Multifunctional high-Z nanoradiosensitizers for multimodal synergistic cancer therapy

Abstract

Radiotherapy (RT) is one of the most common and effective clinical therapies for malignant tumors. However, there are several limitations that undermine the clinical efficacy of cancer RT, including low...

Advances and applications of nanoparticles in cancer therapy

“…[757][758][759][760] NPs, with their unique properties, can overcome some of the drawbacks associated with conventional chemotherapeutic drug delivery, cap tumor hypoxia, and augment radiosensitization, thus boosting the antitumor effectiveness of chemo-RT. [761][762][763][764] Conventional chemotherapeutic agents such as cisplatin, taxanes, and 5-fluorouracil serves as radiosensitizers enhancing the antitumor ability of RT. However, the concentration, metabolism ratio, and tumor retention of these drugs are usually uncontrollable, leading to various systemic toxicities.…”

“…However, several challenges limit the full potential of chemo‐RT, including the toxicities induced by traditional systemic medication of chemotherapeutic agents, tumor hypoxia‐related radioresistance, and injury to surrounding normal tissues caused by high radiation doses 757–760 . NPs, with their unique properties, can overcome some of the drawbacks associated with conventional chemotherapeutic drug delivery, cap tumor hypoxia, and augment radiosensitization, thus boosting the antitumor effectiveness of chemo‐RT 761–764 …”

Oxygen-generating biocatalytic nanomaterials for tumor hypoxia relief in cancer radiotherapy

“…In addition to the abovementioned CAT-like BCNs, many other high-Z based oxygengenerating BCNs have also been explored to enhance the radiosensitivity of tumors. 58,[78][79][80][81] These high-Z nanomaterials can deposit large amounts of radiation energy within tumors. To improve the efficacy of RT, there is a great need to explore some novel nanomaterials that can act as both hypoxia antagonists and radiosensitizers.…”

Enhanced mechanical and tribological properties of epoxy‐based coatings by in‐situ synthesized silicon dioxide nanoparticles

“…Recently, many studies have focused on improving the mechanical properties of polymer by introducing inorganic nano‐particles. The nano‐fillers can provide epoxy coatings with higher hardness, stiffness and wear resistance, such as SiO 2, 19 flake aluminum, 20 titanium dioxide (TiO 2 ), 21 h‐BN, 22 and so on. In addition, the addition of inorganic fillers could overcome the inherent weaknesses of polymer materials, and reduce the crack propagation of the coating 23 .…”