Polyoxometalate‐Based Nanomaterials Toward Efficient Cancer Diagnosis and Therapy

Lü, Fei; Wang, Mengzhen; Li, Na; Tang, Bo

doi:10.1002/chem.202004500

Cited by 30 publications

(19 citation statements)

References 116 publications

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“…Over recent decades, POMs have attracted more and more attention due to their good redox activities and outstanding electron and proton transport capacities [19], and it has been proven that they can inhibit the development of cancer [8]; polyoxometalates have been widely used as antitumor drugs in medicine [20,21].…”

Section: Discussionmentioning

confidence: 99%

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K5BW12O40 Induces the Apoptosis of A549 Cells by Regulating Caspase-3

Liu

et al. 2022

Journal of Chemistry

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Objective. The purpose of the study is to explore the effect of K5BW12O40, a polyoxometalate (POM), on the apoptosis of A549 cells and its underlying mechanism and to analyze the potential therapeutic effect of K5BW12O40 in non-small-cell lung cancer. Materials and Methods. A549 cells were treated with different concentrations of K5BW12O40 (0 mg/ml, 0.001 mg/ml, 0.01 mg/ml, and 0.1 mg/ml). The proliferation of A549 cells treated with different concentrations of K5BW12O40 was detected by MTT assay (3-(4,5-dimethylthiazol-2-yl)-2 and 5-diphenyl tetrazolium bromide). The apoptosis of A549 cells induced by K5BW12O40 was detected by flow cytometry. Western blot was used to detect the changes in Bax and caspase-3 protein levels in A549 cells induced by K5BW12O40. Results. As the dose of the K5BW12O40 increases, the cell viability of A549 cells gradually decreases. The results of flow cytometry showed that the apoptotic rate of A549 cells increased with the increase of K5BW12O40 concentration. Western blot results showed that the expression of the apoptosis marker protein caspase-3 was increased in the three groups treated with K5BW12O40 whereas the protein level of Bax did not change significantly in A549 cells treated with K5BW12O40. Conclusions. K5BW12O40 increases the apoptotic rate of A549 cells by upregulating caspase-3.

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Section: Discussionmentioning

confidence: 99%

“…ere have been many reports that con rmed that polyoxometalates (POMs) can inhibit the growth of tumor cells due to their structural diversity and signi cantly reduced toxicity [8]. [9] Polyoxometalates have adjustable structural charge and size and possess the potential to produce organic-inorganic hybrids [10].…”

Section: Introductionmentioning

confidence: 99%

K5BW12O40 Induces the Apoptosis of A549 Cells by Regulating Caspase-3

Liu

et al. 2022

Journal of Chemistry

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“…The antibacterial properties and antitumor activity of the heteropolytungstates in aquaeous solution have also been reported by Ma et al [ 22 ]. The anticancer properties of POMs were reported by Shin et al, Bijelic et al, Li et al, Hu et al, and Lu et al [ 23 , 24 , 25 , 26 , 27 , 28 ]. Chaudhary et al used polyoxo compounds as nano-inhibitors of amyloid aggregation [ 29 ].…”

Section: Introductionmentioning

confidence: 94%

New Organic-Inorganic Hybrid Compounds Based on Sodium Peroxidomolybdates (VI) and Derivatives of Pyridine Acids: Structure Determination and Catalytic Properties

