3% in 26-week, 65-week, and 2-year studies, respectively). The granules of the incisor gingiva were rare in females (0, 0, and 2.8% in 26-week, 65-week, and 2-year studies, respectively). Fordyce's granules of the molar gingiva were very rare in both sexes and were found only in 9/734 (1.29'0) males and in 3/722 (0.4%) females. Only three unilateral granules of the molar were grossly recognized as focal swelling of the gingiva or a white nodule with a huge cyst in the third upper molar. Histologically, Fordyce's granules were arranged as a collection of sebaceous glands unassociated with hair follicles. In addition, the granules of the molar gingiva were associated with cystically dilated ducts filled with sebum. Ultrastructurally, the sebaceous cells were characterized by varying numbers of cytoplasmic lipid droplets and occasional desmosome and hemidesmosome formation. Fordyce's granules previously reported in rats of other strains were also reviewed and compared with those in F344 rats in regard to incidence, location, and age.

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“…In rats, there are, at present, only four reports of intraoral 'ectopic' sebaceous glands in the literature (Bernick & Bavetta 1962, Frandsen 1962, Rulli & Martinelli 1971, Yoshitomi et al 1990. In Holtzman and Long-Evans rats, as well as in Wistar rats, Fordyce's granules are found in the molar gingiva.…”

Section: Gastrointestinal Systemmentioning

confidence: 99%

Wistar and Sprague–Dawley rats

McInnes¹

2012

Background Lesions in Laboratory Animals

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Free sebaceous glands in the gingiva of some rats

Cited by 7 publications

References 3 publications

Spontaneous Ectopic Sebaceous Glands (Fordyce's Granules) in the Oral Mucosa of Sprague-Dawley Rats

Spontaneous Ectopic Sebaceous Glands (Fordyce's Granules) in the Oral Mucosa of Sprague-Dawley Rats

Fordyce's Granules of the Incisor and Molar Gingiva in F344 Rats

Wistar and Sprague–Dawley rats

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