Free radical scavenging activity of coenzyme Q measured by a chemiluminescent assay

Battino, Maurizio; Ferri, Elida Nora; Girotti, Stefano; Lenaz, Giorgio

doi:10.1016/0003-2670(91)80070-a

Cited by 16 publications

(10 citation statements)

References 13 publications

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“…However, growing evidence indicates that vitamin E is not always the best lipophilic anti-oxidant (Battino et al, 1991a;Stocker et al, 1991) and, even worse, that vitamin E can also act as a pro-oxidant (Bowry et al, 1992;Bowry and Stocker, 1993;Kontush et al, 1996;Stocker and Bowry, 1996). According to the anti-oxidant view, vitamin E inhibits lipid peroxidation, scavenging peroxyl radicals much faster than these radicals can react with adjacent fatty acid side-chains or with membrane proteins (Gutteridge and Halliwell, 1994): The peroxyl radical is converted to a lipid peroxide and ox-tocopherol to an cx-tocopheroxyl radical which, in turn, is alternatively regenerated to ot-tocopherol by ubiquinol (CoQH2: the reduced form of co-enzyme Q), GSH, or, mainly, by ascorbic acid.…”

Section: Vitamin E (0l-tocopherol)mentioning

confidence: 99%

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Oxidative Injury and Inflammatory Periodontal Diseases : the Challenge of Anti-Oxidants to Free Radicals and Reactive Oxygen Species

Battino

Bullón

Wilson

et al. 1999

Critical Reviews in Oral Biology & Medicine

282

266

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ABSTRACT. In recent years, there has been a tremendous expansion in medical and dental research concerned with free radicals, reactive oxygen species, and anti-oxidant defense mechanisms. This review is intended to provide a critical, up-to-date summary of the field, with particular emphasis on its implications for the application of "anti-oxidant therapy" in periodontal disease. We have reviewed the nomenclature, mechanisms of actions, features, and sources of most common free radicals and reactive oxygen species, as well as analyzed the typical biological targets for oxidative damage. Based on a review of direct and indirect anti-oxidant host defenses, particularly in relation to the key role of polymorphonuclear neutrophils in periodontitis, we review current evidence for oxidative damage in chronic inflammatory periodontal disease, and the possible therapeutic effects of anti-oxidants in treating and/or preventing such pathology, with special attention to vitamin E and Co-enzyme Q.

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Section: Vitamin E (0l-tocopherol)mentioning

confidence: 99%

“…The investigations carried out by Battino and co-workers (Battino et al, 1991a(Battino et al, ,b, 1993(Battino et al, , 1997aHuertas et al, 1991;Ferri et al, 1994;Quiles et al, 1994;Atleva et al, 1995;Littarru et al, 1996;Armeni et al, 1997;Lodi et al, 1997;Mataix et al, 1997) (Kagan et al, 1996).…”

Section: Coqo10h2 Reduced Form)mentioning

confidence: 99%

Oxidative Injury and Inflammatory Periodontal Diseases : the Challenge of Anti-Oxidants to Free Radicals and Reactive Oxygen Species

Battino

Bullón

Wilson

et al. 1999

Critical Reviews in Oral Biology & Medicine

282

266

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“…26,27 It has been claimed that imbalances in levels of free reactive oxygen radicals with antioxidants, play a major role in development of oral diseases and inflammation. 28,29 Given the growing importance of the ROS measurement in saliva, as a help tool in the initial evaluation and follow-up of periodontal disease, and the clinical usefulness of the luminol-dependent chemiluminescence assay, that can quantify minor changes in PMN oxidative metabolism, 30 the levels of ROS were quantified in saliva from patients with AgP and CP and their matched controls. Thus, ROS formation was detected in saliva not only from patients with AgP or CP but in control subjects.…”

Section: Discussionmentioning

confidence: 99%

Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis

et al. 2016

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Objectives: Free radicals play an important role in the onset and progression of many diseases. The aim of this study was to investigate the contribution of oxidative stress in the pathology of aggressive (AgP) and chronic (CP) periodontitis and its relation with the clinical periodontal status. Methods: Eighty subjects were divided into two groups: 20 patients with AgP and 20 patients with CP with their 20 corresponding matched controls, based on clinical attachment loss (CAL), probing pocket depth (PPD), and bleeding on probing (BOP). Saliva reactive oxygen species (ROS), lipid peroxidation, and nonenzymatic antioxidant defences were measured by luminol-dependent chemiluminescence assay, as thiobarbituric acid-reactive substances (TBARs) and total radical-trapping antioxidant potential (TRAP), respectively. Pearson's correlation and multivariate analysis were used to determine the relationship between ROS and TBARs and the clinical parameters. Results: ROS and TBARs were increased in AgP while TRAP was decreased, comparing with CP. In AgP, a strong and positive correlation was observed between ROS and TBARs and they were closely associated with CAL and PPD. Discussion: In AgP, but not in CP, oxidative stress is a high contributor to periodontal pathology and it is closely associated with the clinical periodontal status.

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“…A number of studies have focused on the determination of plasma and tissue levels of CoQ 10 in patients prior to and after treatment [4][5][6][7][8][9][10][11][12][13][14][15]. Several methods have been described for assaying either total CoQ 10 or the reduced and oxidized forms in plasma.…”

Section: Introductionmentioning

confidence: 99%

Analysis of CoQ10 in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration

Pabbisetty

Carvalho

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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Free radical scavenging activity of coenzyme Q measured by a chemiluminescent assay

Cited by 16 publications

References 13 publications

Oxidative Injury and Inflammatory Periodontal Diseases : the Challenge of Anti-Oxidants to Free Radicals and Reactive Oxygen Species

Oxidative Injury and Inflammatory Periodontal Diseases : the Challenge of Anti-Oxidants to Free Radicals and Reactive Oxygen Species

Parameters of oxidative stress in saliva from patients with aggressive and chronic periodontitis

Analysis of CoQ10 in rat serum by ultra-performance liquid chromatography mass spectrometry after oral administration

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