Fracture simulation of the femoral bone using the finite-element method: How a fracture initiates and proceeds

Ota, T.; Yamamoto, Itsuo; Morita, Rikushi

doi:10.1007/s007740050072

Cited by 80 publications

(57 citation statements)

References 11 publications

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“…In other cases, no information has been provided on the location of the applied force that was used to replicate the experimental forces in the FE models (e.g. Ota et al 1999). Inaccurate identification of such a position would undermine the accuracy of the FE simulation and the comparison between the in vitro experiment and the FE model.…”

Section: (C) Organ Level: Boundary Conditionsmentioning

confidence: 99%

“…For instance, when the hip joint force is applied to the femoral head in vitro (Cristofolini et al 1994(Cristofolini et al , 2007aCody et al 1999;Ota et al 1999;Keyak et al 2005;Taddei et al 2006), it is not possible a priori to determine accurately the position of the resultant force, as: (i) the contact area between the bone surface and the loading device is difficult to measure accurately owing to the large deformation of the bone surface and (ii) even if the contact area was accurately measured, the distribution of the contact pressure (and its resultant) cannot be easily measured experimentally. Additionally, long bones undergo significant deflection when loaded, of the order of some millimetres (Cristofolini & Viceconti 1999a,b;Cristofolini et al 2006).…”

Section: (C) Organ Level: Boundary Conditionsmentioning

confidence: 99%

“…Validation is a crucial aspect since it is the only acknowledged procedure to ensure model reliability for a clinical application (Viceconti et al 2005). After the pioneering work of Huiskes et al (1981), several studies investigated the accuracy with which FE models are able to predict experimentally measured values of surface strains (Lotz et al 1991;Keyak et al 1993;Ota et al 1999;Gupta et al 2004;Anderson et al 2005;Taddei et al 2006Taddei et al , 2007Bessho et al 2007;Schileo et al 2007;Yosibash et al 2007b) and bone-implant micro-motions . Other studies concentrated on the prediction of lumped parameters such as structural stiffness for a given component of loading (Cody et al 2000) or failure load in a given loading configuration (Crawford et al 2003).…”

Section: Introductionmentioning

confidence: 99%

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Mechanical testing of bones: the positive synergy of finite–element models andin vitroexperiments

Cristofolini

Schileo

Juszczyk

et al. 2010

Phil. Trans. R. Soc. A.

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Bone biomechanics have been extensively investigated in the past both with in vitro experiments and numerical models. In most cases either approach is chosen, without exploiting synergies. Both experiments and numerical models suffer from limitations relative to their accuracy and their respective fields of application. In vitro experiments can improve numerical models by: (i) preliminarily identifying the most relevant failure scenarios; (ii) improving the model identification with experimentally measured material properties; (iii) improving the model identification with accurately measured actual boundary conditions; and (iv) providing quantitative validation based on mechanical properties (strain, displacements) directly measured from physical specimens being tested in parallel with the modelling activity. Likewise, numerical models can improve in vitro experiments by: (i) identifying the most relevant loading configurations among a number of motor tasks that cannot be replicated in vitro; (ii) identifying acceptable simplifications for the in vitro simulation; (iii) optimizing the use of transducers to minimize errors and provide measurements at the most relevant locations; and (iv) exploring a variety of different conditions (material properties, interface, etc.) that would require enormous experimental effort. By reporting an example of successful investigation of the femur, we show how a combination of numerical modelling and controlled experiments within the same research team can be designed to create a virtuous circle where models are used to improve experiments, experiments are used to improve models and their combination synergistically provides more detailed and more reliable results than can be achieved with either approach singularly.

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Section: (C) Organ Level: Boundary Conditionsmentioning

confidence: 99%

Section: (C) Organ Level: Boundary Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mechanical testing of bones: the positive synergy of finite–element models andin vitroexperiments

Cristofolini

Schileo

Juszczyk

et al. 2010

Phil. Trans. R. Soc. A.

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“…This approach is currently widely used for prediction of fractures and corresponding loads as well as localization of fracture in femur under different loading conditions; important results in this area are described in [1,2,9,10,13,14]. Assessments of fracture risk and definition of a failure load for bones with metastatic lesions based on the finite-element method were carried out in [3,5,7,15,16].…”

mentioning

confidence: 99%

Formation of microcracks near surgical defect in femur: Assessment of ultimate loading conditions

Босяков¹,

Алексеев²,

Shpileuski³

et al. 2016

ZN PRz Mechanika

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A bone defect of rectangular shape in a femur is considered as a result of a surgical resection of tumor lesions. Based on finite-element calculation of J-integral near the bone defect, ultimate combinations of loads corresponding to formation of microcracks were determined. The loads corresponds to simultaneous actions of own human's weight, flexion-extension, adduction-abduction and rotation of the femur. Recommendations for the prevention of pathological fractures of the femur with the surgical defect based on the obtained results were formulated.

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“…A model of the femur (at the organ level) is first identified by its geometry, which can be obtained, also in vivo, from medical imaging datasets of the region of interest (van Rietbergen et al 1995;Ota et al 1999;Taylor 2003;Keyak et al 2005;Taddei et al 2007). The method of choice for the definition of the bone boundary is segmentation of computed tomography (CT) data, which provide a good contrast between mineralized bone tissue and surrounding soft tissues.…”

Section: Organ Level: the Bone Modelmentioning

confidence: 99%

Multiscale investigation of the functional properties of the human femur

Cristofolini

Taddei

Baleani

et al. 2008

Phil. Trans. R. Soc. A.

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The mechanical strength of human bones has often been investigated in the past. Bone failure is related to musculoskeletal loading, tissue properties, bone metabolism, etc. This is intrinsically a multiscale problem. However, organ-level performance in most cases is investigated as a separate problem, incorporating only part (if any) of the information available at a higher scale (body level) or at a lower one (tissue level, cell level). A multiscale approach is proposed, where models available at different levels are integrated. A middle-out strategy is taken: the main model to be investigated is at the organ level. The organ-level model incorporates as an input the outputs from the bodylevel (musculoskeletal loads), tissue-level (constitutive equations) and cell-level models (bone remodelling). In this paper, this approach is exemplified by a clinically relevant application: fractures of the proximal femur. We report how a finite-element model of the femur (organ level) becomes part of a multiscale model. A significant effort is related to model validation: a number of experiments were designed to quantify the model's sensitivity and accuracy. When possible, the clinical accuracy and the clinical impact of a model should be assessed. Whereas a large amount of information is available at all scales, only organ-level models are really mature in this perspective. More work is needed in the future to integrate all levels fully, while following a sound scientific method to assess the relevance and validity of such an integrated model.

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Fracture simulation of the femoral bone using the finite-element method: How a fracture initiates and proceeds

Cited by 80 publications

References 11 publications

Mechanical testing of bones: the positive synergy of finite–element models andin vitroexperiments

Mechanical testing of bones: the positive synergy of finite–element models andin vitroexperiments

Formation of microcracks near surgical defect in femur: Assessment of ultimate loading conditions

Multiscale investigation of the functional properties of the human femur

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