Advances in Foxp3+ regulatory T cells (Foxp3+ Treg) and key factors in digestive malignancies
Wanyao Wang,
Minglu Ding,
Qiuhong Wang
et al.
Abstract:Foxp3+ regulatory T cells (Foxp3+ Treg) play a role in regulating various types of tumors, but uncertainty still exists regarding the exact mechanism underlying Foxp3+ Treg activation in gastrointestinal malignancies. As of now, research has shown that Foxp3+ Treg expression, altered glucose metabolism, or a hypoxic tumor microenvironment all affect Foxp3+ Treg function in the bodies of tumor patients. Furthermore, it has been demonstrated that post-translational modifications are essential for mature Foxp3 to… Show more
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