Free-operant and T-maze avoidance performance by septal and hippocampal-damaged rats

Duncan, Perry M.; Duncan, Nancy C.

doi:10.1016/0031-9384(71)90132-6

Cited by 64 publications

(19 citation statements)

References 19 publications

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“…The study that is most striking in its discrepancy with the present results is that of Duncan and Duncan (1971), in which septal and hippocampal rats were found to be severely impaired in acquisition of a simultaneous discriminative avoidance task and to perseverate on a spatial hypothesis. The lesions in that experiment were slightly posterior and more lateral than ours, but similar in size.…”

Section: Hypothesis Behavior and Rate Of Acquisitioncontrasting

confidence: 99%

Discriminative avoidance learning in hippocampal and cortical rats: Acquisition rate, behavioral strategies, and long-term retention

Sara

David-Remacle²

1981

Psychobiology

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Facilitation of visually discriminated avoidance learning was observed in rats 1 week after they were lesioned in the dorsal hippocampus. While perseveration of a spatial strategy acquired during a pretraining session occurs in sham-operated and cortically lesioned controls, no such perseveration was observed in hippocampals. Elimination of the presurgical shaping session reduced the number of spatial strategies in all groups, but differences in trials to criterion and percentage of place strategies remained. Retesting the animals 3 weeks after training showed that hippocampals and corticals had poorer retention than did shams. There were no differences in retention of groups tested 24 h after training. The long-term retention deficit seems to be independent of the fact that hippocampals learn faster, since cortically lesioned animals also showed the memory deficit, compared with controls, even though they had as many training trials. The results are taken as a demonstration of lesion-induced anterograde amnesia in the rat.

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Section: Hypothesis Behavior and Rate Of Acquisitioncontrasting

confidence: 99%

Discriminative avoidance learning in hippocampal and cortical rats: Acquisition rate, behavioral strategies, and long-term retention

Sara

David-Remacle²

1981

Psychobiology

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“…Of the remaining studies on non-spatial discrimination, those reporting deficits seem amenable to the interpretation that the hippocampal deficit was a function of either prolonged position hypotheses (e.g. Foshee 1967, Duncan andDuncan 1971) or other stereotyped behaviours interfering with proper discrimination (e.g. Isaacson 1972, Woodruff, Schneiderman, andIsaacson 1972).…”

Section: Discrimination and Maze Learning 281mentioning

confidence: 99%

The Hippocampus as a Cognitive Map

Routtenberg¹,

O’Keefe²,

Nadel³

1980

The American Journal of Psychology

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“…The impact of hippocampal lesions on associative learning that involves motor responding appears to be relatively subtle. A facilitation of acquisition has been reported in both operant (Duncan & Duncan, 1971;Isaacson, Douglas, & Moore, 1961) and classical (Schmaltz & Theios, 1972) paradigms.…”

mentioning

confidence: 95%

Neural and endocrine effects on classical conditioning: A comparison of ACTH and hippocampectomy

et al. 1985

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The effects of bilateral hippocampal lesions and systemic elevation of ACTH were compared using the classically conditioned rabbit nictitating membrane response. Animals with hippocampal lesions and unoperated animals that received ACTH (5I.U. /kg) exhibited a facilitated rate of acquisition and decreased conditioned response onset latency relative to normal control groups or animals with cortical lesions. The administration of ACTH did not alter performance in animals with hippocampal damage, indicating that the effects of these treatments are not additive. The performance of a second group of animals that was treated with a smaller dosage of ACTH (2.5 I.U./kg) was no different from that of any other group, suggesting a dose-dependent effect of the hormone. The selective replication of hippocampal deficits ascribed to a loss of response modulation suggests that ACTH may influence learning by stimulating hippocampal neurons.

show abstract

Free-operant and T-maze avoidance performance by septal and hippocampal-damaged rats

Cited by 64 publications

References 19 publications

Discriminative avoidance learning in hippocampal and cortical rats: Acquisition rate, behavioral strategies, and long-term retention

Discriminative avoidance learning in hippocampal and cortical rats: Acquisition rate, behavioral strategies, and long-term retention

The Hippocampus as a Cognitive Map

Neural and endocrine effects on classical conditioning: A comparison of ACTH and hippocampectomy

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