FOXP3 and SQSTM1/P62 correlate with prognosis and immune infiltration in hepatocellular carcinoma

Liu, Shuohui; Zhang, Honglong; Yan, Jun; Bai, Zhongtian; Li, Xun

doi:10.1016/j.prp.2022.154292

Cited by 4 publications

(2 citation statements)

References 56 publications

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Section: Mechanisms Of Foxp3 and Foxp3+ Treg Cell Pro-cancer In Malig...mentioning

confidence: 99%

“…Foxp3 expression is down-regulated in HCC tissues, but P62 expression is up-regulated. Low Foxp3 expression and P62 over-expression are found to be closely connected to a decrease in overall survival in HCC patients (94). Liu et al (95) has discovered that the Foxp3 promoter and CpG region are hypermethylated by NA (cytosine-5)-methyl transferase 1 (DNMT1), which can limit Foxp3+Treg function and negatively controls HCC progression.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

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Advances in Foxp3+ regulatory T cells (Foxp3+ Treg) and key factors in digestive malignancies

Wang,

Ding,

Wang

et al. 2024

Front. Immunol.

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Foxp3+ regulatory T cells (Foxp3+ Treg) play a role in regulating various types of tumors, but uncertainty still exists regarding the exact mechanism underlying Foxp3+ Treg activation in gastrointestinal malignancies. As of now, research has shown that Foxp3+ Treg expression, altered glucose metabolism, or a hypoxic tumor microenvironment all affect Foxp3+ Treg function in the bodies of tumor patients. Furthermore, it has been demonstrated that post-translational modifications are essential for mature Foxp3 to function properly. Additionally, a considerable number of non-coding RNAs (ncRNAs) have been implicated in the activation of the Foxp3 signaling pathway. These mechanisms regulating Foxp3 may one day serve as potential therapeutic targets for gastrointestinal malignancies. This review primarily focuses on the properties and capabilities of Foxp3 and Foxp3+Treg. It emphasizes the advancement of research on the regulatory mechanisms of Foxp3 in different malignant tumors of the digestive system, providing new insights for the exploration of anticancer treatments.

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Section: Mechanisms Of Foxp3 and Foxp3+ Treg Cell Pro-cancer In Malig...mentioning

confidence: 99%

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Advances in Foxp3+ regulatory T cells (Foxp3+ Treg) and key factors in digestive malignancies

Wang,

Ding,

Wang

et al. 2024

Front. Immunol.

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Regulatory T cells inhibit FoxP3 to increase the population of tumor initiating cells in hepatocellular carcinoma

Liu,

Tu,

Cai

et al. 2024

J Cancer Res Clin Oncol

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Purpose Tumor initiating cells (TICs) or cancer stem cells (CSCs) are considered to be the main culprit of hepatocellular carcinoma (HCC) initiation and progression, nevertheless the mechanism by which tumor microenvironment maintains the HCC ‘stemness’ is not fully understood. This study aims to investigate the effect of regulatory T cells (Tregs) on the TICs characteristics of HCC. Methods Immunocytochemistry, flow cytometry, real-time PCR, western blot, in vitro sphere-formation, and in vivo tumorigenesis assay were used to detect HCC ‘stemness’. Additionally, after forced expression or inhibition of FoxP3, β-catenin expression and HCC ‘stemness’ were investigated. Results Tregs enhanced the ‘stemness’ of HCC cells by upregulating TIC-related markers CD133, Oct3/4, Sox2, c-Myc, Klf4, Nanog, CD13, EpCAM, and inducting epithelial to mesenchymal transition (EMT), increasing TICs ratio, as well as promoting tumorigenic ability. Moreover, β-catenin and c-Myc were upregulated in HCC cells after co-cultured with Tregs. HCC ‘stemness’ was inhibited after treatment with Wnt/β-catenin pathway inhibitor. Furthermore, forced expression of FoxP3 resulted in increased GSK3β, decreased β-catenin and TIC ratio in HCC. In contrast, FoxP3 interference reduced GSK3β, enhanced β-catenin and TIC ratio of HCC. Conclusion This study, for the first time, demonstrated that Tregs increased the population of TICs in HCC by inhibiting FoxP3 as well as promoting β-catenin expression.

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Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway

Wong,

Aziz,

Ch’ng

et al. 2024

J Mol Histol

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FOXP3 and SQSTM1/P62 correlate with prognosis and immune infiltration in hepatocellular carcinoma

Cited by 4 publications

References 56 publications

Advances in Foxp3+ regulatory T cells (Foxp3+ Treg) and key factors in digestive malignancies

Advances in Foxp3+ regulatory T cells (Foxp3+ Treg) and key factors in digestive malignancies

Regulatory T cells inhibit FoxP3 to increase the population of tumor initiating cells in hepatocellular carcinoma

Expression of LC3A, LC3B and p62/SQSTM1 autophagy proteins in hepatocellular carcinoma (HCC) tissues and the predicted microRNAs involved in the autophagy-related pathway

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