Free Radical Oxidation in Rats in the Delayed Period after Combined Exposure to Dust and Radiation

Тапбергенов, С О; Жетписбаев, Б А; Ilderbayev, Oralbek; Zhetpisbaeva, H. S.; Olzhayeva, R.R.; Prozor, I. I.; Usenova, O.A.; Ilderbayeva, Gulzhan O.

doi:10.1007/s10517-013-2046-z

Cited by 4 publications

(1 citation statement)

References 1 publication

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“…In addition, many people are forced to live in areas where the radiation background has increased as a result of radioactive contamination of the environment after the accident of nuclear power plants, tests, and the use of atomic bombs. The biological reaction of tissues and cells in the human body as a result of ionizing radiation depends on the dose and dose rate [3], [4], [5]. The effect of gamma radiation on non-lethal doses creates a chain of complex processes of cellular reaction, that is, as a result of irradiation of cells and tissues, there is an expression of genes and the breakdown of proteins [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Study of Lipid Peroxidation-antioxidant Defense Systems in Rats under Radiation Exposure

Okassova

Tolegenova

Kuvatbaeva

2022

Open Access Maced J Med Sci

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Abstract BACKGROUND: Experimental data on the effect of a high dose of gamma radiation 6 Gy on the activity of antioxidant defense enzymes and lipid peroxidation products (LPO) are presented immunocompetent organs in the body of animals in the experiment. It was found that the effect of ionizing radiation led to an increase in the level of diene conjugates (DC) and malondialdehyde (MDA), inhibition of the activity of catalase (CАT) and glutathione peroxidase (GlP), glutathione reductase (GlR) enzymes in almost all the studied objects, as a result of which the development of oxidative stress was observed in them. The results of the study indicate serious changes in the lipid peroxidation and antioxidant system (AOS) under radiation stress. An imbalance of POL-AOS creates prerequisites for the occurrence of immunopathological conditions, contributing to the development of radiation-related tumor infection. pathologies. Violations of functional relationships of the catalytic redox system. AIM: The aim of the study was to study the effect of radiation at a dose of 6 Gy on the parameters of lipoperoxidation and the antioxidant system in experimental rats. MATERIAL AND METHODS: The work was carried out on 20 male Wistar rats weighing 240 ± 20 g. Experimental animals are divided into two groups: I - normal group; II - group exposed to γ-rays at a dose of 6 Gy. RESULTS: After radiation exposure, all objects showed a tendency to increase the product of lipid peroxidation. As is known, the activation of lipid peroxidation is based on excessive generation of reactive oxygen species, which exceeds the physiological capabilities of antioxidant systems that occur after the depletion of enzyme systems. CONCLUSION: Based on the results obtained, it was found, that irradiation increases the intensity of the formation of POL products and their accumulation, reduces the activity of enzymes of the antioxidant system in immunocompetent organs in irradiated animals, as a result, the lack of the antioxidant system causes oxidative stress in the body.

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Section: Introductionmentioning

confidence: 99%

Study of Lipid Peroxidation-antioxidant Defense Systems in Rats under Radiation Exposure

Okassova

Tolegenova

Kuvatbaeva

2022

Open Access Maced J Med Sci

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Molecular and immunological changes in blood of rats exposed to various doses of asbestos dust

et al. 2022

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Pharmaceutical care of premedical and first aid in case of injuries: impact of biological and nuclear weapons and radiation exposure from military destruction of nuclear power plants

Tkachenko,

Bulda,

Makarova

et al. 2024

Healthc Low-resour S

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The relevance of the topic is due to the increased risk of radiation hazards on the territory of Ukraine caused by the frequent shelling of nuclear power plants in the Zaporizhzhya region. This research work aims to calculate the percentage of the population that is sufficiently aware of the issues in providing medical care for radiation and other injuries. During the scientific research, the authors used analytical, statistical, and diagnostic methods to study information on radiation hazards and define the specifics and consequences of the use of various types of biological weapons. The main results achieved within the framework of this scientific study would be a clear justification and assessment of the radiation hazards for Ukrainians and a determination of the feasibility and indications for the use of certain medicines. The results obtained and the conclusions formulated on their basis are of practical importance for the military, territorial defence fighters, students of medical universities, sanitary workers, police officers, teachers, drivers, and civilians.

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Free Radical Oxidation in Rats in the Delayed Period after Combined Exposure to Dust and Radiation

Cited by 4 publications

References 1 publication

Study of Lipid Peroxidation-antioxidant Defense Systems in Rats under Radiation Exposure

Study of Lipid Peroxidation-antioxidant Defense Systems in Rats under Radiation Exposure

Molecular and immunological changes in blood of rats exposed to various doses of asbestos dust

Pharmaceutical care of premedical and first aid in case of injuries: impact of biological and nuclear weapons and radiation exposure from military destruction of nuclear power plants

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