Free Radical Scavenger and Antihepatotoxic Activity ofRosmarinus tomentosus

Abstract

The aerial parts of R. tomentosus were collected during the flowering period (March, 1991) in Velez Benaudalla (Granada, Spain), as populations observed in this area were pure and did not overlap with other species of Rosmarinus. The plant's identity was confirmed by the Department of Botany (Dr. Oswaldo Socorro), Faculty of Pharmacy, University of Granada. The specimens are currently deposited in the GDA (Faculty of Pharmacy, Herbarium, University of Granada) under catalogue number 19471. Total ext ractfor testing The ethanolic extract used for testing was obtained by continuous extraction of 1200 g dried aerial parts from R. tomentosus in a Soxhlet device. This ethanolic extract of R. tomentosus was characterized by thin-layer chromatography: polyphenols (solvent system toluene-ethyl acetate-acetic acid 42 : 30: 9, with FeC1, and UV 320 nm); sterols and triterpenes (solvent system tolueneacetone-acetic acid 100: 3 : 0.7; with Liebermann-Burchard reagent and 110°C). Fractionation of extract Among the different genera of the Lamiaceae family known to have antioxidant and antihepatotoxic properties is the genus Rosmarinus. Unlike the species Rosmarinus officinalis (1-3), which has been the subject of many recent studies, the species Rosmarinus tomentosus is still relatively unknown. This species is found in a completely defined area in the south of the province of Granada (Spain). Both the absence of knowledge about this species, together with its local endemic nature, have led us to begin this study. here, the alcoholic extract and its frac-1.5 x 105M).

Therapeutic Benefits of Garlic against Alloxan-Induced Diabetic in Rats

“…Supporting our finding it has been found by Douaouya et al,(2016)that liver was necrotized in diabetic patients [1] . Therefore, the increment of the activities of AST, ALT, LDH, AlP and AcP in plasma may be mainly due to the leakage of these enzymes from the liver cytosol into the Blood stream, which gives an indication on the hepatotoxic effect of alloxan [42] . On the other hand, treatment of the diabetic rats with garlic caused reduction in the activity of these enzymes in plasma compared to the mean values of diabetic group (Table 2).…”

The effects of aqueous extract of alfalfa on blood glucose and lipids in alloxan-induced diabetic rats

“…When liver enzyme activity increased, it refl ects liver damage in serum. Possibly, increased activity of liver enzymes ALT and AST is because of leakage from the cytosol into the blood stream, leakage increased by liver damage that is caused by diabetes [23]. AST and ALT are good indicators for liver function.…”

Dietary Boron Supplementation and its Impact on Semen Characteristics and Physiological Status of Adult Male Rabbits

“…The transaminases activities in semen are a good indicator of semen quality because they measures sperm membrane stability (Kelso et al, 1997;Zedda et al, 1996). Also, the increments of the activities of AST and ALT in seminal plasma are mainly due to the leakage of these enzymes (Navarro et al, 1993). Yousef and Zeitoun (1998) found that there were negative correlation coefficients between decreased sperm motility on one side and AST and ALT release on the other side.…”