Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost

Zhou, Ruyi; Yan, Liang; Dong, Xinghua; Zhu, Shuang; Chen, Kui; Wu, Yanrui; Xiang, Huandong; Li, Lele; Zhang, Guangjin; Gu, Zhennan; Zhao, Ye

doi:10.1016/j.nantod.2020.101003

Cited by 28 publications

(20 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination of immunotherapy and RT can overcome some of the limitations associated with individual therapy. [95][96][97] For example, immunotherapy for many tumors is performed using a single reagent that is specific to tumor subtype/antigen. The heterogeneity of the tumor results in poor therapeutic efficacy and may lead to resistance and recurrence.…”

Section: Immuno-radiotherapymentioning

confidence: 99%

Multifunctional high-Z nanoradiosensitizers for multimodal synergistic cancer therapy

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Immuno-radiotherapymentioning

confidence: 99%

Multifunctional high-Z nanoradiosensitizers for multimodal synergistic cancer therapy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The immune checkpoint inhibitor anti‐PD‐L1 was also introduced into the system to regulate the tumor immune escape. As a result, the ultrasmall nanoclusters realized an efficient immunoradiotherapy [62] …”

Section: Multimodal Imaging‐guided Combined Therapymentioning

confidence: 99%

“… Schematic illustration of the fabrication of Fe 4 Se 2 W 18 nanoclusters (NCs) and the mechanism of Fe 4 Se 2 W 18 NCs‐mediated immunoradiotherapy with a fractionated dose regimen for tumor‐specific radiosensitization augment and antitumor immunity boost [62] . Copyright 2020, Elsevier Ltd.…”

Section: Multimodal Imaging‐guided Combined Therapymentioning

confidence: 99%

Polyoxometalate‐Based Nanomaterials Toward Efficient Cancer Diagnosis and Therapy

Lü

Wang

et al. 2021

Chemistry A European J

View full text Add to dashboard Cite

As an emerging class of inorganic metal oxides, organically functionalized polyoxometalates (POMs) or POM‐based nanohybrids have been demonstrated promising potential for the inhibition of various cancer types by the virtue of their diversity in structures and significantly reduced toxicity. This contribution summarizes the latest achievement of POM‐based nanomaterials in cancer diagnosis and various therapeutics to put forward our fundamental viewpoints on the design principles of modified POMs based on their application. In addition, major challenges and perspectives in this field are also discussed. We expect that this review will provide a valuable and systematic reference for the further development of POM‐based nanomaterials.

show abstract

“…Gold clusters possess activities like SOD, CAT and GPx enzymes, performing significant antioxidant effects in TBI treatment [26,[28][29][30][31]. Though nanotechnologies for TBI diagnosis and monitoring were employed to promote the activity and utilization of nanozymatic biocatalysts like atom engineering, surface modification, and size modulation [32][33][34], it remains painless and chanllenged for clinical translation [12,15,[29][30][31][35][36][37][38][39][40][41][42][43][44][45]. Different from the intravenous injection, the noninvasive diagnosis and stimulation for TBI can achieve rapid and painless treatment, worthy of considering to promote recovery and minimize disability.…”

Section: Introductionmentioning

confidence: 99%

Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma

et al. 2021

View full text Add to dashboard Cite

Background Neurotrauma is a worldwide public health problem which can be divided into primary and secondary damge. The primary damge is caused by external forces and triggers the overproduction of peroxides and superoxides, leading to long-lasting secondary damage including oxidative stress, wound infection and immunological reactions. The emerging catalysts have shown great potential in the treatment of brain injury and neurogenic inflammation, but are limited to biosafety issues and delivery efficiency. Results Herein, we proposed the noninvasive delivery route to brain trauma by employing highly active gold clusters with enzyme-like activity to achieve the early intervention. The decomposition rate to H2O2 of the ultrasmall gold clusters is 10 times that of glassy carbon (GC) electrodes, indicating excellent catalytic activity. The gold clusters can relieve the oxidative stress and decrease the excessive O2·− and H2O2 both in vitro and in vivo. Besides, gold clusters can accelerate the wound healing of brain trauma and alleviate inflammation via inhibiting the activation of astrocytes and microglia through noninvasive adminstration. decrease the peroxide and superoxide of brain tissue. Conclusions Present work shows noninvasive treatment is a promising route for early intervention of brain trauma.

show abstract

Fractionated regimen-suitable immunoradiotherapy sensitizer based on ultrasmall Fe4Se2W18 nanoclusters enable tumor-specific radiosensitization augment and antitumor immunity boost

Cited by 28 publications

References 63 publications

Multifunctional high-Z nanoradiosensitizers for multimodal synergistic cancer therapy

Multifunctional high-Z nanoradiosensitizers for multimodal synergistic cancer therapy

Polyoxometalate‐Based Nanomaterials Toward Efficient Cancer Diagnosis and Therapy

Catalytically active gold clusters with atomic precision for noninvasive early intervention of neurotrauma

Contact Info

Product

Resources

About