et al. 2022

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Two organic-inorganic hybrids based on sodium peroxidomolybdates(VI) and 3,5-dicarboxylic pyridine acid (Na-35dcpa) or N-oxide isonicotinic acid (Na-isoO) have been synthesized and characterized. All compounds contain inorganic parts: a pentagonal bipyramid with molybdenum center, and an organic part containing 3,5-dicarboxylic pyridine acid or N-oxide isonicotinic acid moieties. The type of organic part used in the synthesis influences the crystal structure of obtained compounds. This aspect can be interesting for crystal engineering. Crystal structures were determined using powder X-ray diffraction or single crystal diffraction for compounds Na-35dcpa and Na-isoO, respectively. Elemental analysis was used to check the purity of the obtained compounds, while X-ray Powder Diffraction (XRPD) vs. temp. was applied to verify their stability. Moreover, all the compounds were examined by Infrared (IR) spectroscopy. Their catalytic activity was tested in the Baeyer–Villiger (BV) oxidation of cyclohexanone to ε-caprolactone in the oxygen-aldehyde system. The highest catalytic activity in the BV oxidation was observed for Na-35dcpa. The compounds were also tested for biological activity on human normal cells (fibroblasts) and colon cancer cell lines (HT-29, LoVo, SW 620, HCT 116). All compounds were cytotoxic against tumor cells with metastatic characteristics, which makes them interesting and promising candidates for further investigations of specific anticancer mechanisms.

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“…POMs are polynuclear metal oxide anions that are molecular analogues of solid-state metal oxides. Diverse fields such as, water oxidation catalysts ( Blasco-Ahicart et al, 2018 ), photocatalysis ( Costa-Coquelard et al, 2010 ), molecular electronics ( Busche et al, 2014 ), quantum computation ( Gaita-Ariño et al, 2019 ), biology ( Gumerova and Rompel, 2021 ) and medicinal science ( Lu et al, 2021 ) have all been impacted by POM chemistry. Current findings demonstrate the feasibility of hydrogen-production using silicotungstic acid, H 6 [SiW 12 O 4 ], by coupling low-pressure oxygen production via water oxidation linked to non-electrolyzer catalytic hydrogen production ( Rausch et al, 2014 ).…”

Section: Molecular Metal Oxides or Polyoxometalatesmentioning

confidence: 99%

Looking for Options to Sustainably Fixate Nitrogen. Are Molecular Metal Oxides Catalysts a Viable Avenue?

2021

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Fast and reliable industrial production of ammonia (NH3) is fundamentally sustaining modern society. Since the early 20th Century, NH3 has been synthesized via the Haber–Bosch process, running at conditions of around 350–500°C and 100–200 times atmospheric pressure (15–20 MPa). Industrial ammonia production is currently the most energy-demanding chemical process worldwide and contributes up to 3% to the global carbon dioxide emissions. Therefore, the development of more energy-efficient pathways for ammonia production is an attractive proposition. Over the past 20 years, scientists have imagined the possibility of developing a milder synthesis of ammonia by mimicking the nitrogenase enzyme, which fixes nitrogen from the air at ambient temperatures and pressures to feed leguminous plants. To do this, we propose the use of highly reconfigurable molecular metal oxides or polyoxometalates (POMs). Our proposal is an informed design of the polyoxometalate after exploring the catabolic pathways that cyanobacteria use to fix N2 in nature, which are a different route than the one followed by the Haber–Bosch process. Meanwhile, the industrial process is a “brute force” system towards breaking the triple bond N-N, needing high pressure and high temperature to increase the rate of reaction, nature first links the protons to the N2 to later easier breaking of the triple bond at environmental temperature and pressure. Computational chemistry data on the stability of different polyoxometalates will guide us to decide the best design for a catalyst. Testing different functionalized molecular metal oxides as ammonia catalysts laboratory conditions will allow for a sustainable reactor design of small-scale production.

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Polyoxometalate‐Based Nanomaterials Toward Efficient Cancer Diagnosis and Therapy

Cited by 30 publications

References 116 publications

K5BW12O40 Induces the Apoptosis of A549 Cells by Regulating Caspase-3

K5BW12O40 Induces the Apoptosis of A549 Cells by Regulating Caspase-3

New Organic-Inorganic Hybrid Compounds Based on Sodium Peroxidomolybdates (VI) and Derivatives of Pyridine Acids: Structure Determination and Catalytic Properties

Looking for Options to Sustainably Fixate Nitrogen. Are Molecular Metal Oxides Catalysts a Viable Avenue?

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