Free radical scavenging activity of Berberine in acetaminophen induced liver injury

Almani, Suhail Ahmed; Qureshi, Fatima; Shaikh, Tariq Zaffar; Uqaili, Arslan Ahmed; Khoharo, Haji Khan

doi:10.5455/ijsm.berberine-in-acetaminophen-induced-liver-injury

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Berberine is reported to be useful in the Indian traditional system since a long time for various ailments, including diabetes, hyperlipidemia, oxidative stress, cancer and inflammation [6][7][8][9]. Berberine is reported to exhibit antidiabetic activity through promoting regeneration and functional recovery of β-cells as well as by improvement of insulin sensitivity [10,11]. Considering the role of berberine as an insulin sensitizer, we have undertaken the present study with an objective to evaluate the effect of berberine on diabetic nephropathy and cardiomyopathy in HFDlow dose STZ induced type II diabetes in rats.…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Berberine in Ameliorating Diabetic Complications in Streptozotocin-High Fat Diet Model in Experimental Animals

Bandawane¹,

Mooliya²,

Jadhav³

2020

Int J Pharm Pharm Sci

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Objective: Diabetes mellitus is a serious, complex metabolic disorder and growing health threat disease in the world. Berberine, one of the main constituent in Rhizoma coptidis is widely used in the treatment of diabetes. Potential of berberine in the management of diabetic complications, namely diabetic nephropathy and cardiomyopathy, is however, not yet explored. The present study was, therefore, undertaken to explore the potential of berberine for the management of diabetic nephropathy and diabetic cardiomyopathy in high-fat diet (HFD) and low dose streptozotocin (STZ) induced diabetes in rats. Methods: Rats were fed a high-fat diet for 4 w followed by a single intraperitoneal dose of streptozotocin (35 mg/kg). Animals were divided in five groups. Berberine was given orally in two different dose levels (75 mg/kg and 150 mg/kg) for 28 d. Metformin (100 mg/kg) was used as a standard antidiabetic drug. At the end of the study, parameters evaluated includes glycemic profile, lipid profile, left ventricular indices, urinary protein, serum creatinine, blood urea nitrogen and cardiac antioxidants. Histopathology of kidney and pancreas was carried out. Results: Berberine treated groups showed a significant decrease in fasting blood glucose, glycosylated Hb, creatinine, blood urea nitrogen and urinary total proteins, whereas there was a significant improvement in serum insulin, liver glycogen, skeletal muscle glycogen and cardiac antioxidant enzymes. Conclusion: Present study indicated that berberine shows a protective role in diabetes-associated renal and cardiovascular complications.

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Section: Introductionmentioning

confidence: 99%

Protective Role of Berberine in Ameliorating Diabetic Complications in Streptozotocin-High Fat Diet Model in Experimental Animals

Bandawane¹,

Mooliya²,

Jadhav³

2020

Int J Pharm Pharm Sci

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“…Three replicates for each parameter were analyzed statistically with the help of Statistix 10.0 to find the significance level and to determine the comparison of means according to the method described by Almani et al. (2017).…”

Section: Methodsmentioning

confidence: 99%

Nutraceutical activities of Trigonella foenum‐graecum and Nigella sativa seeds in the management of diabetes‐induced in albino rats

Shahid,

Arshad,

Munir

et al. 2024

Journal of Food Science

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Diabetes causes elevated blood sugar levels, and it has been categorized as one of the most frequent causes of death worldwide. This work aimed to analyze and compare the nutraceutical and therapeutic efficacy of fenugreek seeds (FSs) (Trigonella foenum‐graecum) and black cumin seeds (BCSs) (Nigella sativa) against streptozotocin‐induced diabetes mellitus in albino rats. FS and BCSs were evaluated for proximate analysis, phytochemicals, and antioxidant activities. Male albino rats were used to evaluate the in vivo antidiabetic activities of these medicinal plants for 42 days. Blood samples were drawn at regular intervals of 1 week to analyze blood glucose, plasma insulin, and cholesterol levels and to determine the homeostatic model assessment of insulin resistance (HOMA IR) index. At the end of the trial, pancreas tissue was also collected for histological examination. Results of the proximate analysis showed the significant presence of moisture, ash, fat, protein, and fiber. Antioxidant parameters like 2,2‐diphenyl‐1‐picrylhydrazyl, total phenolic content, and total flavonoid content were found to be significant. There was a significant (p < 0.05) decrease in blood glucose level, serum cholesterol level, and insulin resistance in treatment groups T3–T5. Insulin and body weight results of treatment groups were significant (p < 0.05) compared to streptozotocin‐intoxicated animals. Histological examination revealed the nutraceutical impact of selected herbal plants due to enhancing impact on the size and the number of β‐cells in the pancreas. Findings of current research work explore the antidiabetic capacity of selected nutraceutical and medicinal plants.

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“…Currently 415 million of World population is suffering from DM, and is estimated to 624 million by the 2040 year [1]. DM claims 5 million lives yearly, mainly by the coronary artery and chronic renal diseases [1,2]. Diabetic causailities may be reduced by tight glycemic control [3].…”

Section: Introductionmentioning

confidence: 99%

Effects of Berberine on Bloog Glucose, Glycated Hemoglobin A1, Serum Insulin, C–Peptide, Insulin Resistance and β– Cell Physiology

Khoharo

Shaikh

Nizamani

et al. 2020

JPRI

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Objective: Determine effects of berberine (BBR) on bloog glucose, glycated hemoglobin A1, serum insulin, C – peptide, insulin resistance and β– cell physiology. Study Design: Experimental study Place and Duration: Department of Physiology Isra University and Animal house of Sindh Agriculture University, Tando Jam from August 2019 to February 2020. Methodology: A sample of 100 adult Wistar male rats was selected according to criteria of study and divided into 5 groups through random technique. Group A – negative controls (N/S 0.9%), Group B – positive control (diabetic rats – Alloxan 120 mg/kg) (i.p), Group C – E; Diabetic rat + BBR (50, 100 and 200 mg/kg) respectively. Blood samples were collected from retro-orbital venous plexus by capillary tube. Sera were separated at 3000 rpm (15 minutes). Insulin resistance (HOMA-IR) and β – cell secretory activity (HOMA-β) were calculated by mathematical formula. Statistical analysis was performed on SPSS version 21.0 (IBM, incorporation, USA) at 95% CI (P≤ 0.05). Results: The present study noted significant improvement of fasting and random blood glucose, glycated HbA1, serum insulin and C –peptide, insulin resistance (HOMA-IR) and β – cell physiology. Conclusion: Berberine (BBR) ameliorates the bloog glucose, glycated hemoglobin A1, serum insulin, c – peptide, insulin resistance and β– cell physiology.

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Free radical scavenging activity of Berberine in acetaminophen induced liver injury

Cited by 3 publications

References 21 publications

Protective Role of Berberine in Ameliorating Diabetic Complications in Streptozotocin-High Fat Diet Model in Experimental Animals

Protective Role of Berberine in Ameliorating Diabetic Complications in Streptozotocin-High Fat Diet Model in Experimental Animals

Nutraceutical activities of Trigonella foenum‐graecum and Nigella sativa seeds in the management of diabetes‐induced in albino rats

Effects of Berberine on Bloog Glucose, Glycated Hemoglobin A1, Serum Insulin, C–Peptide, Insulin Resistance and β– Cell Physiology

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