Free radical scavenging and radioprotective activity of dehydrozingerone against whole body gamma irradiation in Swiss albino mice

Preclinical Evaluation of DMA, a Bisbenzimidazole, as Radioprotector: Toxicity, Pharmacokinetics, and Biodistribution Studies in Balb/c Mice

“…Radiotherapy, second only to surgery, is used with 80% of patients as one of the most effective modalities for the treatment and cure of neoplastic diseases (Nair et al, 2001;Parihar et al, 2007;Satyamitra et al, 2012). Ionizing radiation triggers a series of events starting from generation of reactive oxygen species (ROS).…”

Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis

“…Several defense systems are involved in protection from oxidative stress, among which reduced glutathione (GSH) occupies a prominent position as the main water-soluble non-enzymatic antioxidant (Dringen et al 2000). Radioprotective agents are those administered before exposure to ionizing radiation to reduce the damaging effects for normal cells, including radiation-induced lethality (Parihar et al 2007). Many synthetic as well as natural agents have the efficacy as a protector against radiation injuries (Nair et al 2001).…”

Plant Extracts and Plant-Derived Compounds: Promising Players in Countermeasure Strategy Against Radiological Exposure: A Review

“…Adding to its advantage is also the easy availability of the plants, which are consumed in one form or the other across the globe. As shown in Table 1 DOI:http://dx.doi.org/10.7314/APJCP.2014.15.6.2405 radicals are known to be generated in vivo because of radiation exposure (Parihar et al, 2007;Swarts et al, 2007;Sharan et al, 2011;Peebles et al, 2012;Francois et al, 2013;Mikhailenko et al, 2013), and hence scavenging them can protect the cells or tissue from oxidative injury. At the same time, some of the plants/plant-derived compounds also induce the biological antioxidant defence system such as SOD, GSH, CAT and GPx to counter the radiological effects in experimental animals in order to prevent cell/tissue injury.…”

“…The hallmark late effect of radiation exposure in several experimental animals is fibrosis, which is often permanent (Han et al, 2006;Lee et al, 2009;Flechsig et al, 2010;Qiu et al, 2011;Gorshkova et al, 2012;Cho et al, 2013;Ding et al, 2013;Horton et al, 2013). A number of chemical agents showed mitigation to radiation-induced injuries in animal models (Gandhi and Nair, 2004;Parihar et al, 2007;Thotala et al, 2009;Brown et al, 2010;Gao et al, 2012;Kma et al, 2012;Peebles et al, 2012;Alok et al, 2013;Copp et al, 2013).…”