The stability constants for the Fe(III) complexes of the orally active iron decorporation drug L1 (3-hydroxy-1,2-dimethyl-4-pyridinone) have been determined by potentiometric titration [glass electrode, 25.0 degrees C, mu = 0.15 mol/L (isotonic) NaCl]. A simple computer model of blood plasma (citrate 100 mumol/L, transferrin 37 mumol/L) has been used to compare the Fe(III) binding efficacies in blood of L1 and the clinically used intravenously administered chelating agent deferoxamine.
and thermal parameters, bond distances, and bond angles for both the green and blue forms of [CuL3](BF4)2 (8 pages). Ordering information is given on any current masthead page.
The effects of bilateral hippocampal lesions and systemic elevation of ACTH were compared using the classically conditioned rabbit nictitating membrane response. Animals with hippocampal lesions and unoperated animals that received ACTH (5I.U. /kg) exhibited a facilitated rate of acquisition and decreased conditioned response onset latency relative to normal control groups or animals with cortical lesions. The administration of ACTH did not alter performance in animals with hippocampal damage, indicating that the effects of these treatments are not additive. The performance of a second group of animals that was treated with a smaller dosage of ACTH (2.5 I.U./kg) was no different from that of any other group, suggesting a dose-dependent effect of the hormone. The selective replication of hippocampal deficits ascribed to a loss of response modulation suggests that ACTH may influence learning by stimulating hippocampal neurons.
The water‐soluble iron porphyrin (Fe(III)(TPPS)(H2O)n)3‐ (n = 1 or 2; TPPS: meso‐tetrakis(p‐sulfonatophenyl)porphine) is shown to be an effective electrocatalyst for the reduction of HSO3‐ to H2S (cyclic voltammetric and differential‐pulse polarographic measurements).
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