Fractionated extraction of saponins from Brazilian ginseng by sequential process using supercritical CO2, ethanol and water

Bitencourt, Raphaela Gabrí; Queiroga, Carmen Lucia; Montanari, Ílio; Cabral, Fernando A.

doi:10.1016/j.supflu.2014.06.009

Cited by 39 publications

(18 citation statements)

References 45 publications

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“…Some patents also revealed that the propolis extracts obtained by SFE with CO 2 and ethanol improved the extraction efficiency of active compounds from this matrix, including, for example, the Artepillin C and p-coumaric acid [ 92 – 93 ]. Similar results to this study were identified by Garmus et al [ 94 ], Porto et al [ 95 ], Bitencourt et al [ 96 ] and Campos et al [ 97 ], when evaluated different concentrations of the co-solvent in the extraction process.…”

Section: Resultssupporting

confidence: 91%

Determination of Parameters for the Supercritical Extraction of Antioxidant Compounds from Green Propolis Using Carbon Dioxide and Ethanol as Co-Solvent

et al. 2015

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The aim of this study was to determine the best processing conditions to extract Brazilian green propolis using a supercritical extraction technology. For this purpose, the influence of different parameters was evaluated such as S/F (solvent mass in relation to solute mass), percentage of co-solvent (1 and 2% ethanol), temperature (40 and 50°C) and pressure (250, 350 and 400 bar) using supercritical carbon dioxide. The Global Yield Isotherms (GYIs) were obtained through the evaluation of the yield, and the chemical composition of the extracts was also obtained in relation to the total phenolic compounds, flavonoids, antioxidant activity and 3,5-diprenyl-4-hydroxicinnamic acid (Artepillin C) and acid 4-hydroxycinnamic (p-coumaric acid). The best results were identified at 50°C, 350 bar, 1% ethanol (co-solvent) and S/F of 110. These conditions, a content of 8.93±0.01 and 0.40±0.05 g/100 g of Artepillin C and p-coumaric acid, respectively, were identified indicating the efficiency of the extraction process. Despite of low yield of the process, the extracts obtained had high contents of relevant compounds, proving the viability of the process to obtain green propolis extracts with important biological applications due to the extracts composition.

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Section: Resultssupporting

confidence: 91%

Determination of Parameters for the Supercritical Extraction of Antioxidant Compounds from Green Propolis Using Carbon Dioxide and Ethanol as Co-Solvent

et al. 2015

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“…These methods can led to an increase in the process efficiency. However, it should be considered that under harsher conditions (higher temperature and pressure), saponins can be hydrolyzed and degraded, so rather mild processes should be used [45][46][47][48][49].…”

Section: Application and Characterization Of Surfactantsmentioning

confidence: 99%

Saponin-Based, Biological-Active Surfactants from Plants

Kręgiel¹,

Berłowska²,

Witońska³

et al. 2017

Application and Characterization of Surfactants

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106

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Plants have the ability to synthesize almost unlimited number of substances. In many cases, these chemicals serve in plant defense mechanisms against microorganisms, insects, and herbivores. Generally, any part of the plant may contain the various active ingredients. Among the plant, active compounds are saponins, which are traditionally used as natural detergents. The name 'saponin' comes from the Latin word 'sapo,' which means 'soap' as saponins show the unique properties of foaming and emulsifying agents. Steroidal and triterpenoid saponins can be used in many industrial applications, from the preparation of steroid hormones in the pharmaceutical industry to utilization as food additives that exploit their non-ionic surfactant properties. Saponins also exhibit different biological activities. This chapter has been prepared by participants of the Marie Sklodowska-Curie Action-Research and Innovation Staff Exchange (RISE) in the framework of the proposal 'ECOSAPONIN.' Interactions between the participants, including chemists, physicists, technologists, microbiologists and botanists from four countries, will contribute to the development of collaborative ties and further promote research and development in the area of saponins in Europe and China. Although this chapter cannot provide a comprehensive account of the state of knowledge regarding plant saponins, we hope that it will help make saponins the focus of ongoing international cooperation.

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“…Traditional methods, including maceration extraction (ME) [22] and Soxhlet and reflux extraction (SE and RE) [23], and nontraditional techniques, supercritical fluid extraction (SCFE), and ultrasonic-assisted extraction (UAE) [24], are generally used for saponins extraction. Nonetheless, some disadvantages are associated with these methods (e.g., long-time consumption, tedious extraction processes, massive organic solvent usage, high energy input, low yield, high apparatus requirements, complex operations, and environmental issues) [25].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

Deng

Liu

Zou

2019

Journal of Chemistry

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A microwave-assisted extraction (MAE) method was applied to separate saponins from Sapindus mukorossi pericarps. The most important factors of the six extraction parameters were selected using Plackett–Burman designs; therefore, the further extraction procedure was optimized using the Box–Behnken designs; meanwhile, the optimum processing parameters and well-pleasing saponins extraction rate were inferred. The final operation conditions were the ethanol concentration of 40%, soaking time of 3 h, particle size of 80–100 meshes, extraction time of 13 min, solvent-solid ratio of 19 mL/g, and microwave power of 425 W. Based on the optimal extraction parameters, the extraction rate of the saponins by means of MAE technique reached 280.55 ± 6.81 mg/g, which exceeds yields acquired using conventional manners. Saponins from S. mukorossi have obvious xanthine oxidase inhibitory properties in vitro compared with allopurinol. The saponins displayed a type of competitive inhibition of xanthine oxidase. In conclusion, a MAE technique in association with a response surface design provides an efficient extraction tactics, which could sufficiently isolate saponins from S. mukorossi pericarps; further, this technique could be applied to the dissociation of other bioactive substances from plant sources. In addition, the saponins may be a promising alternative to conventional medicine to treat gout and other inflammation-associated disorders to mitigate the side effects of traditional drugs.

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Fractionated extraction of saponins from Brazilian ginseng by sequential process using supercritical CO2, ethanol and water

Cited by 39 publications

References 45 publications

Determination of Parameters for the Supercritical Extraction of Antioxidant Compounds from Green Propolis Using Carbon Dioxide and Ethanol as Co-Solvent

Determination of Parameters for the Supercritical Extraction of Antioxidant Compounds from Green Propolis Using Carbon Dioxide and Ethanol as Co-Solvent

Saponin-Based, Biological-Active Surfactants from Plants

Optimization of Microwave-Assisted Extraction Saponins from Sapindus mukorossi Pericarps and an Evaluation of Their Inhibitory Activity on Xanthine Oxidase

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