Regulatory T cells inhibit FoxP3 to increase the population of tumor initiating cells in hepatocellular carcinoma
Chang Liu,
Yi-jun Tu,
Hong-Yang Cai
et al.
Abstract:Purpose
Tumor initiating cells (TICs) or cancer stem cells (CSCs) are considered to be the main culprit of hepatocellular carcinoma (HCC) initiation and progression, nevertheless the mechanism by which tumor microenvironment maintains the HCC ‘stemness’ is not fully understood. This study aims to investigate the effect of regulatory T cells (Tregs) on the TICs characteristics of HCC.
Methods
Immunocytochemistry, flow cytometry, real-time PCR, weste… Show more
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